Successful treatment of three patients with organizing pneumonia associated with rheumatoid arthritis using clarithromycin and prednisolone

Ohe, Masashi; Shida, Haruki; Horita, Tetsuya; Ito, Kenichiro; Sugiura, Masahiro; Hattori, Atsuo; Oku, Kenji

doi:10.5582/ddt.2017.01043

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The anti-inflammatory effects of macrolides are the basis of their effectiveness in the treatment of organising pneumonia14–16 and other diseases including chronic obstructive pulmonary disease, cystic fibrosis and panbronchiolitis. Macrolides have been successfully used to treat cryptogenic and secondary organising pneumonia either alone or in combination with corticosteroids 17–19. We speculate that our patient had a good response to azithromycin due to the anti-inflammatory properties of the macrolides.…”

Section: Discussionmentioning

confidence: 72%

Acute fibrinous organising pneumonia presenting as a cavitary lung lesion and treatment response to azithromycin

et al. 2019

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Acute fibrinous organising pneumonia is distinct from the classic diffuse alveolar damage, organising pneumonia and eosinophilic pneumonia. A 52-year-old woman presented with fever, productive cough, night sweats and left-sided pleuritic chest pain for a week. Physical examination was significant only for decreased breath sounds in the left infraclavicular area laterally. Imaging studies revealed a peripheral thick-walled left upper lobe cavitary lesion, left lower lobe consolidation and an enlarged subcarinal lymph node. She was treated with doxycycline for 10 days without improvement. Pertinent laboratory tests, microbiologic workup and fibre-optic bronchoscopy were non-diagnostic and a CT-guided left upper lobe lung biopsy revealed acute fibrinous organising pneumonia. She was treated with azithromycin with complete resolution of symptoms. To our knowledge, this is the first reported case of acute fibrinous organising pneumonia presenting as a cavitary lung lesion and the first with treatment response to azithromycin.

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Section: Discussionmentioning

confidence: 72%

Acute fibrinous organising pneumonia presenting as a cavitary lung lesion and treatment response to azithromycin

et al. 2019

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“…Then 122 articles were selected for reading. 2 , 4 , 5 , 6 , 7 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ,…”

Section: Resultsunclassified

Systematic Review of Systemic Corticosteroids for Treatment of Organizing Pneumonia

Cendon¹,

Codern²,

Rosa³

et al. 2022

Open Respiratory Archives

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“…In cases where the dominant histology pattern is characterized by lymphoid hyperplasia-follicular bronchiolitis-a response to systemic steroids and/or low-dose macrolides is frequently observed. 86 Treatment with rituximab could represent a therapeutic option in subjects with aggressive, severe disease 87 ; in most severe cases, lung transplantation may be proposed. The prevalence and clinical implications of small airways involvement in SSc are still to be fully elucidated 88 ; Bonifazi et al recently demonstrated that small airways dysfunction, at IOS assessment, was present in more than 20% of the SSc patients, with a prevalence fivefold higher than in healthy subjects 89 and was significantly associated with worse respiratory-related quality of life.…”

Section: Ctd-related Bronchiolitismentioning

confidence: 99%

Bronchiolitis and Bronchiolar Disorders

Ravaglia¹,

Poletti

2020

Semin Respir Crit Care Med

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Bronchioles are noncartilaginous small airways with internal diameter of 2 mm or less, located from approximately the eighth generation of purely air conducting airways (membranous bronchioles) down to the terminal bronchioles (the smallest airways without alveoli) and respiratory bronchioles (which communicate directly with alveolar ducts and are in the range of 0.5 mm or less in diameter). Bronchiolar injury, inflammation, and fibrosis may occur in myriad disorders including connective tissue diseases, inflammatory bowel diseases, lung transplant allograft rejection, graft versus host disease in allogeneic stem cell recipients, neuroendocrine cell hyperplasia, infections, drug toxicity (e.g., penicillamine, busulfan), inhalation injury (e.g., cigarette smoke, nylon flock, mineral dusts, hard metals, Sauropus androgynous); idiopathic, common variable immunodeficiency disorder, and a host of other disorders or insults. The spectrum of bronchiolar disorders is wide, ranging from asymptomatic to fatal obliterative bronchiolitis. In this review, we discuss the salient clinical, radiographic, and histological features of these diverse bronchiolar disorders, and discuss a management approach.

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Successful treatment of three patients with organizing pneumonia associated with rheumatoid arthritis using clarithromycin and prednisolone

Cited by 5 publications

References 16 publications

Acute fibrinous organising pneumonia presenting as a cavitary lung lesion and treatment response to azithromycin

Acute fibrinous organising pneumonia presenting as a cavitary lung lesion and treatment response to azithromycin

Systematic Review of Systemic Corticosteroids for Treatment of Organizing Pneumonia

Bronchiolitis and Bronchiolar Disorders

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