“…The most important associated risk factors were age, 6 body massindex, 6,16,19 parity, 11 total vaginal length, 8,12,15,18 larger genital hiatus, 7,12,15,18 pelvic floor muscle activity, 6 previous surgeries, 15,16 previous hysterectomy 11,16 and advanced POP staging. 7,17 Eleven studies did not describe the use of vaginal estrogen cream during the pessary use, 6,7,10,11,15,19,26,30,32,33,35 and 10 have described its use differently 8,12,[16][17][18]27,28,29,31,34 of these studies, two of them have only indicated for women with vaginal atrophy identified at the gynecological examination. 28,29 Two studies have counseled patients that if vaginal ulceration or excoriation occurred, women should withdraw the pessary and wait for 2 weeks to maintain vaginal estrogen.…”