Succinylcholine Danger in the Burned Patient

The effects of precurarization with a protective dose of d-tubocurarine in the conscious patient

“…This results in minimal asthenia of the small, discriminative muscles of the face, with almost no significant effect on the limbs and the respiratory musclesY 8 The rationale for precurarization in the conscious state, rather than postcurarization in a patient already asleep, rests on two bases. Firstly, precurarization with a protective dose is mandatory in some clinical cases, namely in patients with a full stomach and in subiects with penetrating eye iniuries, in which postcurarization carries the definite hazards of a delayed onset of full paralysis and late endotraeheal intubation.…”

Comparative Study of Succinylcholine with Different Doses of Rocuronium Bromide for Tracheal Intubation during General Anaesthesia

“…[1,2,3] Its rapid onset of effect and ultrashort duration of action permitted rapid endotracheal intubation. [4] But all did not go well for succinylcholine when its adverse effects started surfacing especially fasciculations [5], hyperkalemia [6,7], post-operative muscle pains [8], rise in intragastric, intracranial and intraocular pressure. [9] The aim of research on neuromuscular drugs was to have a nondepolarising muscle relaxant (NDMR), which is like succinylcholine but without its side effects.…”

Suxamethonium-Induced Hyperkalaemia in Patients With Severe Intra-Abdominal Infections

“…A dangerous increase in serum potassium concentrations after the administration of suxamethonium has been reported in an increasing number of clinical conditions including burns (Tolmie, Joyce and Mitchell, 1967), massive muscle trauma (Birch et al, 1969;Mazze, Escue and Houston, 1969), tetanus (Roth and Wuthrich, 1969), neuromuscular disease (Cooperman, 1970) and uraemia (Roth and Wuthrich, 1969;Walton and Farman, 1973). Several of the reported patients suffered cardiac arrest within 5 min after the administration of suxamethonium.…”