Successful Treatment of Nocardia nova Bacteremia and Multilobar Pneumonia With Clarithromycin in a Heart Transplant Patient

Naik, Sarjita D; Mateo-Bibeau, R; Shinnar, Meir; Mahal, Monzarin; Freudenberger, Ronald S

doi:10.1016/j.transproceed.2006.11.029

Cited by 10 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clarithromycin can be an alternative treatment in cases of sulfonamide resistance, intolerance, or allergy. 10 Our patient was initiated on treatment with co-trimoxazole, but in view of dissemination while on treatment, meropenem was added. She received co-trimoxazole for 6 months without any untoward effects of therapy and responded well.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of disseminated nocardiosis in a renal transplant recipient

Hooda

Nandwani

Kaur³

et al. 2013

Medical Journal Armed Forces India

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Successful treatment of disseminated nocardiosis in a renal transplant recipient

Hooda

Nandwani

Kaur³

et al. 2013

Medical Journal Armed Forces India

View full text Add to dashboard Cite

“…Several antimicrobials-such as imipenem, meropenem, amikacin, ceftriaxone, cefotaxime, minocycline, moxifloxacin, dapsone, linezolid, and tigecycline-have been active in vitro and in animal models of nocardiosis (Cercenado et al, 2007;Threlkeld and Hooper, 1997;Vera-Cabrera et al, 2004;McNeil et al, 1995). These antibiotics and also clarithromycin have been clinically used and reported in some cases of nocardiosis (Beaman et al, 1992;Fihman et al, 2006;Moylett et al, 2003;Naik et al, 2007;Nizam et al, 2007). The current study confirms that linezolid and amikacin are the most effective treatment agents against the species isolated in the current patients, followed by imipenem and cotrimoxazole, with no significant recent changes in antimicrobial susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Revisiting nocardiosis at a tertiary care institution: Any change in recent years?

Galar

Martín‐Rabadán

Marı́n

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

To analyse relevant changes in incidence, clinical and microbiological characteristics of nocardiosis over the last 24 years at the current institution. Materials and methods: The clinical records of patients with nocardiosis (2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) were reviewed and then compared with a previous cohort (1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006). Nocardia isolates were identified by 5'-end-16S-rRNA-gene-PCR targeting the first 500 bp of the gene and sequencing. Susceptibility tests were determined by broth microdilution (CLSI guidelines). Results: Forty-two patients (64.3% male) with nocardiosis were evaluated in the recent cohort: 51.2% had COPD, 43.9% were on corticosteroid therapy and 31.7% had cancer. The incidence of nocardiosis varied from 6.3 to 7.1/100,000 admissions (p = 0.62). There was a decrease in HIV patients (27% vs. 4.9%, p = 0.01) and solid organ transplantation (SOT) recipients (18.9% vs. 2 .4%, p = 0.01). Cases with pulmonary involvement had increased (70.3% vs. 90.5%, p = 0.04). Nocardia species were similar but the most common were N. cyriacigeorgica (32.4% vs. 40.5%, p = 0.49) and N. farcinica (24.3% vs. 14.3%, p = 0.39). Antibiotic resistance remained stable: cotrimoxazole (10.8% vs. 5.7%, p = 0.68), imipenem (5.4% vs. 5.6%, p = 1.0); amikacin and linezolid were 100% active. No differences were found in breakthrough nocardiosis (21.6% vs. 9.8%, p = 0.21) or related mortality (21.6% vs. 21.4%, p = 1.0). The multivariate analysis confirmed that nocardiosis caused by N. farcinica is a risk factor for poor outcome (p = 0.045). Conclusions: Nocardiosis incidence has remained stable. It mainly affected elderly patients with chronic respiratory conditions and those on corticosteroid treatment. Infections in HIV and SOT patients have practically disappeared. Pulmonary involvement remains the most common area to be affected. Nocardiosis caused by N. farcinica is apparently a risk factor for poor clinical outcome.

show abstract

Invited Commentary on Treatment of Nocardia wallacei in an HIV Patient With Renal Failure

et al. 2016

View full text Add to dashboard Cite

Successful Treatment of Nocardia nova Bacteremia and Multilobar Pneumonia With Clarithromycin in a Heart Transplant Patient

Cited by 10 publications

References 13 publications

Successful treatment of disseminated nocardiosis in a renal transplant recipient

Successful treatment of disseminated nocardiosis in a renal transplant recipient

Revisiting nocardiosis at a tertiary care institution: Any change in recent years?

Invited Commentary on Treatment of Nocardia wallacei in an HIV Patient With Renal Failure

Contact Info

Product

Resources

About