Sucrose compared with artificial sweeteners: a clinical intervention study of effects on energy intake, appetite, and energy expenditure after 10 wk of supplementation in overweight subjects

Sørensen, Louise Bergmann; Vasilaras, Tatjana H; Astrup, Arne; Raben, Anne

doi:10.3945/ajcn.113.081554

Cited by 40 publications

(56 citation statements)

References 34 publications

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“…Overall, these studies have reported neutral effects or modest benefits of LCS on energy intake [43, 44] and weight [21, 22, 27, 28, 30, 31, 45–47]. For example, de Ruyter et al [21] reported less weight gain in children assigned to replace their daily sugar-sweetened beverage with a flavor-matched non-caloric beverage in an 18-month intervention.…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…Reductions in body weight following replacement of sugar-sweetened beverages with LCS, particularly when studied in the context of weight loss (see Section 2.7. ), are convincing; yet, many of these studies lack a true control [21, 22, 30, 44, 45, 47–49]: that is, plain water, unsweetened seltzer, and/or calorie-matched foods without sweetness.…”

Section: Methodological Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research

Sylvetsky

Blau

Rother

2016

Rev Endocr Metab Disord

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Consumption of foods, beverages, and packets containing low-calorie sweeteners (LCS) has increased markedly across gender, age, race/ethnicity, weight status, and socioeconomic subgroups. However, well-controlled intervention studies rigorously evaluating the health effects of LCS in humans are limited. One of the key questions is whether LCS are indeed a beneficial strategy for weight management and prevention of obesity. The current review discusses several methodological considerations in the design and interpretation of these studies. Specifically, we focus on the selection of study participants, inclusion of an appropriate control, importance of considering habitual LCS exposure, selection of specific LCS, dose and route of LCS administration, choice of study outcomes, and the context and generalizability of the study findings. These critical considerations will guide the design of future studies and thus assist in understanding the health effects of LCS.

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Section: Methodological Considerationsmentioning

confidence: 99%

Section: Methodological Considerationsmentioning

confidence: 99%

Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research

Sylvetsky

Blau

Rother

2016

Rev Endocr Metab Disord

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“…~ 1 liter/day) to their diets for periods of 6 – 10 weeks, outcomes are significantly worse when the beverages are sugar-sweetened compared to artificially-sweetened [e.g. [18]. However, data from other interventional studies indicate that weight loss outcomes are similar when sugar-sweetened beverages were replaced by either water or artificially sweetened beverages [19], and that consuming artificially-sweetened beverages in place of sugar-sweetened beverages did not lead to greater reductions in total sugar intake compared to consuming water [20].…”

Section: But What About Weight?mentioning

confidence: 99%

Not-so-healthy sugar substitutes?

Swithers

2016

Current Opinion in Behavioral Sciences

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Replacing sugar-sweetened beverages with diet soft drinks containing sugar substitutes that provide few or no calories has been suggested as one strategy for promoting improved public health outcomes. However, current scientific evidence indicates that routine consumption of beverages with non-nutritive sweeteners not only fails to prevent disease, but is associated with increases in risks for the same health outcomes associated with sugar-sweetened beverages, including type 2 diabetes, cardiovascular disease, hypertension and stroke. Results from pre-clinical studies have provided plausible biological mechanisms that could promote these counterintuitive negative health effects of artificial sweeteners. Taken together, scientific studies currently indicate that public health will be improved by reducing intake of all sweeteners, both caloric and non-caloric.

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“…Recently, the WHO have suggested that their 2015 guidelines on sugar intake should be used to develop a strategy for reformulation of processed foods, such as those rich in free sugars [6]. However, it should be recognized that the replacement of sugar-sweetened products with sugar-reduced or artificially sweetened alternatives may be associated with compensatory responses in EI and/or energy expenditure (EE), which in turn may only lead to modest weight loss [13–15]. Yet there are very limited data on the efficacy of using sugar-reformulated products on body weight, energy balance (EB) dynamics and the possibility of energy compensation [16].…”

Section: Introductionmentioning

confidence: 99%

Energy compensation following consumption of sugar-reduced products: a randomized controlled trial

2015

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PurposeConsumption of sugar-reformulated products (commercially available foods and beverages that have been reduced in sugar content through reformulation) is a potential strategy for lowering sugar intake at a population level. The impact of sugar-reformulated products on body weight, energy balance (EB) dynamics and cardiovascular disease risk indicators has yet to be established. The REFORMulated foods (REFORM) study examined the impact of an 8-week sugar-reformulated product exchange on body weight, EB dynamics, blood pressure, arterial stiffness, glycemia and lipemia.MethodsA randomized, controlled, double-blind, crossover dietary intervention study was performed with fifty healthy normal to overweight men and women (age 32.0 ± 9.8 year, BMI 23.5 ± 3.0 kg/m2) who were randomly assigned to consume either regular sugar or sugar-reduced foods and beverages for 8 weeks, separated by 4-week washout period. Body weight, energy intake (EI), energy expenditure and vascular markers were assessed at baseline and after both interventions.ResultsWe found that carbohydrate (P < 0.001), total sugars (P < 0.001) and non-milk extrinsic sugars (P < 0.001) (% EI) were lower, whereas fat (P = 0.001) and protein (P = 0.038) intakes (% EI) were higher on the sugar-reduced than the regular diet. No effects on body weight, blood pressure, arterial stiffness, fasting glycemia or lipemia were observed.ConclusionsConsumption of sugar-reduced products, as part of a blinded dietary exchange for an 8-week period, resulted in a significant reduction in sugar intake. Body weight did not change significantly, which we propose was due to energy compensation.Electronic supplementary materialThe online version of this article (doi:10.1007/s00394-015-1028-5) contains supplementary material, which is available to authorized users.

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Sucrose compared with artificial sweeteners: a clinical intervention study of effects on energy intake, appetite, and energy expenditure after 10 wk of supplementation in overweight subjects

Abstract: The changes in body weight in the 2 groups during the 10-wk intervention seem to be attributable to changes in EI rather than to changes in EE.

Cited by 40 publications

References 34 publications

Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research

Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research

Not-so-healthy sugar substitutes?

Energy compensation following consumption of sugar-reduced products: a randomized controlled trial

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