Succinic acid production from glycerol by Actinobacillus succinogenes using dimethylsulfoxide as electron acceptor

Carvalho, Margarida; Matos, Mariana; Roca, Christophe; Reis, Maria A.M.

doi:10.1016/j.nbt.2013.06.006

Cited by 63 publications

(51 citation statements)

References 19 publications

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“…33 Under anaerobic conditions, Carvalho et al studied the utilization of dimethylsulfoxide (DMSO) at concentrations between 1-4 v/v % as electron acceptor. 34 Th eir results demonstrated that DMSO acted as a biocatalyst to improve the glycerol utilization effi ciency and the conversion to SA. Maximum conversion (80%) was observed at 1.4% DMSO in 4 g L -1 glycerol.…”

Section: Poly-alcoholsmentioning

confidence: 99%

A review of progress in (bio)catalytic routes from/to renewable succinic acid

Mazière

Prinsen

García

et al. 2017

Biofuels Bioprod Bioref

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In the last decade, succinic acid has become a key platform chemical in the bio‐based industry. It is one of the few renewable chemicals that have proven to be competitive with the fossil‐derived production. Still, improvements can be made in terms of sustainability, especially in the usage of alternative carbon sources for advanced life cycles. Numerous catalytic routes have been developed for the conversion of bio‐succinate to a wide range of chemical compounds and bio‐based polymers. However, most of them have been demonstrated from pure isolated succinic acid, but the isolation and purification of succinic acid from fermentation broths is no mean task and requires a considerable amount of energy. Therefore, catalytic routes in aqueous phase have also been studied intensively to by‐pass isolation and purification steps. This review describes the recent developments published in this research field. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd

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Section: Poly-alcoholsmentioning

confidence: 99%

A review of progress in (bio)catalytic routes from/to renewable succinic acid

Mazière

Prinsen

García

et al. 2017

Biofuels Bioprod Bioref

View full text Add to dashboard Cite

show abstract

“…In recent years, the interest in succinic acid production is growing because of the possibility to use it in the production of polymers and biodegradable plastics, surfactants, detergents, electrolytic coatings, and pharmaceutical active agents [9,10]. Generally, the technology of succinic acid biosynthesis ends at the stage of obtaining a post-culture liquid called post-fermentation broth, in which succinic acid produced by bacteria is dissolved [11][12][13][14]. Unfortunately, due to complex fermentation process, the main product is contaminated with various metabolites, especially with organic acids: acetic, formic, and others at low concentrations.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Total Volume Membrane Charge Density through Mathematical Modeling for Separation of Succinic Acid Aqueous Solutions on Ceramic Nanofiltration Membrane

et al. 2019

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Nanofiltration of aqueous solutions of succinic acid with the addition of sodium hydroxide or magnesium hydroxycarbonate has been investigated experimentally and modeled with the comprehensively described Donnan-Steric partitioning model. The experimental retentions of acid at the same pH varied between 16% and 78%, while the estimated total volume membrane charge densities were in the range of −35.73 and +875.69 mol/m 3 . This work presents a novel insight into the modeling of nanofiltration and investigates the relations between the estimated total volume membrane charge densities, ionic strength, and component concentration on the performance of ceramic membrane. In addition, this study takes into consideration other parameters such as pH regulation and viscosities of solutions.

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“…From an industrial perspective, there has been great effort to obtain high productivity strains based on bioprospection and metabolic engineering (Table ). Wild strains include Actinobacillus succinogenes , Anaerobiospirillum succiniciproducens, and Mannheimia succiniciproducens, while genetic engineering efforts have mainly worked with Escherichia coli ( E. coli ) and Saccharomyces cerevisiae . Escherichia coli has been studied the most due to the existing knowledge on heterologous expression and deletion …”

Section: Introductionmentioning

confidence: 99%

Effects of metabolic engineering on downstream processing operational cost and energy consumption: the case of Escherichia coli's glycerol conversion to succinic acid

Rangel

Valera

Gómez

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND: Succinic acid production has been studied from a metabolic engineering or a downstream processing perspective, separately. The concentration of succinic acid and other by-products obtained after the strain design influences the production cost during the recovery and purification stage. A metabolic engineering-downstream coupling evaluation is important when selecting the metabolic targets for the strain design. In this in silico study, the metabolic engineering of an Escherichia coli strain to produce succinic acid using glycerol as a carbon source in the downstream process was evaluated in terms of operational cost and energy consumption. (0.3068, 0.0576, 0.1089 h -1 ) and succinate productivity (2.7534, 6.0772, 5.5661 mmol g -1 DW h -1 ), respectively. The results showed that the succinic acid productivity constituted a central parameter when selecting the appropriate gene targets for deletion, despite the presence of organic acids in the downstream process and the biomass growth rate. RESULTS: Three strain scenarios were selected using a bi-level linear optimization problem solved by Mixed Integer Linear Programing, and simulated in a transient fashion with dynamic flux balance analysis considering both biomass growth rate CONCLUSION: A metabolism-downstream coupled model shows that the bioproduct productivity and fermentation timeare key points when considering the operational cost and energy consumption involved in the engineering of strains for industrial-scale production.Metabolic engineering targets were obtained using OptKnock, which is a bi-level linear optimization problem solved by MILP. 33

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Succinic acid production from glycerol by Actinobacillus succinogenes using dimethylsulfoxide as electron acceptor

Cited by 63 publications

References 19 publications

A review of progress in (bio)catalytic routes from/to renewable succinic acid

A review of progress in (bio)catalytic routes from/to renewable succinic acid

Assessment of the Total Volume Membrane Charge Density through Mathematical Modeling for Separation of Succinic Acid Aqueous Solutions on Ceramic Nanofiltration Membrane

Effects of metabolic engineering on downstream processing operational cost and energy consumption: the case of Escherichia coli's glycerol conversion to succinic acid

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