Successful Treatment with Infliximab and Low-dose Methotrexate in a Japanese Patient with Familial Mediterranean Fever

Nakamura, Akinori; Matsuda, Masayuki; Tazawa, Ko-ichi; Shimojima, Yasuhiro; Ikeda, Shu‐ichi

doi:10.2169/internalmedicine.46.0064

Cited by 30 publications

(18 citation statements)

References 15 publications

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“…We used infliximab first because the effectiveness of the drug in a Japanese FMF patient was previously reported (19). Infliximab dramatically alleviated the patient's symptoms.…”

Section: Discussionmentioning

confidence: 99%

An Atypical Familial Mediterranean Fever Patient Who Developed Ulcers in the Terminal Ileum and Recurrent Abscess-like Lesions in Multiple Organs

et al. 2012

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We herein describe the case of a 25-year-old woman who suffered from atypical familial Mediterranean fever for more than a decade. She presented with a periodic fever, abdominal pain and persistent ulcers in the terminal ileum. Colchicine was effective, and familial Mediterranean fever was diagnosed. A genetic study showed a heterozygous E148Q mutation in the MEFV gene. Multiple, recurrent, abscess-like lesions developed asynchronously in the spleen, liver, and a lung. Infliximab was administered when colchicine treatment became ineffective. However, infliximab treatment soon became ineffective, probably because antibodies were generated against it. Therefore, etanercept treatment was started, and the patient showed an immediate response.

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“…We used infliximab first because the effectiveness of the drug in a Japanese FMF patient was previously reported (19). Infliximab dramatically alleviated the patient's symptoms.…”

Section: Discussionmentioning

confidence: 99%

An Atypical Familial Mediterranean Fever Patient Who Developed Ulcers in the Terminal Ileum and Recurrent Abscess-like Lesions in Multiple Organs

et al. 2012

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“…However, it is difficult to obtain anakinra in Japan. Anti-TNF agents, including infliximab, etanercept, adalimumab and golimumab, can also be employed to control FMF attacks quite effectively (19,20). In the present case, following the administration of 1 mg of colchicine and treatment with infliximab for seven months, we increased the dose of colchicine to 1.5 mg and discontinued infliximab.…”

Section: Discussionmentioning

confidence: 70%

Usefulness of Small Intestinal Endoscopy in a Case of Adult-onset Familial Mediterranean Fever Associated with Jejunoileitis

et al. 2015

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A 66-year-old Japanese man consulted our institution due to paroxysmal and repetitive bouts of fever and abdominal pain that had persisted for more than one week. Capsule and double-balloon endoscopy (DBE) showed petal-shaped mucosal redness with white hemming in the jejunum and ileum, and histopathology of the biopsy specimens revealed villous atrophy and cryptitis with extensive severe neutrophil infiltration. A genetic examination disclosed compound heterozygous MEFV mutations (E84K, P369S), and familial Mediterranean fever was diagnosed. Treatment with colchicine and infliximab was very effective in inducing the complete disappearance of symptoms and normalization of the endoscopic findings. To the best of our knowledge, this is the first report to describe the findings of small intestinal endoscopic images obtained using capsule and DBE.

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“…[16] Tumor necrosis factor alpha inhibitors have been reported to be effective in the treatment of FMF in many case reports. [4,[9][10][11][12] Most of the patients were treated with infliximab, and one patient was treated with etanercept. [9] Our patient responded to TNF-α (adalimumab) treatment.…”

Section: Discussionmentioning

confidence: 99%

“…There are a few reports of FMF cases that were treated with a tumor necrosis factor alpha (TNF-α) inhibitor. [4,[9][10][11][12] In this article, we report on a patient who was followed up after a diagnosis of AS for two years, diagnosed with FMF in our clinic and who responded to adalimumab treatment.…”

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confidence: 99%

A Case with Familial Mediterranean Fever which Responds Well to Adalimumab Treatment

Ortancil¹

2011

Turk J Rheumatol

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Successful Treatment with Infliximab and Low-dose Methotrexate in a Japanese Patient with Familial Mediterranean Fever

Abstract: We report a Japanese patient with familial Mediterranean fever (FMF)

Cited by 30 publications

References 15 publications

An Atypical Familial Mediterranean Fever Patient Who Developed Ulcers in the Terminal Ileum and Recurrent Abscess-like Lesions in Multiple Organs

An Atypical Familial Mediterranean Fever Patient Who Developed Ulcers in the Terminal Ileum and Recurrent Abscess-like Lesions in Multiple Organs

Usefulness of Small Intestinal Endoscopy in a Case of Adult-onset Familial Mediterranean Fever Associated with Jejunoileitis

A Case with Familial Mediterranean Fever which Responds Well to Adalimumab Treatment

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