Successfully Treated Case of Pemphigoid Gestationis with Post-Partum Intravenous and Oral Steroids

Kumar, Sameer; Biswas, Manash; Rajagopal, Rama; Datta, Sujata; Narayan, Brijesh

doi:10.1007/s13224-013-0408-0

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…In the postpartum period, topical and oral glucocorticoids continue to be the treatments of choice. However, other treatments that have been tried in isolated cases include tetracyclines with or without nicotinamide, cyclophosphamide, plasmapheresis, intravenous immunoglobulin, rituximab, and goserelin .…”

Section: Answermentioning

confidence: 99%

Pemphigoid gestationis

Papapanagiotou

Tsagouri

Liakou

et al. 2018

Clinical Case Reports

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Key Clinical MessagePemphigoid gestationis is a rare autoimmune skin disorder emerging exclusively during pregnancy. Topical and oral glucocorticoids as well as oral antihistamines are the standard medications administered during pregnancy, aiming to relieve pruritus and to suppress extensive blister formation. Obstetricians should be able to recognize and treat this rare clinical condition accordingly.

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Section: Answermentioning

confidence: 99%

Pemphigoid gestationis

Papapanagiotou

Tsagouri

Liakou

et al. 2018

Clinical Case Reports

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Gestational Pemphigoid—From Molecular Mechanisms to Clinical Outcomes: A Case Report and Review of Literature

Cristescu,

Tutunaru,

Panaitescu

et al. 2024

Life

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Gestational pemphigoid is a rare, autoimmune, subepidermal bullous disease with an incidence of 1 in 50,000 pregnancies, displaying itself through pruritic erythema and urticarial papules and plaques that evolve into tense bullae. Histopathological findings consist of subepidermal vesicles with perivascular eosinophils and lymphocytes, and direct immunofluorescence reveals C3 complement and, more rarely, IgG in a linear band along the basement membrane. The course is usually self-limiting within 6 months after delivery but, later, can be triggered by subsequent pregnancies, menstruation, or treatment with oral contraceptives. The newborn can be affected due to the transplacental passage of the maternal immunoglobulins, but, usually, less than 10% of newborns will develop lesions similar to pemphigoid gestationis. The diagnosis and management pose a difficult challenge and should be guided by the severity of the disease. We, therefore, provide a short literature review and discussion plus a case from our clinic, with a typical presentation but a delayed diagnosis and an undulating evolution, with severe manifestations and particularly difficult management due to unexpected complications.

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Successfully Treated Case of Pemphigoid Gestationis with Post-Partum Intravenous and Oral Steroids

Cited by 2 publications

References 9 publications

Pemphigoid gestationis

Pemphigoid gestationis

Gestational Pemphigoid—From Molecular Mechanisms to Clinical Outcomes: A Case Report and Review of Literature

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