Successful treatment of psoriasis with adalimumab induced no changes in the gut microbiota

Intestinal microbiome characterization of adult Brazilian men with psoriasis compared to omnivore and vegetarian controls

“…The effect of psoriasis treatments on IM is a topic to be investigated and the participants used several different drugs; however, the use of adalimumab was not shown to modify the IM pattern in ten patients. 40 The participants of the present study also had low PASI scores, due to disease control with the established therapy. In fact, IM studies with patients with psoriasis without systemic treatment are needed.…”

Gut microbiome diversity and serum levels of lipopolysaccharide‐bound protein (LPB) in men with psoriasis under different systemic therapies

“…Recent studies suggest that systemic therapies for psoriasis can modulate the composition of the microbiome. 4,5 However, few studies explore GM, or LPS levels, in patients with psoriasis, considering their systemic treatments.…”

“…A study from Denmark that analyzed 10 patients under adalimumab did not find relevant changes in GM among the evaluated patients, despite their profile differing from the healthy controls. 4 The interpretation of the results from studies on GM must be cautious since GM is highly variable among the populations, and there is no well-defined standard healthy GM, nor was an absolutely beneficial bacteria recognized. This study was limited by the modest sample size, which included only adult men, as well as the absence of patients under anti-TNF drugs, phototherapy, and cyclosporine.…”