Successful treatment of two refractory venous stasis ulcers treated with a novel poly-N-acetyl glucosamine-derived membrane

Maus, Erik A.

doi:10.1136/bcr.03.2012.6091

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Materials consisting of sNAG have been shown to activate platelets and erythrocytes and thereby are effective hemostatic agents. Using hemostatic patches containing sNAG, superior and more rapid wound closure has been reported in two refractory venous stasis ulcers . Modulations of the initial inflammatory response as well as platelet activation have been hypothesized as the main mechanisms of action.…”

Section: Discussionmentioning

confidence: 99%

Poly‐N‐acetyl glucosamine nanofibers for negative‐pressure wound therapies

Fulco

Erba

Valeri

et al. 2015

Wound Repair Regeneration

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The wound healing promoting effect of negative wound pressure therapies (NPWT) takes place at the wound interface. The use of bioactive substances at this site represents a major research area for the development of future NPWT therapies. To assess wound healing kinetics in pressure ulcers treated by NPWT with or without the use of a thin interface membrane consisting of poly-N-acetyl glucosamine nanofibers (sNAG) a prospective randomized clinical trial was performed. The safety of the combination of NPWT and sNAG was also assessed in patients treated with antiplatelet drugs. In the performed study, the combination of NPWT and sNAG in 10 patients compared to NPWT alone in 10 patients promoted wound healing due to an improved contraction of the wound margins (p = 0.05) without a change in wound epithelization. In 6 patients treated with antiplatelet drugs no increased wound bleeding was observed in patients treated by NPWT and sNAG. In conclusion, the application of thin membranes of sNAG nanofibers at the wound interface using NPWT was safe and augmented the action of NPWT leading to improved wound healing due to a stimulation of wound contraction.

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Section: Discussionmentioning

confidence: 99%

Poly‐N‐acetyl glucosamine nanofibers for negative‐pressure wound therapies

Fulco

Erba

Valeri

et al. 2015

Wound Repair Regeneration

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“…Talymed ® is composed of nanofibers of poly- N -acetyl glucosamine, isolated from microalgae, and indicated for the treatment of several complex wounds. This is able to promote wound healing mainly by re-epithelialisation, stimulation of angiogenesis, and cell proliferation [ 35 , 36 ].…”

Section: Medical Devices For Wound Healingmentioning

confidence: 99%

Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

et al. 2020

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Chronic wounds, such as pressure ulcers, diabetic ulcers, venous ulcers and arterial insufficiency ulcers, are lesions that fail to proceed through the normal healing process within a period of 12 weeks. The treatment of skin chronic wounds still represents a great challenge. Wound medical devices (MDs) range from conventional and advanced dressings, up to skin grafts, but none of these are generally recognized as a gold standard. Based on recent developments, this paper reviews nanotechnology-based medical devices intended as skin substitutes. In particular, nanofibrous scaffolds are promising platforms for wound healing, especially due to their similarity to the extracellular matrix (ECM) and their capability to promote cell adhesion and proliferation, and to restore skin integrity, when grafted into the wound site. Nanotechnology-based scaffolds are emphasized here. The discussion will be focused on the definition of critical quality attributes (chemical and physical characterization, stability, particle size, surface properties, release of nanoparticles from MDs, sterility and apyrogenicity), the preclinical evaluation (biocompatibility testing, alternative in vitro tests for irritation and sensitization, wound healing test and animal wound models), the clinical evaluation and the CE (European Conformity) marking of nanotechnology-based MDs.

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