2012
DOI: 10.1155/2012/374098
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Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments

Abstract: The Stroke Therapy Academic Industry Roundtable (STAIR) provided initial (in 1999) and updated (in 2009) recommendations with the goal of improving preclinical stroke therapy assessment and to increase the translational potential of experimental stroke treatments. It is important for preclinical stroke researchers to frequently consider and revisit these concepts, especially since promising experimental stroke treatments continue to fail in human clinical trials. Therefore, this paper will focus on considerati… Show more

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Cited by 40 publications
(49 citation statements)
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“…9 We have found that sustained, low-dose treatment with L-655,708 progressively reduced volumes of necrotic core and perilesional tissue and improved fine motor reaching ability. Furthermore, behavioral improvement was inversely related to the necrotic, perilesional, and total stroke volume.…”
Section: ) (A)mentioning
confidence: 80%
“…9 We have found that sustained, low-dose treatment with L-655,708 progressively reduced volumes of necrotic core and perilesional tissue and improved fine motor reaching ability. Furthermore, behavioral improvement was inversely related to the necrotic, perilesional, and total stroke volume.…”
Section: ) (A)mentioning
confidence: 80%
“…This is consistent with the recommendations provided by the Stroke Therapy Academic Industry Roundtable (STAIR) that is aimed at improving preclinical studies to increase the translational potential of experimental stroke treatments. 94 This is crucial, since promising treatments validated in preclinical models usually fail in clinical trials. Although the validity of the STAIR's recommendations has not been always confirmed, [95][96][97] they represent a useful guide for researchers planning preclinical stroke studies by providing directions on the selection and execution of the animal model, the fundamentals of good scientific inquiry, the choice and measurement of outcomes, and the drug/treatment administration, including the route and time-window.…”
Section: Discussionmentioning
confidence: 99%
“…23 These translational failures are multifactorial, including limitations of individual animal models to reflect the complexity of drug targets for preventing reperfusion injury. 24 The outcome model of cardiac arrest used in the present study attempts to address some limitations recognized in previous animal models. 13 Thermoregulation is also an appealing translational target of neuroprotectant agents because reperfusion injury is temperature dependent across species.…”
Section: Discussionmentioning
confidence: 99%