Successful Treatment of Refractory Organic Catatonic Disorder With Repetitive Transcranial Magnetic Stimulation (rTMS) Therapy

Kate, Mahesh; Raju, Devinder; Vishwanathan, Vibhin; Khan, Fayaz; Nair, Girish K.; Thomas, Sanjeev V

doi:10.1176/jnp.23.3.jnpe2

Cited by 24 publications

(13 citation statements)

References 6 publications

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“…Notably, current treatments for catatonia include pharmacotherapy with benzodiazepines, and electroconvulsive treatment for drug resistant patients. However, use of rTMS and tDCS has been proposed in adults (Kate et al, 2011; Shiozawa et al, 2013) and in adolescents (Costanzo et al, 2015) as a safer and less invasive alternative to electroconvulsive treatment. The patient described by Costanzo et al (2015) was resistant to many different pharmacological treatments, including the administration of benzodiazepines, antipsychotics, antidepressants, anticonvulsants, and even a worsening in her conditions had been observed before deciding to assign her to a tDCS treatment.…”

Section: Methodsmentioning

confidence: 99%

Non-invasive Brain Stimulation for the Rehabilitation of Children and Adolescents With Neurodevelopmental Disorders: A Systematic Review

2019

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In the last years, there has been a growing interest in the application of different non-invasive brain stimulation techniques to induce neuroplasticity and to modulate cognition and behavior in adults. Very recently, different attempts have been made to induce functional plastic changes also in pediatric populations. Importantly, not only sensorimotor processing, but also higher-level functions have been addressed, with the aim to boost rehabilitation in different neurodevelopmental disorders. However, efficacy and safety of using these techniques in pediatric population is still debated. The current article aims to review the non-invasive brain stimulation studies conducted in pediatric populations using Transcranial Magnetic Stimulation or transcranial Direct Current Stimulation. Specifically, the available proofs concerning the efficacy and safety of these techniques on Autism Spectrum Disorder, Attention-deficit/hyperactivity disorder, Dyslexia, Tourette syndrome, and tic disorders are systematically reviewed and discussed. The article also aims to provide an overview about other possible applications of these and other stimulation techniques for rehabilitative purposes in children and adolescents.

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Section: Methodsmentioning

confidence: 99%

Non-invasive Brain Stimulation for the Rehabilitation of Children and Adolescents With Neurodevelopmental Disorders: A Systematic Review

2019

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“…Indeed, new therapeutic trials tested the repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique for indirect brain stimulation, as an emerging treatment modality for several neuropsychiatric conditions [82,83]. Three case reports used the rTMS for the treatment of catatonia, corroborating the efficacy of this technique for the treatment of this syndrome [84][85][86]. Although further randomized controlled trials are needed in order to determine the role of rTMS in the treatment of catatonia, this technique could be an innovative future direction for the treatment of catatonia in ASD patients.…”

Section: Future Directionsmentioning

confidence: 97%

Catatonia in Patients with Autism: Prevalence and Management

et al. 2014

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Although recent studies have shown that catatonia can occur in patients with autism spectrum disorders (ASDs), the overlap of the behavioral features between these disorders raises many diagnostic challenges. In fact, in clinical practice it is common to misinterpret catatonic symptoms, including mutism, stereotypic speech, repetitive behaviors, echolalia, posturing, mannerisms, purposeless agitation and rigidity, as features of ASDs. The current medical treatment algorithm for catatonia in ASDs recommends the use of benzodiazepines. Electroconvulsive therapy (ECT) is indicated when patients are unresponsive, or insufficiently responsive, to benzodiazepines. Other pharmacological options are also described for the treatment of catatonic patients resistant to benzodiazepines and ECT, and there is evidence for the effectiveness of a psychological treatment, co-occurring with medical treatments, in order to support the management of these patients. In this article we provide a summary of studies exploring catatonia in ASDs and our clinical experience in the management and treatment of this syndrome through the presentation of three brief case studies. Moreover, we review the mechanisms underlying symptoms of catatonia in ASDs, as well as the diagnostic challenges, providing an outline for the management and treatment of this syndrome in this clinical population.

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“…However, due to walking difficulties as a consequence of her clinical comorbidities, it was not feasible for the patient to attend the in-office TNS sessions on a 2-week daily basis, as previously employed in treatment paradigms [3][4][5][6]. Following previous safety results, with no life threatening, serious, or chronic adverse effect described so far [3], and other work with TNS administered in the home [7], at-home TNS was performed after the adequate training of the patient and a caregiver and written informed consent was provided (IRB approved).…”

Section: Department Of Neuroscience Child Neuropsychiatric Unit Bammentioning

confidence: 99%

“…Recently, a new therapeutic approach, aimed at modulating the cortical activity by non-invasive brain stimulation techniques, has been proposed. In adults, successful treatment of catatonic symptoms by repetitive transcranial magnetic stimulation (rTMS) [7,8] and transcranial direct current stimulation (tDCS) [9] over the frontal regions has been reported. Given growing evidence supporting the safety and tolerability of tDCS in children and adolescents, tDCS was administered over the dorsolateral prefrontal cortex to an adolescent with ASD and drug-resistant catatonia.…”

mentioning

confidence: 99%

Transcranial Direct Current Stimulation Treatment in an Adolescent with Autism and Drug-Resistant Catatonia

Costanzo¹,

Menghini²,

Casula³

et al. 2015

Brain Stimulation

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Catatonia is a syndrome characterized by alterations in motor, vocal and behavioral signs, generally occurring in the context of various medical and neuropsychiatric conditions [1]. Recent evidence suggests an increased recognition of catatonia as a comorbid syndrome of Autism Spectrum Disorder (ASD), with a prevalence ranging between 12% and 17% [2]. Although the nature of the association between these two conditions is still unclear, the cooccurrence of catatonic symptoms and ASD may be due to shared abnormalities in neuronal circuitries. Indeed, alteration in several areas of the prefrontal cortex was documented to play a critical role in catatonia [3] as well as in ASD [4].

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Successful Treatment of Refractory Organic Catatonic Disorder With Repetitive Transcranial Magnetic Stimulation (rTMS) Therapy

Cited by 24 publications

References 6 publications

Non-invasive Brain Stimulation for the Rehabilitation of Children and Adolescents With Neurodevelopmental Disorders: A Systematic Review

Non-invasive Brain Stimulation for the Rehabilitation of Children and Adolescents With Neurodevelopmental Disorders: A Systematic Review

Catatonia in Patients with Autism: Prevalence and Management

Transcranial Direct Current Stimulation Treatment in an Adolescent with Autism and Drug-Resistant Catatonia

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