Successful Use of Vacuum-Assisted Closure Therapy for Leg Ulcers Caused by Occluding Vasculopathy and Inflammatory Vascular Diseases – A Case Series

Zutt, Markus; Haas, E; Krüger, Ullrich; Distler, Meike; Neumann, Christine

doi:10.1159/000100882

Cited by 17 publications

(12 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The extensive studies on the established use of the VAC technique in the wound-healing phase of granulation have resulted in guidelines that recommend VAC therapy in acute and chronic wounds [7,8,9,10,11,12], burns [13], diabetic ulcers [14, 15] as well as open foot wounds [16], vasculitis- or occluding vasculopathy-induced ulcers [17]. However, there have been very few reports on the postoperative application of VAC therapy [18, 19].…”

Section: Discussionmentioning

confidence: 99%

Vacuum Assisted Closure Device Improves the Take of Mesh Grafts in Chronic Leg Ulcer Patients

et al. 2008

View full text Add to dashboard Cite

Background: Vacuum assisted closure (VAC) is established in the management of acute and chronic wounds. In recent years, few data have been published concerning VAC therapy after skin graft transplantation. Objectives: The aim of this study was to determine whether postoperative VAC helps assist closure of mesh grafts in chronic leg ulcer patients. Patients/Methods: We report a consecutive case series of 54 patients with chronic leg ulcers who received a total of 74 mesh grafts. A postoperative VAC therapy was performed in 28 mesh grafts, and 46 mesh grafts were treated with standard gauze therapy. Results: In the VAC group, 92.9% of grafts showed complete healing, compared to 67.4% in the control group without postoperative VAC therapy. Differential analysis revealed a negative correlation of the take rate in patients over 70 years of age or in patients suffering from diabetes mellitus or dermatoliposclerosis. Particularly patients with diabetes mellitus and of greater age exhibited improved take rates, both 100%, in the VAC group compared to 50 and 62%, respectively. Conclusion: The results of our retrospective study demonstrate for the first time the significant benefit of VAC therapy after skin grafting in chronic leg ulcer patients as evaluated in a clinical trial.

show abstract

Section: Discussionmentioning

confidence: 99%

Vacuum Assisted Closure Device Improves the Take of Mesh Grafts in Chronic Leg Ulcer Patients

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Thus, the utility of such tissue material is primarily limited to histological studies. Vasculopathy represents a major factor that complicates cutaneous wound healing (4,5). The objective of this study was to develop an approach to specifically laser capture blood vessels from standard 3-mm human wound biopsies such that the captured blood vessel tissue element would lend itself to genomic screening and verification of candidate genes, using quantitative PCR.…”

mentioning

confidence: 99%

Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue

Roy

Patel

Khanna

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

105

131

View full text Add to dashboard Cite

Chronic wounds represent a substantial public health problem. The development of tools that would enable sophisticated scrutiny of clinical wound tissue material is highly desirable. This work presents evidence enabling rapid specific identification and laser capture of blood vessels from human tissue in a manner which lends itself to successful high-density (U133A) microarray analysis. Such screening of transcriptome followed by real-time PCR and immunohistochemical verification of candidate genes and their corresponding products were performed by using 3 mm biopsies. Of the 18,400 transcripts and variants screened, a focused set of 53 up-regulated and 24 down-regulated genes were noted in woundderived blood vessels compared with blood vessels from intact human skin. The mean abundance of periostin in wound-site blood vessels was 96-fold higher. Periostin is known to be induced in response to vascular injury and its expression is associated with smooth muscle cell differentiation in vitro and promotes cell migration. Forty-fold higher expression of heparan sulfate 6-Oendosulfatase1 (Sulf1) was noted in wound-site vessels. Sulf1 has been recently recognized to be anti-angiogenic. During embryonic vasculogenesis, CD24 expression is down-regulated in human embryonic stem cells. Wound-site vessels had lower CD24 expression. The findings of this work provide a unique opportunity to appreciate the striking contrast in the transcriptome composition in blood vessels collected from the intact skin and from the wound-edge tissue. Sets of genes with known vascular functions but never connected to wound healing were identified to be differentially expressed in wound-derived blood vessels paving the way for innovative clinically relevant hypotheses.angiogenesis ͉ microarray ͉ wound healing

show abstract

“…It has also been used to heal wounds by secondary intention or as a bolster type dressing to improve skin graft take, with Ghersi et al (21) demonstrating healing of PG wound by secondary intention specifically. The relevance of this modality to chronic wound management must not be understated because it not only provides an effective barrier to secondary infection, but also requires less frequent dressing changes and improves the local microcirculation, resulting in healthy granulation tissue formation (22).…”

Section: Figure 4) Left Hand Lesion Showing Healthy Granulation Tissumentioning

confidence: 99%

Pyoderma gangrenosum: A case report of bilateral dorsal hand lesions and literature review of management

Mowlds¹,

Kim²,

Murphy³

et al. 2013

CAN J PLAST SURG

View full text Add to dashboard Cite

Successful Use of Vacuum-Assisted Closure Therapy for Leg Ulcers Caused by Occluding Vasculopathy and Inflammatory Vascular Diseases – A Case Series

Cited by 17 publications

References 9 publications

Vacuum Assisted Closure Device Improves the Take of Mesh Grafts in Chronic Leg Ulcer Patients

Vacuum Assisted Closure Device Improves the Take of Mesh Grafts in Chronic Leg Ulcer Patients

Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue

Pyoderma gangrenosum: A case report of bilateral dorsal hand lesions and literature review of management

Contact Info

Product

Resources

About