Successful use of ultrasound elastography in the preliminary intermediate evaluation of therapeutic response in patients with Hodgkin’s lymphoma

Objective: to evaluate the possibilities of ultrasound elastography for differentiation of reactive and lymphomatous superficial lymph nodes (LN).Materials and methods. The prospective study included 138 patients with enlarged superficial LN. Based on a previous histological examination, patients were divided into two groups: 1st group (n = 108) – patients with non-Hodgkin’s lymphomas and Hodgkin’s lymphoma; 2nd (n = 30) – patients with reactive (inflammatory) changes in superficial LN. All patients underwent ultrasound elastography of the enlarged LN using ARFI technology.Results. According to the results of ultrasound elastography, the average, minimum, and maximum shear wave velocities for enlarged LN in lymphoma (1st group) were 2.616 ± 0.684; 1.980 ± 0.557 and 3.351 ± 0.987 m / s, respectively; for LN with reactive changes (2nd group) – 1.704 ± 0.223; 1.414 ± 0.209 and 2.027 ± 0.261 m / s, respectively. Thus, the average, minimum, and maximum values of shear wave velocities significantly different between the groups (p ˂0.001). The cut off values of the average shear wave velocity in the differential diagnosis of lymphoma and hyperplasia are determined at the level of 2.05 m / s, with a sensitivity of 88.5 %, specificity of 100 %, and AUC of 0.942 (p ˂0.001).Conclusion. Ultrasound elastography demonstrated statistically significant differences in shear wave velocity in the enlarged superficial LN in lymphoma and in inflammatory processes that can be used as a preliminary non-invasive differential diagnosis of enlarged superficial LN in these conditions.

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Evaluation of the possibilities of shear wave elastography for differentiation of lymphomatous and reactive changes of superficial lymph nodes

Ковалева

Данзанова

Синюкова

et al. 2020

Onkogematologiâ

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Successful experience in the use of ultrasound elastography in the differentiating of lymphomatous and metastatic superficial lymphadenopathy

et al. 2020

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The objective: to evaluate the possibilities of ARFI technology (Acoustic Radiation Force Impulse), including Virtual Touch™ Tissue Imaging (VTI) and Virtual Touch™ Tissue Quantification (VTQ) for differentiation of lymphomatous and metastatic superficial lymphadenopathy.Materials and methods. The prospective study included 138 patients with enlarged superficial lymph nodes (LN). Based on a previous histological examination, patients were divided into two groups: 1st group (n = 108) – patients with non-Hodgkin’s lymphomas and Hodgkin’s lymphoma; 2nd group (n = 30) – patients with metastasis of solid tumors in superficial LN. All patients underwent ultrasound elastography of the enlarged LN using ARFI technology. In VTI study the Area Ratio parameter was evaluated, and the minimum and average values of the shear wave velocity were estimated in VTQ study.Results. According to the results of VTI study the Area Ratio parameter for enlarged LN in lymphoma (1st group) and for metastatic lymphadenopathy (2 nd group) were 1.031 ± 0.197 and 0.851 ± 0.15, respectively (p = 0.000009). The cut off value of the Area Ratio parameter was 0.901 with sensitivity, specificity and accuracy 80.6, 70.0 and 78.8 %, respectively. Minimum values of shear wave velocities for 1st and 2 nd groups were 1.980 ± 0.557 and 2.214 ± 0.367 m/s, respectively (p = 0.032). The cut off values of the average shear wave velocity in the differentiating of lymphomatous and metastatic lymphadenopathy are determined at the level of 2.00 m/s, with sensitivity of 70.0 %, specificity of 59.3 %, and accuracy of 61.6 %.Conclusion. Ultrasound elastography with ARFI technology demonstrated statistically significant differences in the Area Ratio parameter and in the minimum shear wave velocity in the enlarged superficial LN in lymphoma and with metastasis that can be used as a preliminary non-invasive differential diagnosis of enlarged superficial LN in these conditions. Moreover, the Area Ratio parameter has a statistically more significant effect on differentiating of lymphomatous and metastatic lymphadenopathy.

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Ultrasound patterns of metastases from papillary thyroid cancer in soft tissues of the neck

Parshin

Веселова

Bespalov

et al. 2022

Issled. prakt. med. (Print)

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Purpose of the study. To assess ultrasound features and patterns of features for metastatic papillary thyroid cancer (PTC) in soft tissues of the neck.Materials and methods. The study included 335 histologically confirmed metastases and 102 benign lymph nodes (LN). Statistical processing was carried out in the SPSS program. The reliability between the groups was assessed by criterion t with a significance level of p < 0.05. The informative value of ultrasound signs and patterns of signs, and the probability of the presence of metastasis using binary logistic regression are calculated.Results. The 14 criteria for metastasis have been studied. There are 33 signs, i.e. types of criteria. During the statistical analysis, six most informative criteria were established: calcifications, contours, shape, depth-to-width ratio in the transverse scanning plane, state (differentiation) of the cortical and cerebral layers, echostructure. To create complexes (patterns) of ultrasonic signs, a combination of these signs was used among themselves, and five patterns were established. The first pattern, including the depth-to-width ratio in the transverse scanning plane and the echo structure, has a sensitivity (Se) of 97 %, diagnostic accuracy (Ac) of 96.5 %, area under the curve (AUC) of 96 %, the probability ranges from 95 to 99 %. The Se of the second pattern, including the ratio of depth to width in the transverse scanning plane, echostructure and shape, was 97.2 %, Ac – 96.8 %, AUC – 97.3 %, probability – 95–100 %. The third pattern, including the ratio of depth to width in the transverse scanning plane, nature, shape and contours, and the fourth pattern, including the following criteria, the ratio of depth to width in the transverse scanning plane, echostructure, shape, contours and differentiation into cortical and cerebral layers, have Se 96.9 %, Ac – 97.1 %, AUC – 98.7 %, probability – 88–100 %. The fifth pattern, including the ratio of depth to width in the transverse scanning plane, echostructure, shape; contours; state (differentiation) of the cortical and cerebral layers; calcinates, has Se – 99.6 %, Ac – 99.5 %, AUC – 99.9 %, probability – 94–100 %.Conclusion. Five patterns of metastatic involvement of lymph nodes in PTC were found. The informative value of US increased from the first to the fifth pattern achieving a Se of 99.6 %, Ac of 99.5 %, AUC of 99.9 %. The probability ranged from 94 % to 100 %.

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Successful use of ultrasound elastography in the preliminary intermediate evaluation of therapeutic response in patients with Hodgkin’s lymphoma

Cited by 8 publications

References 16 publications

Evaluation of the possibilities of shear wave elastography for differentiation of lymphomatous and reactive changes of superficial lymph nodes

Evaluation of the possibilities of shear wave elastography for differentiation of lymphomatous and reactive changes of superficial lymph nodes

Successful experience in the use of ultrasound elastography in the differentiating of lymphomatous and metastatic superficial lymphadenopathy

Ultrasound patterns of metastases from papillary thyroid cancer in soft tissues of the neck

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