2016
DOI: 10.12659/ajcr.898611
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Successful Treatment of Pyoderma Gangrenosum with Cryoglobulinemia and Hepatitis C

Abstract: Patient: Male, 68Final Diagnosis: Pyoderma gangrenosumSymptoms: Worsening lower extremity woundMedication: —Clinical Procedure: —Specialty: Infectious DiseasesObjective:Rare diseaseBackground:Pyoderma gangrenosum is a rare, ulcerative cutaneous condition that was first described by Brocq in 1916. This diagnosis is quite challenging as the histopathological findings are nonspecific. Pyoderma gangrenosum is usually associated with inflammatory bowel disease, leukemia, and hepatitis C. We describe a rare clinical… Show more

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Cited by 7 publications
(3 citation statements)
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“…Several patients with HCV, HSV-1, and HSV-2 were identified. The association between HCV and ND has been reported, although due to limited evidence, it has been difficult to determine whether HCV truly increases the risk of ND [12][13][14]. Herpes infections have only been rarely reported in those with ND [15].…”
Section: Discussionmentioning
confidence: 99%
“…Several patients with HCV, HSV-1, and HSV-2 were identified. The association between HCV and ND has been reported, although due to limited evidence, it has been difficult to determine whether HCV truly increases the risk of ND [12][13][14]. Herpes infections have only been rarely reported in those with ND [15].…”
Section: Discussionmentioning
confidence: 99%
“…3 Elevated rheumatoid factor is also seen with type II cryoglobulinemia and can be associated with autoimmune conditions, with systemic lupus erythematosus and Sjogren’s syndrome more commonly associated. 2-4,6 Type III cryoglobulinemia is associated with monoclonal and polyclonal IgG and IgM immunoglobulins with rheumatoid factor activity. 2,5,7 This category of cryoglobulinemia is associated with autoimmune conditions; however, infectious etiology, especially HCV, has been associated with this subtype.…”
Section: Discussionmentioning
confidence: 99%
“…PG is not only a disease strictly confined to the skin, but rather represents a cutaneous manifestation of a generalized inflammatory reaction 7 . The exact cause of PG is poorly understood, but abnormal neutrophil functioning, genetic variation, and innate immune system dysregulation are all considered to have a part in the pathogenesis 9 . Recent investigations have also reported abnormal cellular immunity with anergy to recall antigens or an imbalance between helper T cells and suppressor T cells 10 .…”
Section: Discussionmentioning
confidence: 99%