2019
DOI: 10.1017/s1047951119001902
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Successful use of oral prostaglandin E1 derivative for maintaining ductus-dependent systemic circulation in a neonate with trisomy 18

Abstract: A Japanese female infant with trisomy 18 was diagnosed with hypoplastic left heart syndrome variant. She was administered oral prostaglandin E1 every 6 hours through a feeding tube as an alternative drug for lipo-prostaglandin E1. Oral prostaglandin E1 was effective for maintenance of the ductus arteriosus and may serve as a palliative treatment approach.

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Cited by 2 publications
(2 citation statements)
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“…It is possible that the use of PGE1 analogs with oral bioavailability may overcome this practical problem. For instance, an oral PGE1 has been used instead of lipo‐PGE1 to maintain duct‐dependent systemic circulation in a neonate with trisomy‐18 38 . However, further research is required to explore whether an oral PGE1 analog may have effects similar to lipo‐PGE1 on patients undergoing PD.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is possible that the use of PGE1 analogs with oral bioavailability may overcome this practical problem. For instance, an oral PGE1 has been used instead of lipo‐PGE1 to maintain duct‐dependent systemic circulation in a neonate with trisomy‐18 38 . However, further research is required to explore whether an oral PGE1 analog may have effects similar to lipo‐PGE1 on patients undergoing PD.…”
Section: Discussionmentioning
confidence: 99%
“…with trisomy-18. 38 However, further research is required to explore whether an oral PGE1 analog may have effects similar to lipo-PGE1 on patients undergoing PD.…”
Section: Ta B L Ementioning
confidence: 99%