Successful treatment with ketoconazole of Cushing's syndrome in pregnancy

Amado, J. A.; Pesquera, C.; Gonzalez, E. M.; Otero, María Teresa Gamundi; Freijanes, J.; Álvarez, A. Carrillo

doi:10.1136/pgmj.66.773.221

Cited by 71 publications

(27 citation statements)

References 9 publications

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“…In this case, it was very difficult to control the congestive heart failure. [7,[14][15][16], whereas a number of reports recommended surgical treatment [9,17,18]. In the second trimester of pregnancy, surgical treatment has been recommended for patients with severe hypercortisolism, but conservative treatment was recommended for patients with mild hypercortisolism [9].…”

Section: Discussionmentioning

confidence: 99%

Surgical Successful Treatment of Cushing's Syndrome in a Pregnant Patient Complicated with Severe Cardiac Involvement.

et al. 1998

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Section: Discussionmentioning

confidence: 99%

Surgical Successful Treatment of Cushing's Syndrome in a Pregnant Patient Complicated with Severe Cardiac Involvement.

et al. 1998

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“…In two of the four cases ketoconazole was used during the first trimester of pregnancy. [7][8][9][10] In the rat, ketoconazole crosses the placenta and is teratogenic, and in humans it is classified as FDA category C. A recent population-based case-control study did not find a higher rate of congenital abnormalities in infants born to mothers who had received oral ketoconazole treatment during pregnancy; however, the number of exposed cases and controls was too small to allow for solid conclusions. 11 Moreover, ketoconazole has antiandrogenic effects through inhibition of aromatase activity.…”

Section: Discussionmentioning

confidence: 90%

Cabergoline treatment for recurrent Cushing’s disease during pregnancy

Nakhleh

Saiegh

Reut

et al. 2016

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ObJECTIvE: Cushing`s disease during pregnancy is associated with an increased risk for maternal and fetal complications. In recurrent Cushing`s disease following transsphenoidal surgery, and when re-operation is not feasible, medical treatment is usually considered. Cabergoline was found to be effective in reducing hypercortisolism in Cushing's disease. Evolving data concerning the safety of cabergoline use during pregnancy show no significant increase in the rate of complications during pregnancy or the postnatal period. mEThODS: We report a 29-year-old woman, gravida 0, para 0, with recurrent Cushing`s disease, three years after transsphenoidal resection of pituitary aCTh-secreting macroadenoma. Repeated mRI revealed an empty sella with a small gadolinium-enhancing lesion, suspected to be an adenoma remnant on the medial wall of the right cavernous sinus. as the patient was not willing to undergo repeat surgical intervention, treatment with cabergoline was initiated, with a gradual dose titration up to 3.5 mg/week. Clinical improvement ensued, and 4 months later, she conceived spontaneously. after discussing treatment options with the patient, cabergoline treatment at a dose of 2 mg/week was continued throughout pregnancy. RESUlTS: The patient showed complete clinical remission during pregnancy. Consecutive tests of 24-h urinary free cortisol concentration were not found to be elevated. pregnancy and delivery were uneventful except for mild hypothyroidism observed during the second trimester. at full term the patient delivered a healthy female infant, by an elective cesarean section. CONClUSION: This case report demonstrates that cabergoline may be an effective and safe therapeutic option for the treatment of Cushing's disease during pregnancy.Key words: Cabergoline, Cushing's disease, Pregnancy HORMONES 2016, 15(3):453-458 Address for correspondence: Dr. Afif Nakhleh, Endocrinology Department, Bnai Zion Medical Center, 47 Golomb St, Haifa 31048, Israel; Tel.: +972-4-8359931, E-mail: anakhleh@yahoo.com Received: 18-03-2016, Accepted: 26-05-2016 Case report CaSE REpORTA 29 year-old woman, gravida, 0 para 0, was referred to our outpatient clinic with a 3-year history of oligomenorrhea, unexplained weight gain of 20

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“…Theo btained products feature common structural motifs of biologically and pharmaceutically active compounds. [50] This method was applicable to primary alkylamines with ahydroxy or amino group in the b-o rg-position, providing five-and six-membered heterocyclic compounds.T he reaction scope included aromatic products generated from polycyclic arenes (naphthalene,p henanthrene,9 ,9-dimethylfluorene) as well as functionalized anisole derivatives containing iodo,e ster,a mide, nitrile,ortert-butyl moieties.…”

Section: Electrochemical Càha Minationmentioning

confidence: 99%

Elektrifizierung der organischen Synthese

et al. 2018

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Die direkte Nutzung von Elektrizität für die organische Synthese erlebt derzeit eine Renaissance. Von den eher syntheseorientierten Laboratorien, die auf diesem Gebiet arbeiten, werden neuartige oder althergebrachte Konzepte genutzt, um den Weg von der Nischentechnologie zu breiteren Anwendungen zu ebnen. Da nur Elektronen als Reagens genutzt werden, wird die Bildung von Abfallreagentien effizient vermieden. Darüber hinaus können stöchiometrische Reagentien regeneriert werden und ermöglichen eine elektrokatalysierte Umsetzung. Die Anwendung von elektroorganischen Transformationen ist jedoch mehr als nur die Minimierung des Abfallaufkommens; sie führt vielmehr zu inhärent sicheren Prozessen, zur Abkürzung vieler Synthesestufen, zu milderen Reaktionsbedingungen, zu alternativen Zugängen zu gewünschten Struktureinheiten sowie zur Schaffung neuer Bereiche für geistiges Eigentum (Patente). Wenn die verwendete Elektrizität aus regenerativen Ressourcen stammt, kann dieser Stromüberschuss direkt als terminales Oxidations‐ oder Reduktionsmittel eingesetzt werden, was eine äußerst nachhaltige und damit hochattraktive Technologie darstellt. Dieser Aufsatz gibt einen Überblick über die jüngsten Entwicklungen auf dem Gebiet der elektrochemischen Synthese, welche die Zukunft dieses stark aufstrebenden Gebietes beeinflussen werden.

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Successful treatment with ketoconazole of Cushing's syndrome in pregnancy

Cited by 71 publications

References 9 publications

Surgical Successful Treatment of Cushing's Syndrome in a Pregnant Patient Complicated with Severe Cardiac Involvement.

Surgical Successful Treatment of Cushing's Syndrome in a Pregnant Patient Complicated with Severe Cardiac Involvement.

Cabergoline treatment for recurrent Cushing’s disease during pregnancy

Elektrifizierung der organischen Synthese

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