Sucrose acetate isobutyrate based nanovesicles: A promising platform for drug delivery and bioavailability enhancement

Elshafeey, Ahmed Hassen; Zayed, Reham; Shukr, Marwa Hassan; Elsayed, Ibrahim

doi:10.1016/j.jddst.2020.101806

Cited by 3 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To overcome these limitations and to mitigate the unfavorable pharmacokinetic profile, different nanoparticle-based drug delivery approaches are being developed to improve SBN bioavailability [15,16]. Systems based on polymeric nanoparticles demonstrate long-term stability, improved effectiveness, non-toxicity, and targeted drug release in comparison with traditional carriers [17][18][19][20]. In addition, when the particle size is under 200 nm, an increased drug accumulation in tumor cells is observed due to enhanced permeability [21].…”

Section: Introductionmentioning

confidence: 99%

PEG-Modified tert-Octylcalix[8]arenes as Drug Delivery Nanocarriers of Silibinin

et al. 2021

View full text Add to dashboard Cite

The hepatoprotective properties of silibinin, as well its therapeutic potential as an anticancer and chemo-preventive agent, have failed to progress towards clinical development and commercialization due to this material’s unfavorable pharmacokinetics and physicochemical properties, low aqueous solubility, and chemical instability. The present contribution is focused on the feasibility of using PEGylated calixarene, in particular polyoxyethylene-derivatized tert-octylcalix[8]arene, to prepare various platforms for the delivery of silibinin, such as inclusion complexes and supramolecular aggregates thereof. The inclusion complex is characterized by various instrumental methods. At concentrations exceeding the critical micellization concentration of PEGylated calixarene, the tremendous solubility increment of silibinin is attributed to the additional solubilization and hydrophobic non-covalent interactions of the drug with supramolecular aggregates. PEG-modified tert-octylcalix[8]arenes, used as drug delivery carriers for silibinin, were additionally investigated for cytotoxicity against human tumor cell lines.

show abstract