Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin

Bolaños, José; Morgentaler, Abraham

doi:10.1016/j.eucr.2019.101078

Cited by 17 publications

(12 citation statements)

References 5 publications

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“…Dietary spermidine supplementation could be tested as an option prior to sexual activities. The first successful treatment has been reported with human chorionic gonadotropin [58], which seems to substantiate spermidine depletion in the etiology [59]. Moreover, Reisman presented successful treatment in 57% of POIS patients with the highly selective alpha 1 A-blocker, Sidosin [1].…”

Section: Testing This Hypothesis and Possible Interventionsmentioning

confidence: 89%

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Sonkodi

Kopa

Nyírády

2021

Cells

133

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Post orgasmic illness syndrome is a rare, mysterious condition with an unknown pathomechanism and uncertain treatment. The symptoms of post orgasmic illness syndrome last about 2–7 days after an ejaculation. The current hypothesis proposes that the primary injury in post orgasmic illness syndrome is an acute compression proprioceptive axonopathy in the muscle spindle, as is suspected in delayed onset muscle soreness. The terminal arbor degeneration-like lesion of delayed onset muscle soreness is theorized to be an acute stress response energy-depleted dysfunctional mitochondria-induced impairment of Piezo2 channels and glutamate vesicular release. The recurring symptoms of post orgasmic illness syndrome after each ejaculation are suggested to be analogous to the repeated bout effect of delayed onset muscle soreness. However, there are differences in the pathomechanism, mostly attributed to the extent of secondary tissue damage and to the extent of spermidine depletion. The spermidine depletion-induced differences are as follows: modulation of the acute stress response, flu-like symptoms, opioid-like withdrawal and enhanced deregulation of the autonomic nervous system. The longitudinal dimension of delayed onset muscle soreness, in the form of post orgasmic illness syndrome and the repeated bout effect, have cognitive and memory consequences, since the primary injury is learning and memory-related.

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Section: Testing This Hypothesis and Possible Interventionsmentioning

confidence: 89%

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Sonkodi

Kopa

Nyírády

2021

Cells

133

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“…10 However, few previous studies has shown that POIS is associated with testosterone. 11 In our case, though decline of his free testosterone level was modest, POIS associated with hypogonadism was suspected. Because the patient in our case was not married and did not have any desire to have babies, he chose TRT once or twice a month though we proposed selfinjection of hCG to avoid possible testicular atrophy due to the negative feedback of gonadotropin.…”

Section: Discussionmentioning

confidence: 52%

“…Bolanos and Morgentaler also reported a case of POIS associated with hypogonadism, which was successfully treated with administration of hCG. 11 Herein, we report a case of POIS associated with hypogonadism, which was different from allergy-associated condition, thereby treatments must be accurately selected according to pathophysiology. ≥1 of the following symptoms: sensation of flu-like state, extreme fatigue or exhaustion, weakness of musculature, experiences of feverishness or perspiration, mood disturbances and/or irritability, memory difficulties, concentration problems, incoherent speech, congestion of nose, or watery nose, itchy eyes 2…”

Section: Discussionmentioning

confidence: 99%

Case of post‐orgasmic illness syndrome associated with hypogonadism

2020

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Introduction Post‐orgasmic illness syndrome is a rare condition that occurs after ejaculation and persists for 2–7 days and is characterized by flu‐like symptoms, which can significantly reduce quality of life. Case presentation A 21‐year‐old unmarried man was referred to our hospital due to flu‐like symptoms that developed after ejaculation by masturbation and persisted for about 2 days. The patient’s free testosterone level was slightly lower than normal. Nonsteroidal anti‐inflammatory drugs were initially administered and helped relieve headache and muscle pain. Thereafter, the patient was able to ejaculate three times a week. In addition, after administering testosterone enanthate once or twice a month, his general fatigue significantly improved, and he could ejaculate every day. Conclusion The pathophysiology of post‐orgasmic illness syndrome has not been fully elucidated. The treatments for this condition must be accurately selected according to pathophysiology.

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“…3 A first successful treatment of POIS using HCG to a patient with testosterone (T) deficiency argues to multiply hormonal investigations in case of POIS. 14 At long last, various recounted adjuvant treatments have been proposed to treat POIS such as olive leaf, niacin, fenugreek, saw palmetto, and Wobenzym.…”

Section: Managementmentioning

confidence: 99%

The first Tunisian case of postorgasmic illness syndrome: A case report

Hamdi

Charaa

Brahmi

et al. 2021

Clinical Case Reports

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The Postorgasmic illness syndrome (POIS) is a rare syndrome, recently described by two Dutch doctors Waldinger and Schweizer in 2002 1 which includes a set of physical and cognitive symptoms, appearing electively after ejaculation. It can last for several days. 2 About only 50 cases have been reported in the medical literature. 2 The Prevalence of POIS remains unknown, likely underdiagnosed still mysterious, owing to a paucity of studies, but is most probably underreported. Symptoms occur for a few seconds to a few hours after ejaculation, whether after intercourse, masturbation, or spontaneously during sleep. These disorders reproduce almost every ejaculation.We report a rare case of POIS that illustrates the clinical polymorphism and therapeutic difficulties of this syndrome and discusses etiopathogenic hypotheses. | CLINICAL CASEMr. MT, 32-year-old has been married to his cousin for 11 years and has 5 children. He had no somatic or psychiatric history. The patient has a secondary school level and works as a builder. He has no history of past or present substance use a side of smoking weaned for 4 years.He was referred to the psychiatric examination at Mannouba's Razi Hospital, Tunisia, after seeing urologists, neurologists, and general practitioners. Indeed, a few

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Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin

Cited by 17 publications

References 5 publications

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Post Orgasmic Illness Syndrome (POIS) and Delayed Onset Muscle Soreness (DOMS): Do They Have Anything in Common?

Case of post‐orgasmic illness syndrome associated with hypogonadism

The first Tunisian case of postorgasmic illness syndrome: A case report

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