Successful treatment with narrowband UVB phototherapy in prurigo pigmentosa associated with pregnancy

Clinical manifestations and treatment outcomes in prurigo pigmentosa (Nagashima disease): A systematic review of the literature

“…In some patients, PP flares were associated with hormonal changes, such as during pregnancy, menstruation, and polycystic ovary syndrome. [16][17][18][28][29][30][31][32][33] Worsening of PP during menstruation and pregnancy suggests a possible role for hormones in the disease pathogenesis; however, there is no evidence to suggest oral contraceptives or hormone replacement therapy alter the disease course. Thus, it is unclear if estrogen directly plays a role in PP pathogenesis.…”

“…37 Moreover, neutrophilic exocytosis, interface dermatitis, spongiosis with vesiculation, and dyskeratosis are histopathological features of PP that are typically not observed in CARP. 33,38 PP is also significantly more pruritic, and hyperpigmentation from PP lesions takes much longer to resolve compared with CARP lesions. 38 This systematic review had several limitations.…”

Prurigo pigmentosa and topical tetracycline treatment

“…Systemic antibiotics (doxycycline, minocycline, tetracycline), dapsone, narrowband UVB and low dose isotretinoin are used in the treatment of PP (1)(2)(3)(4)(5). We had no chance to use any systemic agents due to hepatitis C infection.…”

“…We had no chance to use any systemic agents due to hepatitis C infection. It is remarkable that PP occurred during the treatment with narrow band UVB treatment, which is one of the treatment methods in PP (4). Narrow band UVB therapy was stopped due both to the improvement of MA and a possible trigger of PP.…”

Bullous prurigo pigmentosa in a pregnant woman with hyperemesis gravidarum

“…By contrast, only two cases of prurigo pigmentosa in association with pregnancy have been reported. 4,5 Both cases developed prurigo pigmentosa 13 weeks into their pregnancies. One of the cases suffered from severe vomiting and lost 7% of bodyweight.…”