Successful treatment with diclofenac sodium 1% gel of a case of suspected Darier disease

Kaga, Maya; Ikeda, Shigaku

doi:10.1111/ced.13727

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Diclofenac sodium 1% was used twice a day in 1 patient for 1 month with marked flattening of the lesions except at the soles. 25 Tacalcitol Tacalcitol was used in a 39-year-old female with substantial improvement and no relapse after 5 months. 26 Tacrolimus Tacrolimus 0.1% was used twice a day in a 22-year-old female with remission after 8 weeks and no relapse for up to 1 year after the treatment.…”

Section: Diclofenac Sodiummentioning

confidence: 99%

Management of Darier disease: A review of the literature and update

Haber¹,

Dib²

2021

IJDVL

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Darier disease (DD) is a rare type of inherited keratinizing disorder with no definitive therapeutic approach. The objective of this study is to provide a detailed literature review of all the available treatment modalities of Darier disease, including those that are both surgical and non surgical, to compare their efficacies and to propose a novel therapeutic approach. A complete search of the literature for all articles describing the different treatments of Darier disease, with no restrictions on patients’ ages, gender or nationalities, was performed with the use of PubMed. A total of 68 articles were included in the study: 3 prospective studies, 44 case reports/case series and 21 letters/correspondences/clinical images. The treatments described were topical, oral or physical. Retinoids (isotretinoin, tazarotene and adapalene) and fluorouracil were the two most effective topical treatments. Oral retinoids were the most effective oral therapy and were prescribed in the cases of generalized Darier disease. For localized and resistant skin lesions, physical therapies including surgical excision, dermabrasion and CO2 laser ablation were the first line choices. Limitations of this article include the inability to verify the accuracy of the published data, the relatively small sample size, the absence of randomized controlled clinical trials and possible unidentified confounding factors in various studies. In every therapeutic approach to Darier disease, consideration of patient comorbidities, disease distribution, severity and treatment accessibility is essential. Large and randomized clinical trials are necessary for the comparison of the efficacy and the safety of all the treatments of Darier disease and settling a consensus for management.

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Section: Diclofenac Sodiummentioning

confidence: 99%

Management of Darier disease: A review of the literature and update

Haber¹,

Dib²

2021

IJDVL

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“…En aplicación tópica, el uso de emolientes con urea 20% o ácido láctico 12% sirve para disminuir la hiperqueratosis. También se ha reportado respuesta con corticosteroides de mediana y alta potencia, diclofenaco sódico 1%, 5-fluorouracilo 1%, tacrolimus 0.1% y/o retinoides (tretinoína 0.05%, adapaleno 0.1%, tazaroteno 0.1%) [9][10][11] .…”

Section: La Ed También Conocida Como Queratosis Folicular O Disqueratosis Folicular Es Una Genodermatosisunclassified

Enfermedad de Darier lineal, causa poco frecuente de prurito en el adulto: serie de casos

Gallmann¹,

Brusa²,

Andrade³

et al. 2020

MCUT

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Inherited Acantholytic Disorders

Zamiri

2024

Rook's Textbook of Dermatology

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Darier disease (DD) and Hailey–Hailey disease (HHD) are autosomal dominant disorders characterised by epidermal acantholysis. They have a similar molecular pathogenesis, with mutations in intracellular calcium pumps of the endoplasmic reticulum ( SERCA2 ) and Golgi ( SPCA1 ), respectively. DD presents with persistent, hyperkeratotic papules in a seborrhoeic distribution, associated with nail changes and palmar pitting. HHD presents with painful, mainly flexural, erosions. In both, secondary infection is common and hypertrophic flexural disease can be disabling. Histologically, both are characterised by loss of epidermal intercellular adhesion (acantholysis). DD may be accompanied by neuropsychiatric symptoms such as depression, epilepsy, learning disabilities or bipolar disease. First line topical treatment is with emollients, antimicrobials and corticosteroids. Oral antibiotics are often necessary for exacerbations; other systemic options include retinoids and ciclosporin. Physical measures such as laser resurfacing, photodynamic therapy, botulinum toxin and surgical interventions can be considered in refractory cases.

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Successful treatment with diclofenac sodium 1% gel of a case of suspected Darier disease

Abstract: Click https://www.wileyhealthlearning.com/ced.aspx for the corresponding questions to this CME article.

Cited by 5 publications

References 6 publications

Management of Darier disease: A review of the literature and update

Management of Darier disease: A review of the literature and update

Enfermedad de Darier lineal, causa poco frecuente de prurito en el adulto: serie de casos

Inherited Acantholytic Disorders

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