Social and healthcare improvements have prolonged individuals' lifespan worldwide, while they have resulted in an increased number of patients with end-stage renal disease (ESRD). 1 Peritoneal dialysis (PD) is extensively applied in the treatment of ESRD, with comparable outcomes to hemodialysis, including preservation of residual renal function, 2 being cost-effective, and higher quality of life. 3 In recent years, PD utilization has greatly attracted clinicians' attention in China, and over 250,000 patients have received PD according to the statistics reported in 2012. 4 However, peritoneal transport function gradually diminishes with the extended use of PD, and can eventually lead to ultrafiltration failure. [5][6][7] The dialysate/plasma creatinine ratio (D/Pcr) and the mass transfer area coefficient (MTAC) for urea (MTAC-urea) and creatinine (MTAC-creatinine) are commonly used indicators to assess peritoneal transport of small molecular solutes. 8 A specific correlation was reported between D/Pcr and MTAC-creatinine, and a change in MTAC can influence the effective peritoneal surface area. 9 In addition to the transport of creatinine and other small molecular