Successful treatment with imatinib of lymphomatoid papulosis associated with myeloproliferative hypereosinophilic syndrome with PDGFRA rearrangement

Lymphomatoid papulosis associated with myeloid neoplasm with eosinophilia and FIP1L1::PDGFRA rearrangement: Successful imatinib treatment in two cases

“…Among them, seven patients were treated with imatinib, five of whom expressed FIP1L1::PDGFRA rearrangement, and achieved a good response on both LyP and HES in all cases (Table 1). 5–11 …”

“…Among them, seven patients were with imatinib, five of whom expressed FIP1L1::PDGFRA rearrangement, and achieved a good response on both LyP and HES in all cases (Table 1). [5][6][7][8][9][10][11] Why LyP can be associated with (or causal of) HES is still uncertain. HE can be secondary to clonal T-cell expansion, as in its lymphocytic variant, in which the atypical lymphocytes have been shown to release eosinophilopoietic cytokines, such as IL-5 and IL-3.…”

Solitäre ulzeronekrotische Papel am Augenlid

“…In Einzelfällen können topische oder intraläsionale Glukokortikosteroide, Methotrexat oder Phototherapie mit PUVA oder UBV311 angezeigt sein [2]. Kürzlich wurde über die erfolgreiche Therapie einer LyP mit Imatinib im Rahmen einer myeloproliferativen Erkrankung berichtet [7].…”

Solitary ulcero‐necrotic papule on the eyelid

“…In individual cases, topical or intralesional glucocorticosteroids, methotrexate or phototherapy with PUVA or UBV311 may be indicated [2]. Recently, successful treatment of LyP with imatinib in myeloproliferative disease has been reported [7].…”