Sucrase-isomaltase is an independent prognostic marker for colorectal carcinoma

Abstract

These results indicate that SI is a prognostic marker for CRC that is independent of stage-related variables in patients who have undergone potentially curative resections.

Association between sucrase-isomaltase and p53 expression in colorectal cancer

“…We have previously shown that expression of SI in primary colorectal carcinomas is associated with a nearly twofold increase in the recurrence of that cancer at a distant site (19). In the present work we assessed first whether the expression of the phenotypic markers SI, DF3, or galectin 3 was significantly associated with standard clinical or pathologic variables or with each other in a set of 165 patients who underwent surgery between 1965 and 1977.…”

“…2). When a multivariate Cox proportional hazards analysis was performed, neither DF3 nor galectin 3 were significant covariates when included in the final model that retained SI (19). The sample size and follow-up duration were adequate to rule out a 50% difference in survival with at least 80% power and 5% type I error for a two-sided hypothesis test of equal hazard ratios for the marker being present versus absent.…”

“…The first group comprised 183 stage I-III patients who underwent surgery at the Deaconess Hospital with curative intent between 1965 and 1977 and had a median follow-up of 9 years, as described by Jessup et al (19). The expression of SI, of DF3, and of galectin 3 were assessed by IHC, and each was tested for association with both clinicopathologic variables and with cancer-specific survival.…”

“…A specific polyclonal rabbit antibody, adapted to an automated processor, was used to detect SI expression as previously described using an avidin-biotin technique (19). DF3 antigen expression was assessed using a murine monoclonal antibody and peroxidase-antiperoxidase technique as described by Andrews et al (18).…”

“…DF3, a Muc 1 mucin (17), the third candidate marker, is not expressed in normal or moderately dysplastic bowel epithelium but is expressed in adenomatous polyps that contain either carcinoma in situ or invasive cancer (18). Expression of SI was an independent prognostic factor of worse prognosis in a multivariate analysis that included stage and histologic covariates in 183 patients who underwent surgery at New England Deaconess Hospital between 1965 and 1977 (19). The associations of the other prognostic markers with either outcome or the genetic alterations that underpin neoplastic transformation are not known and are the subject of this report.…”