Successful treatment of rapid growing mycobacterial infections with source control alone: Case series

Dumić, Igor; Lutwick, Larry I.

doi:10.1016/j.idcr.2021.e01332

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…NTM infection has similar smear positive to MTB, making it a difficult condition to evaluate and differentiate. In the previous studies, Dumic et al in 2021 [ 10 ] and Gopalaswamy et al in 2020 [ 11 ] found that adequate source control is a successful treatment option for rapidly growing NTM infection in immunocompetent patients in the absence of antimicrobial therapy, which is not the case in MTB infection.…”

Section: Discussionmentioning

confidence: 99%

An Immunocompetent Adult Male Presented with a Liver Abscess Caused by the Mycobacterium tuberculosis: A Case Report from India

Pawar,

Khadanga,

Singhai

2023

Case Reports in Infectious Diseases

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A liver abscess is a collection of purulent fluid in the liver parenchyma caused by a variety of etiological organisms such as bacteria, protozoa, and in rare occasions fungi. Mycobacterium tuberculosis (MTB) is a frequent and widespread infection in underdeveloped nations such as India, which can manifest in many ways. Tuberculosis mostly affects the lungs, although it can also affect any organ in the body. We are reporting a case of liver abscess caused by MTB infection in order to raise general awareness among physicians about the importance of suspecting and ruling out tuberculosis as a cause of liver abscess. To the best of our knowledge, there have been very few such cases reported from India/the rest of the world.

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Section: Discussionmentioning

confidence: 99%

An Immunocompetent Adult Male Presented with a Liver Abscess Caused by the Mycobacterium tuberculosis: A Case Report from India

Pawar,

Khadanga,

Singhai

2023

Case Reports in Infectious Diseases

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“…A biologics side-effects induced case ( Frizzell et al, 2020 ) showed that omadacycline monotherapy at a dose of 300 mg orally daily for 4 months was efficient against M. chelonae skin and skin structure infections without recurrence in a 1-year follow-up. Surgical debridement, incising, draining, and source control are recommended in treatment if there is extensive involvement of extra-pulmonary M. chelonae infection ( Dumic and Lutwick, 2021 ). Like M. marinum , thermal therapy was efficacious due to its thermal sensitivity.…”

Section: Main Textmentioning

confidence: 99%

“…The selection of antibiotics is mainly based on the results of drug susceptibility tests. According to the results (Chang and Whipps, 2015;Dumic and Lutwick, 2021), RGM is more sensitive to tigecycline, tobramycin, clarithromycin, and amikacin. However, the susceptibility profile varies from species to species.…”

Section: Rapid-growing Bacteria (Rgm)mentioning

confidence: 99%

Treatment of non-tuberculosis mycobacteria skin infections

Wang,

Jia,

2023

Front. Pharmacol.

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Non-tuberculosis mycobacteria (NTM) skin infections have become increasingly prevalent in recent years, presenting a unique challenge in clinical management. This review explored the complexities of NTM infections localized to the superficial tissues and provided valuable insights into the optimal therapeutic strategies. The antibiotic selection should base on NTM species and their susceptibility profiles. It is recommended to adopt a comprehensive approach that considers the unique characteristics of superficial tissues to improve treatment effectiveness and reduce the incidence of adverse reactions, infection recurrence, and treatment failure. Infection control measures, patient education, and close monitoring should complement the treatment strategies to achieve favorable outcomes in managing NTM skin infections. Further efforts are warranted to elucidate factors and mechanisms contributing to treatment resistance and relapse. Future research should focus on exploring novel treatment options, innovative drug development/delivery platforms, and precise methodologies for determining therapeutic duration. Longitudinal studies are also needed to assess the long-term safety profiles of the integrated approaches.

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“…Only one negative cultural exam on the sputum was performed to confirm NTM-LD recovery. It should be noted that, in some cases, successful treatment can be achieved with source control alone [59]. Table 1 summarizes the cases reported in the literature of NTM-LD that occurred in patients undergoing immunotherapy for cancer.…”

Section: Icis As Adjuvant In the Treatment Of Mtb/ntm Infectionmentioning

confidence: 99%

T-Cell Exhaustion in Mycobacterium tuberculosis and Nontuberculous Mycobacteria Infection: Pathophysiology and Therapeutic Perspectives

et al. 2021

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Immune exhaustion is a condition associated with chronic infections and cancers, characterized by the inability of antigen-specific T cells to eliminate the cognate antigen. Exhausted T cells display a peculiar phenotypic profile and exclusive functional characteristics. Immune exhaustion has been described in patients with Mycobacterium tuberculosis infection, and cases of tuberculosis reactivation have been reported in those treated with immune checkpoint inhibitors, drugs able to re-establish T-cells’ function. Exhausted T CD8+ cells’ profile has also been described in patients with infection due to nontuberculous mycobacteria. In this review, we initially provide an overview of the mechanisms leading to immune exhaustion in patients infected by Mycobacterium tuberculosis and nontuberculous mycobacteria. We then dissect the therapeutic perspectives related to immune checkpoint blockade in patients with these infections.

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Successful treatment of rapid growing mycobacterial infections with source control alone: Case series

Cited by 7 publications

References 20 publications

An Immunocompetent Adult Male Presented with a Liver Abscess Caused by the Mycobacterium tuberculosis: A Case Report from India

An Immunocompetent Adult Male Presented with a Liver Abscess Caused by the Mycobacterium tuberculosis: A Case Report from India

Treatment of non-tuberculosis mycobacteria skin infections

T-Cell Exhaustion in Mycobacterium tuberculosis and Nontuberculous Mycobacteria Infection: Pathophysiology and Therapeutic Perspectives

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