Successful treatment of mycoplasmosis in layer chickens with single dose therapy

Arzey, G G; Arzey, K E

doi:10.1111/j.1751-0813.1992.tb07478.x

Cited by 11 publications

(10 citation statements)

References 17 publications

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“…The details result of Tylosin and Tiamulin was shown in Table 1. The study is in agreement with Arzey and Arzey, (1992), who evaluated efficacy of Tiamulin, Tylosin, Spiramycin oxytetracyline and dihydrostreptomycin at different dosages to layer hens naturally infected with Mycoplasma gallisepticum. The cure rate was significantly higher (P less than 0.05) in treated hens than in untreated hens, as early as 1 day after treatment.…”

Section: Resultssupporting

confidence: 88%

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Habib

Mahdy

Islam

et al. 2017

Res. Agric. Livest. Fish.

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Tylosin Tiamulin Mycoplasmosis Layer CRD Chronic respiratory disease (CRD) is one of the most important veterinary diseases inBangladesh and all over the world. Mortality, reducing of weight gain and increasing of feed conversion ratio (FCR) are caused by CRD. Several drugs are used for prevention and control of Mycoplasmosis. It is caused by Mycoplasma gallisepticum (MG). Tylosin and Tiamulin are effective on M. gallisepticum. By considering generating resistance against antibiotics that is effective on MG, studying the effect of these drugs in the treatment and prevention of Mycoplasmosis in birds were the purpose of this research. In this study, 36 layer birds (MG positive) of 25 weeks aged divided in three similar groups (A, B and C) contain 12 birds in each group. In group A; Tylosin was administered after mixing with 2.5 gm in 1 L drinking water, for Group B; Tiamulin was administered after mixing with feed @ 0.45gm/kg feed and Group C; Control (No antibiotic was given, only common feeding). The Serum Plate Agglutination (SPA) test was conducted; in positive cases granules were formed slowly which could be seen during rocking. In the negative case, no such granules were formed. Overall 6 and 9 serums shown negative SPA test in Group A and Group B, respectively. Therefore, the efficacy of Tylosin was 50.00% and the Tiamulin was 75.00% which resemble statistically significant (P<0.05). In control group, 5 birds were died during experiment. It can be concluded that usage of these antibiotics especially Tiamulin can be essential in the treatment and prevention of Mycoplasmosis in birds.

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Section: Resultssupporting

confidence: 88%

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Habib

Mahdy

Islam

et al. 2017

Res. Agric. Livest. Fish.

View full text Add to dashboard Cite

show abstract

“…The study is in agreement with who evaluated efficacy of Tiamulin, Tylosin, Spiramycin, oxytetracyline and dihydrostreptomycin at different dosages to layer hens naturally infected with Mycoplasma gallisepticum. 26 The cure rate was significantly higher in treated hens than in untreated hens, as early as one day after treatment.…”

Section: D-tylo50/25mentioning

confidence: 86%

Pharmacokinetics, tissue residues and efficacy of D-Tylo50/25® (tylosin-doxycycline combination) in broiler chickens

Aboubakr

Elbadawy

2017

Int J Basic Clin Pharmacol

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Background: Pharmacokinetic study of a commercial tylosin-doxycycline combination product (D-Tylo50/25®) was conducted in broiler chickens following intravenous (IV) and oral (PO) administration at doses of 50 mg/kgb. wt. (tylosin) and 25 mg/kg b. wt. (doxycycline).Methods: Serum drug concentrations were determined by a validated high performance liquid chromatography (HPLC) using UV detection.Results: A rapid and nearly complete absorption of both drugs with a mean PO bioavailability of 89.16% (tylosin) and 94.30% (doxycycline), prolonged elimination half-lives, and high tissue penetration with steady state volume of distribution of 6.73L/kg (tylosin) and 5.51L/kg (doxycycline) were observed. Tissue residues were studied following oral administration of each drug alone for fiveconsecutive days and blood and tissue samples were obtained for 10 days after the last dose. Residues of tylosin and doxycyclines showed that kidney, liver and lung contained highest drug residues and completely disappeared from those tissues at 5 and 6 days after the last oral dose, respectively. The efficacies of D-Tylo50/25® and other antibiotics (tiamulin and oxytetracyline) were investigated in broiler chicks experimentally infected by Mycoplasma gallisepticum.Conclusions: The pharmacokinetics of both drugs was characterized by a rapid and complete absorption, extensive tissue distribution and slow elimination. D-Tylo50/25® is more effective than tiamulin and oxytetracycline against Mycoplasma gallisepticum infection in broilers.

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“…Poultry industry, a rapidly growing food producing industry, requires efficacious and safe antibiotics that provide high efficacy and leaves minimal residues for treating diseases including chronic respiratory disease (caused by Mycoplasma gallisepticum ). The causative organism, M. gallisepticum, is highly sensitive to quinolones, tetracyclines, macrolides, and tiamulin (Arzey & Arzey, ; Yang et al ; Yang, Sun, Zhao, Wang, & Wang, ). Tiamulin, a pleuromutilin derivative, is an ideal anti‐mycoplasmal drug, due to its distinct advantages such as relatively high cure rate, very low “minimum inhibitory concentration” (MIC), least resistance development, and shorter withdrawal period (Islam, Klein, & Burch, ; Xia et al, ), and its use is approved in India.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and relative bioavailability of tiamulin in broiler chicken as influenced by different routes of administration

Prabhakaran¹,

Srinivasan²,

Nair³

et al. 2019

Vet Pharm & Therapeutics

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The bioavailability and pharmacokinetic disposition of tiamulin in broiler chicken were investigated after administration through the crop, drinking water, and feed at 40 mg/kg body weight. Residues of tiamulin in tissues of broiler chicken were also assessed. Plasma and tissue concentrations of tiamulin were analyzed by reverse‐phase high‐performance liquid chromatography (HPLC) method. Plasma concentration–time data were described by the non‐compartmental model for all three routes, and pharmacokinetic parameters were calculated. There were no significant differences (p > 0.05) in pharmacokinetic parameters and mean plasma concentrations of tiamulin between three routes tested (crop, water, and feed), indicating equal efficacy. Tiamulin residues in edible tissues (muscles, skin, and fat) were lower than the advocated maximum residue limit (MRL of 0.1 µg/g and that of liver was 1 µg/g) on the 3rd day. No traces were found on the 5th day after drug administration. This indicated that the withdrawal period (less than 5 days) is very short, which makes it safer. This study shows that tiamulin can be used with equal efficacy through all routes of administration in broiler chicken (crop, water, and feed).

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Successful treatment of mycoplasmosis in layer chickens with single dose therapy

Cited by 11 publications

References 17 publications

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Pharmacokinetics, tissue residues and efficacy of D-Tylo50/25® (tylosin-doxycycline combination) in broiler chickens

Pharmacokinetics and relative bioavailability of tiamulin in broiler chicken as influenced by different routes of administration

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