Succinylsulfathiazole Crystal Forms III: Crystal Growth Studies

Physico‐chemical and formulation‐induced veterinary drug‐product bioinequivalencies

“…Many formulators have taken steps to prevent polymorphic transition during the products' shelf-life and thus decrease the chance of batch to batch variability as follows: (i) By using only the most stable polymorphic species in formulations (Macek, 1965; Pearson & Varney, 1969;Frederick, 1961 Moustafa et al, 1975).…”

“…These interconversionse.g. dehydration when stored in low humidity conditions or at elevated temperatures, or hydration when formulated as an aqueous suspension (Macek, 1965;Pearson & Varney, 1969;Ebian e t al., 1975;Moustafa et al, 1975) -can again lead to batch to batch differences in the performance of drug formulations.…”