Successful treatment of severe form of bovine tropical theileriosis in dairy cattle and genotyping of Theileria annulata isolates of Tamil Nadu, India

Azhahianambi, P.; Madhanmohan, M.; Madan, N.; Kumaran, D.; M, Priyadharshini; Bharathi, Ramasamy; Senthilkumar, T.; Manoharan, S.

doi:10.1016/j.vprsr.2021.100628

Cited by 6 publications

(3 citation statements)

References 19 publications

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“…Buparvaquone, a known antiprotozoal, is used in the treatment of theileriosis, although it is not approved for the treatment of livestock in many countries, including European countries since it is not approved by the EMA (European Medicines Agency) [ 52 , 53 , 56 , 57 , 58 , 59 ]. Other substances are commonly used to treat theileriosis, such as oxytetracycline, imidocarb, halofunginone, or erythromycin, but to little effect [ 52 , 53 , 56 ]. According to the variation in clinical manifestations, additional drugs are used [ 57 , 58 ].…”

Section: Theileriosis Control Strategiesmentioning

confidence: 99%

“…In recent times, there has been investment in the development of vaccines, although their realized ability to protect against certain Theileria species, when animals are naturally infected, is not yet fully known [ 52 ]. Some of these vaccines are produced via the culture of cells infected with the attenuated T. annulata schizont [ 55 , 56 , 58 ]. On the other hand, development of subunit vaccines is generally regarded as problematic for apicomplexan parasites due their genetic diversity.…”

Section: Theileriosis Control Strategiesmentioning

confidence: 99%

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Genetic Resistance of Bovines to Theileriosis

Valente

Gomes

Coelho

et al. 2022

Animals

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Diseases caused by ticks have a high impact on the health, welfare, and productivity of livestock species. They are also an important cause of economic losses in farms worldwide. An example of such diseases is theileriosis, which can be controlled by drugs or vaccines, although these are not fully efficient. Therefore, there is a need to develop alternative and more sustainable and efficient complementary strategies. These may involve the identification and selection of animals more resistant to the disease. Several previous studies have identified significant differences in resistance between different breeds, with resistant breeds typically identified as those native to the region where they are being studied, and susceptible as those from exotic breeds. These studies have indicated that resistance traits are intrinsically related to the modulation of the immune response to infection. This review aims to systematize the general knowledge about theileriosis, emphasize resistance to this disease as a sustainable control strategy, and identify which traits of resistance to the disease are already known in cattle.

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Section: Theileriosis Control Strategiesmentioning

confidence: 99%

Section: Theileriosis Control Strategiesmentioning

confidence: 99%

Genetic Resistance of Bovines to Theileriosis

Valente

Gomes

Coelho

et al. 2022

Animals

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“…Theileria annulata is one of the main pathogens which are harmful to cattle, causing infected animals to show high fever, jaundice, hemoglobinuria, anemia, and swollen lymph nodes on the body surface [1][2][3][4][5]. Theileria annulata is an obligate intracellular protozoan parasite, which can induce bovine tropical theileriosis [6]. It is estimated that approximately 250 million cattle globally are at risk of tropical theileriosis, which has caused large economic losses to the cattle industry [7].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic profiling of bovine leucocytes transformed by Theileria annulata under BW720c treatment

Zhao

Liu

et al. 2022

Parasites Vectors

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Background When Theileria annulata infects host cells, it undertakes unlimited proliferation as tumor cells. Although the transformed cells will recover their limited reproductive characteristics and enter the apoptosis process after treatment with buparvaquone (BW720c), the metabolites and metabolic pathways involved are not clear. Methods The transformed cells of T. annulata were used as experimental materials, and the buparvaquone treatment group and DMSO control group were used. Qualitative and quantitative analysis was undertaken of 36 cell samples based on the LC–QTOF platform in positive and negative ion modes. The metabolites of the cell samples after 72 h of drug treatment were analyzed, as were the different metabolites and metabolic pathways involved in the BW720c treatment. Finally, the differential metabolites and metabolic pathways in the transformed cells were found. Results A total of 1425 metabolites were detected in the negative ion mode and 1298 metabolites were detected in the positive ion mode. After drug treatment for 24 h, 48 h, and 72 h, there were 56, 162, and 243 differential metabolites in negative ion mode, and 35, 121, and 177 differential metabolites in positive ion mode, respectively. These differential metabolites are mainly concentrated on various essential amino acids. Conclusion BW720c treatment induces metabolic disturbances in T. annulata-infected cells by regulating the metabolism of leucine, arginine, and l-carnitine, and induces host cell apoptosis. Graphical abstract

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