Successful treatment of primary hepatic amyloidosis with melphalan plus dexamethasone: a case report

啓市, 蔭地; 祥一, 高橋; 隆泰, 桑原; 友希, 木村; 隆広, 阿座上; 嘉男, 片村; 富貴子, 光井; 友和, 河岡; 宏美, 實藤; 道雄, 今村; 由育, 川上; 浩, 相方; 浩人, 石原; 光司, 有廣; 一彰, 茶山

doi:10.2957/kanzo.49.581

Kanzo

2008

DOI: 10.2957/kanzo.49.581

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Successful treatment of primary hepatic amyloidosis with melphalan plus dexamethasone: a case report

蔭地啓市¹,

高橋祥一²,

桑原隆泰³

et al.

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Cited by 2 publications

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“…There are no published papers that discuss the frequency of deposition in other organs. Table 2 describes the organs in the body that are subject to amyloid deposition (2)(3)(4)(17)(18)(19)(20)(21)(22)(23)(24)(25). Our patient is the only known patient with clinical symptoms of liver failure alone.…”

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Liver Biopsy-confirmed Primary Hepatic Amyloidosis with Only Jaundice As the Initial Symptom: An Autopsy Case Report

et al. 2022

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Amyloidosis causes various symptoms in many organs of the body, but amyloidosis that presents with liver damage alone has never been reported. We treated an 83-year-old man with amyloidosis who presented with liver damage alone. The liver damage in this patient was histologically proven to be liver amyloidosis. The administration of bortezomib and dexamethasone was not effective, so he rapidly died of liver failure. An aggressive liver biopsy should be considered when unexplained jaundice is observed.

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Liver Biopsy-confirmed Primary Hepatic Amyloidosis with Only Jaundice As the Initial Symptom: An Autopsy Case Report

et al. 2022

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AL amyloidosis that presented with marked hepatomegaly and polyclonal hypergammaglobulinemia

et al. 2017

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A 65-year-old woman presented with marked hepatomegaly and polyclonal hypergammaglobulinemia. Her total serum protein was 8.9 g/dL with 35.6% albumin and 40.2% (35.8 mg/mL) γ globulin. Alkaline phosphatase was 730 IU/L. The cranio-caudal liver span measured on computed tomography was 24.2 cm. A biopsy of the liver revealed replacement of the liver parenchyma with amorphous eosinophilic materials that were stained positive with Congo red and showed the apple-green birefringence of amyloid; amyloid deposits were also observed in the gastric mucosa and bone marrow (BM). Although immunofixation of the serum and urine detected no monoclonal component, the serum free light chain (FLC) assay revealed an excess

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Successful treatment of primary hepatic amyloidosis with melphalan plus dexamethasone: a case report

Cited by 2 publications

References 22 publications

Liver Biopsy-confirmed Primary Hepatic Amyloidosis with Only Jaundice As the Initial Symptom: An Autopsy Case Report

Liver Biopsy-confirmed Primary Hepatic Amyloidosis with Only Jaundice As the Initial Symptom: An Autopsy Case Report

AL amyloidosis that presented with marked hepatomegaly and polyclonal hypergammaglobulinemia

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