Successful Treatment of Trigeminal Trophic Syndrome in a 6-Year-Old Boy With Negative Pressure Wound Therapy

Fredeking, Arden E.

doi:10.1001/archderm.144.8.984

Cited by 27 publications

(29 citation statements)

References 13 publications

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“…Transcutaneous electrical nerve stimulation may lead to improvement, but relapse is common after discontinuation . Electrical stimulation, negative pressure therapy, and autologous epidermal cell transplant have been investigated with varying degrees of success . Antibiotic therapy, vitamin B treatment, hydrocolloid dressings, cervical sympathectomy, and transcutaneous electrical nerve stimulation to improve blood supply have been reported to result in healing of the wound with good outcome in single case reports .…”

Section: Management Options For Trigeminal Trophic Syndromementioning

confidence: 99%

Trigeminal trophic syndrome: an updated review

2018

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Trigeminal trophic syndrome (TTS) is a rare disease process that is thought to occur after insult to the trigeminal nerve. The earliest descriptions of this condition were provided in the early 20th century, yet it remains relatively unknown, with approximately 200 cases since described. Most commonly seen in older women, TTS characteristically involves persistent facial ulceration with loss of sensation and paresthesia along the distribution of the trigeminal dermatome. Ulceration often occurs in the alar region, following self-manipulation in response to paresthesias. Time of onset of TTS after trigeminal insult may vary from weeks to decades, and emergence of ulceration may be associated with psychiatric disorders. Diagnosis is clinical and made by exclusion of similarly presenting conditions. Histology is nonspecific yet necessary to exclude other causes of facial ulceration. Although there is not yet a standard management strategy, a number of successful approaches have been reported including pharmaceutical and surgical interventions, installation of a protector, and transcutaneous nerve stimulation. However, because of the self-inflicted manifestations of this disorder, behavioral modifications remain of the utmost importance. This review serves to address the history, epidemiology, pathogenesis, clinical presentation, histology, diagnosis, differential diagnosis, and management options for TTS.

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Section: Management Options For Trigeminal Trophic Syndromementioning

confidence: 99%

Trigeminal trophic syndrome: an updated review

2018

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“…Successful treatment of TTS in a 6-year-old boy with negative pressure wound therapy has been reported. [10]…”

Section: Discussionmentioning

confidence: 99%

Trigeminal trophic syndrome

Kumar

Thomas

2014

Indian J Dermatol

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Trigeminal trophic syndrome (TTS) is a rare cause of facial ulceration, consequent to damage to the trigeminal nerve or its central sensory connections. We reporta case of TTS in a 48-year-old woman with Bell's palsy following herpes zoster infection. The patient was treated and counseled. There hasnot been any recurrence for 1 year and the patient is being followed-up. The diagnosis of TTS should be suspected when there is unilateral facial ulceration, especially involving the ala nasi associated with sensory impairment.

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“…Carbamazepine is believed to influence both the paraesthesia and the behavioural factors in this condition, 12,13 and appears to be most effective in cases in which the patient acknowledges a sense of irritation and admits to picking. Successful treatment of trigeminal trophic syndrome with negative pressure wound therapy was recently reported in a 6-year-old boy, 14 while autologous epidermal cells have been reported to induce healing in a case of trigeminal trophic syndrome with a relatively limited area of ulceration. 15 The poor response of our patient to various treatment modalities is likely to have been contributed to by other compounding factors, such as alcoholism, underlying depression, poor nutrition, social isolation and the compulsive urge to pick at his skin.…”

Section: Discussionmentioning

confidence: 99%

Trigeminal trophic syndrome treated with thermoplastic occlusion

Kurien

Damian

Moloney

2011

Australasian Journal of Dermatology

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A 72-year-old man with a history of thrombotic CVA causing lateral medullary infarction presented with non-healing ulcers of the right side of the face of 5 months' duration. After extensive investigations, a diagnosis of trigeminal trophic syndrome was made. The ulcers progressed relentlessly despite amitriptyline and gabapentin, and he was treated with a combination of carbamazepine and thermoplastic mask occlusion of the right side of his face. Over the next 10 weeks the shallower facial ulcers began to diminish in depth and diameter, and the deeper ulcers stopped progressing. Although the patient showed early signs of healing, he died because of complications from the CVA.

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Successful Treatment of Trigeminal Trophic Syndrome in a 6-Year-Old Boy With Negative Pressure Wound Therapy

Cited by 27 publications

References 13 publications

Trigeminal trophic syndrome: an updated review

Trigeminal trophic syndrome: an updated review

Trigeminal trophic syndrome

Trigeminal trophic syndrome treated with thermoplastic occlusion

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