Successful twin pregnancy achieved by assisted reproductive technology in a patient with polycystic ovary syndrome with complex atypical endometrial hyperplasia treated with levonorgestrel-releasing intrauterine system

Ercan, Cihangir Mutlu; Duru, Namık Kemal; Sakıncı, Mehmet; Alanbay, İbrahim; Karaşahin, Kazım Emre; Başer, İskender

doi:10.1080/09513590903015569

Cited by 2 publications

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“…21 Some studies have indicated that the LNG-IUS should be considered as an effective alternative treatment for complex atypical hyperplasia before ART. 22 However, there has been no reported research analyzing the effects of LNG-IUS pretreatment for patients with PCOS and simple EH before IVF-ET. The aim of the present study was to analyze the effects of LNG-IUS pretreatment for simple EH in patients with PCOS undergoing gonadotropin-releasing hormone (GnRH) agonist IVF protocols.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia

et al. 2015

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“…Specifically, over the past 2 decades, high-dose progesterone therapy has become a viable alternative to hysterectomy in some patients with complex atypical hyperplasia (CAH) and well-differentiated endometrial carcinoma (WDC), and can be delivered systemically with oral progestins or locally with a progesterone-releasing intrauterine device (IUD). [1][2][3][4][5][6][7][8][9][10][11] The ability to use progesterone therapy for these early lesions is especially useful in premenopausal women who wish to preserve fertility [12][13][14][15][16] and those who are poor surgical candidates.…”

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confidence: 99%

Assessing Endometrial Hyperplasia and Carcinoma Treated With Progestin Therapy

Mentrikoski

Shah

Hanley

et al. 2012

American Journal of Clinical Pathology

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The effects of increased amounts of progesterone on the endometrium, including such features as eosinophilic cytoplasmic metaplasia, glandular atrophy, and decidualized stroma, are well-known among surgical pathologists. These changes are typically seen as secondary effects of pregnancy or exogenous hormone therapy for birth control purposes or abnormal bleeding. Treatment with progesterone has become a viable alternative to hysterectomy in some patients with complex atypical hyperplasia (CAH) and well-differentiated endometrial carcinoma (WDC), especially those who are poor surgical candidates or those wishing to preserve fertility. To date, only 1 study has specifically examined the effects of progestin therapy on patients with a previous diagnosis of CAH or WDC. That study proposed a classification scheme for the assessment of treated CAH and WDC. The authors concluded that after 6 months of treatment, endometrial biopsy findings of persistent cytologic atypia and architectural abnormalities were associated with treatment failure. This current study aims to assess the previously proposed criteria in a cohort of 30 patients (18 with a diagnosis of CAH and 12 with a diagnosis of WDC), and determine the usefulness of these criteria in clinical practice. Our study confirms that cytologic atypia after 6 months of therapy is strongly associated with treatment failure, and should be an indication to pursue definitive surgical treatment in these patients.

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Successful twin pregnancy achieved by assisted reproductive technology in a patient with polycystic ovary syndrome with complex atypical endometrial hyperplasia treated with levonorgestrel-releasing intrauterine system

Cited by 2 publications

References 0 publications

Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia

Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia

Assessing Endometrial Hyperplasia and Carcinoma Treated With Progestin Therapy

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