Successful treatment with ALA-PDT of Refractory condyloma acuminatum of the whole anterior urethra

Chen, Nian; Cheng, Qi; Zeng, Qianwen; Lei, Xia

doi:10.1016/j.pdpdt.2020.101918

Cited by 11 publications

(3 citation statements)

References 3 publications

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“…With an incidence of up to 12.5%, most intraurethral CA occur in the urethral meatus [1,2]. Because of the mucosal immune system, isolated intraurethral CA without external genitalia lesions is a relatively rare occurrence [3]. Therefore, due to the high rate of recurrence, a combined therapeutic strategy (surgery and medical treatment) is more effective than a single modality [4].…”

Section: Discussionmentioning

confidence: 99%

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Kim

2023

Urogenit Tract Infect

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Condyloma acuminatum is a common sexually transmitted disease caused by the human papillomavirus and with a high recurrence rate in the urethra. We report the intraurethral instillation of 5-fluorouracil cream for intraurethral condyloma acuminatum with suprapubic cystostomy after transurethral surgery. A 64-year-old man had gross hematuria for several days. At cystourethroscopy, multiple papillary mass lesions were identified on the entire urethra. Transurethral resection of the urethral masses confirmed the diagnosis of condyloma acuminatum. However, recurrent multiple warts were identified on the whole urethra. After re-surgery, intraurethral instillation of 5-fluorouracil cream with suprapubic cystostomy was achieved to prevent a recurrence. After one year of 5-fluorouracil instillation, there was no recurrence of intraurethral condyloma acuminatum.

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Section: Discussionmentioning

confidence: 99%

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Kim

2023

Urogenit Tract Infect

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“…Another case report by Chen et al had similar findings. 29 Side effects of PDT include burning at the treatment site, edema, and dysuria. 23,24,30 One study reported two patients who went into urinary retention and required short-term catheterization likely secondary to periurethral edema.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Treatment of urethral and bladder condyloma acuminata

Patel,

Marantidis,

Davenport

et al. 2023

UNOAJ

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Human papillomavirus (HPV) is one of the most prevalent sexually transmitted infections in the world and rarely may affect the urethra and bladder. This article describes two cases of bladder HPV infection managed at our institution and summarizes literature describing the management of lower urinary tract HPV lesions published in PubMed (MEDLINE) since 2010. Articles were selected after performing a scoping literature review using the search terms “human papillomavirus”, “condyloma”, “bladder” and/or “urethra”. Thirty-five articles were included in the review with treatment options including surgical excision, ablative therapy, photodynamic therapy, and topical agents.

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“…Photodynamic therapy (PDT) is noninvasive and specific to the target tissue and is mainly used for the treatment of certain actinic keratoses, superficial nonmelanoma skin tumors, photoaging, acne, sebaceous gland hyperplasia, and other hyperplasia as well as inflammatory skin diseases [9][10][11][12][13][14][15]. In recent years, PDT has been widely applied in the management of diseases such as condyloma acuminatum and common warts [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of 5-Aminolevulinic Acid Photodynamic Therapy with Transfer Factor Capsules in the Treatment of Multiple Plantar Warts

Qiu

et al. 2022

BioMed Research International

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Background. Plantar warts are a common cutaneous disease of the sole of the foot caused by human papillomavirus. Photodynamic therapy has gained increasing attention in the treatment of plantar warts. Objective. To investigate the effect of photodynamic therapy combined with transfer factor capsules in the treatment of multiple plantar warts. Methods. Sixty-one patients with multiple plantar warts who visited our outpatient department from September 2017 to August 2019 were randomly divided into two groups. Twenty-three patients received photodynamic therapy (treatment group) and thirty-eight received cryotherapy (control group). Both groups also received immune modulator transfer factor capsules. Skin lesion score, numeric rating scale- (NRS-) 10 score, recurrence rate, adverse reactions, and Dermatology Life Quality Index (DLQI) were analyzed in both groups. Results. The mean skin lesion score improved from 13.39 ± 3.88 before treatment to 1.48 ± 2.50 after the last treatment in the treatment group and from 12.47 ± 2.99 before treatment to 4.47 ± 3.67 after the last treatment in the control group. The success rate after 3 months of treatment was 86.96% in the treatment group and 39.47% in the control group. After 3 months of follow-up, the recurrence rate was significantly lower in the treatment group (20%) than in the control group (53.33%). The mean DLQI score at three months after treatment was significantly lower in the treatment group ( 3.61 ± 1.16 ) than in the control group ( 6.31 ± 2.59 ). Conclusion. Photodynamic therapy combined with immunomodulators significantly increased the cure rate and reduced the recurrence rate of multiple plantar warts compared with traditional cryotherapy combined with immunomodulators.

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Successful treatment with ALA-PDT of Refractory condyloma acuminatum of the whole anterior urethra

Cited by 11 publications

References 3 publications

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Intraurethral Instillation of 5-fluorouracil with Suprapubic Cystostomy for Intraurethral Condyloma Acuminatum

Treatment of urethral and bladder condyloma acuminata

Effect of 5-Aminolevulinic Acid Photodynamic Therapy with Transfer Factor Capsules in the Treatment of Multiple Plantar Warts

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