Successful Treatment of Recurrent Idiopathic Plantar Eccrine Hidradenitis With Colchicine

Pseudomonas-Contaminated Pool Triggering an Episode of Idiopathic Palmoplantar Hidradenitis

“…The pathogenesis of IPPH remains unknown. However, previous studies have presented several hypotheses including local thermal or mechanical trauma; pedal perspiration; moisture; intense physical activity; vibration; recent infections, especially streptococcal ones; recent vaccination; hypersensitivity reactions; and Pseudomonas infection of mechanically stressed areas of the skin, especially the soles, which could provide a portal of entry to the eccrine glands [ 2 , 3 , 6 , 8 , 9 , 10 , 11 , 12 ]. Some authors have reported a higher incidence of IPPH during the spring and summer seasons [ 10 , 11 ], leading to the hypothesis that the eccrine glands of pediatric patients may be functionally immature and therefore easily damaged by increases in temperature [ 10 ], mechanical trauma, and friction.…”

“…Neutrophilic eccrine hidradenitis is found mainly in patients with leukemia and other neoplastic diseases but can also arise secondary to chemotherapy drugs [ 21 ]. Affected locations are usually random and include the trunk, face, and extremities; most lesions present as tender erythematous papules and have extra histopathological features that differentiate them from IPPH [ 1 , 12 , 22 ]. Hand-foot disease from enteroviruses usually presents with asymptomatic vesicular lesions on the hands, feet, and oral cavity [ 3 ].…”

“…Histopathologic examination will reveal a primarily neutrophilic inflammatory infiltrate surrounding eccrine sweat glands [ 8 , 25 ]. Neutrophilic eccrine hidradenitis can be differentiated from IPPH by the presence of necrotic eccrine glands, syringosquamous metaplasia, and neutrophilic infiltrates affecting the ductal and secretory components of the eccrine coils with or without eosinophilic deposits in the basement membrane of the eccrine duct [ 1 , 12 , 21 , 22 ]. Histopathologic examination of IPPH will reveal inflammatory infiltrates surrounding the ductal component of eccrine coils and, frequently, neutrophilic abscesses adjacent to eccrine coils with or without septal panniculitis [ 1 , 12 , 21 , 22 ].…”

Neutrophilic eccrine hidradenitis in a patient with FOLFOX chemotherapy

“…Treatment serves only to relieve symptoms, and so the use of topical corticosteroids, cold compresses, and rest is recommended (1-4). Successful treatment with colchicine was reported in two cases (26,27). As a way to prevent possible recurrences, some authors suggest the use of oral dapsone (28).…”

Colchicine: an ancient drug with novel applications

“…Small series or individual report 44, b Idiopathic plantar eccrine hidradenitis Small series or individual report 45…”