Successful Treatment of Rhesus Monkeys for Septicemic Anthrax

Re, Lincoln; Klein, Frederick; Js, Walker; Bw, Haines; Wi, Jones; Bg, Mahlandt; Rh, Friedman

doi:10.21236/ad0448488

Cited by 22 publications

(16 citation statements)

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“…One approach has been used in the present study. (7) and in the elucidation of the mechanism of segregation distortion associated with the t-alleles (8). It will also finally solve the controversy about the position of the centromere in the IXth linkage group (9).…”

Section: Discussionmentioning

confidence: 91%

Cytological Identification of the Chromosome Carrying the IXth Linkage Group (Including H-2) in the House Mouse

Klein¹

1971

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 91%

Cytological Identification of the Chromosome Carrying the IXth Linkage Group (Including H-2) in the House Mouse

Klein¹

1971

Proc. Natl. Acad. Sci. U.S.A.

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“…The interaction of the S\4' with the ring is sure to be rich in 3D strong SA: effects. A laser experiment is being developed to elucidate the 3D nature of the interaction of a strong SA: with a localized highdensity feature such as a sphere (31). The 3D development strongly affects the interactions, with azimuthal (3D) modes growing and enhancing the "shredding" of the sphere.…”

Section: Supernovaementioning

confidence: 99%

Modeling Astrophysical Phenomena in the Laboratory with Intense Lasers

Remington

Arnett

Paul³

et al. 1999

Science

395

230

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Astrophysical research has traditionally been divided into observations and theoretical modeling or a combination of both. A component sometimes missing has been the ability to quantitatively test the observations and models in an experimental setting where the initial and final states are well characterized. Intense lasers are now being used to recreate aspects of astrophysical phenomena in the laboratory, allowing the creation of experimental test beds where observations and models can be quantitatively compared with laboratory data. Experiments are under development at intense laser facilities to test and refine our understanding of phenomena such as supernovae, supernova remnants, gamma-ray bursts, and giant planets.

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“…The tumor cell lines used in these studies were B16-BL6 [70], a highly invasive variant derived from the B16 malignant melanoma of C57BL/6 origin, 3LL-M2 [71], a metastatic variant of the Lewis lung carcinoma line of C57BL/6 origin, YAC-1 [72], a lymphoma induced by Moloney virus in A/SN mice, and P815 [73], a mastocytoma induced by methylcholanthrene in DBA/2 mice. All cell lines were propagated by serial passage in vitro in complete Eagle's minimum essential medium with Earle's salts, supplemented with 5% fetal bovine serum, L-glutamine, sodium pyruvate, nonessential amino acids, and twofold vitamin solution.…”

Section: Tumorsmentioning

confidence: 99%

Correlation of immunomodulatory and therapeutic activities of interferon and interferon inducers in metastatic disease

Black

Phillips

Tribble

et al. 1988

J of Cellular Biochemistry

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The mechanism of therapeutic activity of recombinant murine interferon-gamma (rMu IFN-gamma) and the IFN inducer polyinosinic-polycytidylic acid solubilized with poly-L-lysine in carboxy methyl cellulose (pICLC) in treating metastatic disease was investigated by comparing effector cell augmentation with therapeutic activity in mice bearing experimental lung metastases (B16-BL6 melanoma). Effector cell functions in spleen, peripheral blood, and lung (the organ with tumor) were tested after 1 and 3 weeks of rMu IFN-gamma or pICLC administration (intravenous, three times a week). In these studies, natural killer (NK), lymphokine-activated killer (LAK), cytolytic T lymphocytes (CTL) (against specific and nonspecific targets), and macrophage tumoricidal and tumoristatic activities were measured. rM IFN-gamma and pICLC had therapeutic activity and immunomodulatory activity in most assays of immune function examined. Specific CTL activity of pulmonary parenchymal mononuclear cells (PPMC), but not in splenocytes or peripheral blood lymphocytes (PBL), during week 3 and not during week 1, correlated with the therapeutic activity of rMu IFN-gamma and of pICLC. Macrophage tumoricidal activity in PPMC, but not in alveolar macrophages, also correlated with the therapeutic activity of rMu IFN-gamma, but the opposite was true for the therapeutic activity of pICLC. NK activity of PPMC, but not of splenocytes or PBL, during week 1 correlated with the therapeutic activity of pICLC; in contrast, NK activity at any site did not correlate with the therapeutic activity of rMu IFN-gamma. LAK activity at any site did not correlate with the therapeutic activity of either agent.

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Successful Treatment of Rhesus Monkeys for Septicemic Anthrax

Cited by 22 publications

References 0 publications

Cytological Identification of the Chromosome Carrying the IXth Linkage Group (Including H-2) in the House Mouse

Cytological Identification of the Chromosome Carrying the IXth Linkage Group (Including H-2) in the House Mouse

Modeling Astrophysical Phenomena in the Laboratory with Intense Lasers

Correlation of immunomodulatory and therapeutic activities of interferon and interferon inducers in metastatic disease

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