Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

“…In previous studies, McGillis and Fein 15 and Rivard and Ozog 16 have also applied ALA for 30 minutes before illumination and exposition to light for 10 minutes in 3 fractions. In most of the previous studies the light sources used were lasers at 635 nm, Kübler et al, 17 Fan et al, 18 Kubler et al, 19 Sieron et al, 20 Sieroń et al, 21 Tsai et al, 22 Chen et al, 23 Lin et al, 24 and 585 nm, Franco, 25 Shafirstein et al 26 But, because of their bulkiness and high cost, we have chosen LED at 420 nm, like McGillis and Fein, 15 Rivard and Ozog, 16 Ericson et al, 27 Jerjes et al, 28 as it is cheaper, convenient, safe and easy to use in the treatment of OL and OLP. In the present study, 12 OL lesions were treated with 5-ALA mediated PDT, among which 2 (16.7%) showed complete response, 8 (66.67%) partial response and 2 (16.7%) no response.…”

Time-resolved autofluorescence spectroscopy for classifying normal and premalignant oral tissues

“…Furthermore, PpIX accumulation could be the result of a decreased conversion of PpIX to heme in tumor cells as a result of a decreased ferrochelatase activity [25,26]. Because PpIX has good fluorescent properties, its emission spectrum may be used as an indicator for carcinogenesis, and might also be effective for PDT [27]. On the other hand, it was suggested that even without ALA application, PpIX might still accumulate in abnormal tissues [28,29].…”

Photodynamic therapy with topical 5‐aminolevulinic acid as a post‐operative adjuvant therapy for an incompletely resected primary nasopharyngeal papillary adenocarcinoma: A case report

“…5-ALA-mediated PDT (5-ALA-PDT) is a well-tolerated and effective treatment for various malignancies and is suitable to treat the mucosal malignancy of the nasopharynx because of its adequate penetration depth [9,20,21]. For minimizing systemic unwanted photochemical skin reaction, a special formulation of topical 5-ALA preparation, which has been proved to be effective in superficial lessinvasive malignant lesions of the mucosa [21][22][23] was used as a photosensitizer to treat this patient.…”