Successful treatment of refractory adult-onset Still?s disease with infliximab. A prospective, non-comparative series of four patients

Kokkinos, Alexander; Iliopoulos, Alexios; Greka, Paraskevi; Efthymiou, Anna; Katsilambros, Nicholas; Sfikakis, Petros P.

doi:10.1007/s10067-003-0775-5

Cited by 78 publications

(36 citation statements)

References 16 publications

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“…Most patients diagnosed with AOSD recovered well and their function returned to normal. However, a consistent finding in the literature is that approximately one third of ASOD patients develop erosive Rheumatoid pattern polyarthritis [11][12][13][14][15] . This emphasises the importance of considering early AOSD diagnosis in any patient admitted with pyrexia of unknown origin with normal microbiological, autoimmune screen, body imaging, and bone marrow biopsy.…”

Section: Discussionmentioning

confidence: 70%

“…Approximately 35% of patients require DMARDs such as methotrexate, azathioprine, cyclosporine, and cylclophosphamide as maintenance therapy to combat the disease [13] . There is good evidence supporting the use of biological agents (mainly anti-TNF agents such us infliximab and etanercept) especially in refractory AOSD patients [13][14][15] . Most patients diagnosed with AOSD recovered well and their function returned to normal.…”

Section: Discussionmentioning

confidence: 99%

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Recurring Lower Abdominal Pain and Fever as Initial Presentation of Adult Onset Still’s Disease in the Absence of Arthralgia and Other System Involvement

Sreh

Saim

2017

European Journal of Case Reports in Internal Medicine

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A 34 year-old Afro-Caribbean female presented with recurring episodes of fever and lower abdominal pain over a period of two months not improving despite courses of antibiotics for possible recurrent urinary tract infections. On admission to hospital, patient was treated for a possible pyelonephritis or pelvic inflammatory disease (PID). Extensive investigations into possible source of infection were carried out. However, all of the repeated microbiological cultures were normal. Patient was investigated further for other possible causes including connective tissue disease, haematological disorders, or neoplasm, all of which were normal. Diagnosis of adult onset Still's disease (AOSD) was confirmed by a rheumatologist based on Yamaguchi's diagnostic criteria for AOSD alongside significantly raised serum ferritin. Patient was treated with steroids to which she showed remarkable clinical improvement alongside marked reduction in her serum ferritin levels.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Recurring Lower Abdominal Pain and Fever as Initial Presentation of Adult Onset Still’s Disease in the Absence of Arthralgia and Other System Involvement

Sreh

Saim

2017

European Journal of Case Reports in Internal Medicine

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“…[119] In a Greek case series, 4 patients refractory to high doses of corticosteroids and MTX responded favorably to treatment with inß iximab 3 mg/kg. [120] Inß iximab at a dose of 5 mg/kg was found to be effective in a patient with early AOSD who was steroid resistant and ineligible for MTX treatment. [121] In another study, after administering infliximab to a patient of AOSD with persistent proteinuria and arthritis, proteinuria was decreased and arthritis was improved.…”

Section: Treatmentmentioning

confidence: 97%

Adult - onsetStill′s disease: A review

Mehrpoor¹,

Owlia²

2009

Indian J Med Sci

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“…Прогноз благоприятный Полная ремиссия между эпизодами, которые имеют тенденцию к урежению и меньшей выраженности, чем начальные Может наблюдаться деструкция суставов, необходимо хирургическое вмешательство. Прогноз неблагоприятный ремиссию [64][65][66][67][68]. Интересно, что переход с одного ин-гибитора ФНО α на другой не так эффективен, как при РА [69].…”

Section: клиническийunclassified

Adult-onset Still’s disease

Srinivas¹,

Mouli²

2015

J Med Sci Res.

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A 24-year-old male presented with fever, sore throat, and arthralgias for duration of 4 weeks. Fever was high grade, intermittent, associated with maculopapular rash. He was admitted in outside hospital and was started on antibiotics, antituberculosis treatment (ATT), and anti-malarials. The patient was discharged without any improvement. He was then admitted in KIMS hospital, Secunderabad, with persistence of initial symptoms and he was investigated thoroughly for all possible infections, malignancies and autoimmune disease. Rheumatologist consultation was taken, Adult-onset Still’s disease (AOSD) has been considered as he fulfilled the criteria of AOSD. He was started on appropriate therapy and was discharged in stable condition. Keywords: Adult-onset Still’s disease; maculopapular rash; systemic inflammatory disorder

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Successful treatment of refractory adult-onset Still?s disease with infliximab. A prospective, non-comparative series of four patients

Cited by 78 publications

References 16 publications

Recurring Lower Abdominal Pain and Fever as Initial Presentation of Adult Onset Still’s Disease in the Absence of Arthralgia and Other System Involvement

Recurring Lower Abdominal Pain and Fever as Initial Presentation of Adult Onset Still’s Disease in the Absence of Arthralgia and Other System Involvement

Adult - onsetStill′s disease: A review

Adult-onset Still’s disease

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