Sucrose for analgesia in newborn infants undergoing painful procedures

Stevens, Bonnie; Yamada, Janet; Lee, Grace Y.; Ohlsson, Arne

doi:10.1002/14651858.cd001069.pub4

Cited by 144 publications

(152 citation statements)

References 105 publications

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“…Once stable on ventilation there is usually no need for routine sedation [166]. Sucrose analgesia and other non-pharmacological methods may be employed to reduce procedural pain [167]. …”

Section: Managing Blood Pressure and Perfusionmentioning

confidence: 99%

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

et al. 2016

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Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe. Methods for optimal delivery room management have become more evidence based, and protocols for lung protection, including initiation of continuous positive airway pressure and titration of oxygen, should be implemented from soon after birth. Surfactant replacement therapy is a crucial part of the management of RDS, and newer protocols for surfactant administration are aimed at avoiding exposure to mechanical ventilation, and there is more evidence of differences among various surfactants in clinical use. Newer methods of maintaining babies on non-invasive respiratory support have been developed and offer potential for greater comfort and less chronic lung disease. As technology for delivering mechanical ventilation improves, the risk of causing lung injury should decrease although minimizing the time spent on mechanical ventilation using caffeine and if necessary postnatal steroids are also important considerations. Protocols for optimizing the general care of infants with RDS are also essential with good temperature control, careful fluid and nutritional management, maintenance of perfusion and judicious use of antibiotics all being important determinants of best outcome.

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“…Once stable on ventilation there is usually no need for routine sedation [166]. Sucrose analgesia and other non-pharmacological methods may be employed to reduce procedural pain [167]. …”

Section: Managing Blood Pressure and Perfusionmentioning

confidence: 99%

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

et al. 2016

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“…Sweet solution may be used in infants aged 27 or more-week gestation. The volume administered for each age group should be as follow: 27-31 weeks' gestation (0.1-0.5 mL); 32-36 weeks' gestation (0.5-1 mL) and greater than 37 weeks' gestation (1-2 mL) [5,8,9]. Dosage is usually expressed in mg.…”

Section: Sweet Solutions In the Clinical Setings And Guidelinesmentioning

confidence: 99%

“…A paradox is still observed between the frequency of conditions that cause pain among young children and the use of appropriate pain relief intervention. The most often cited causes for this paradox are the several myths surrounding the painful experience in the neonatal population, particularly the perception that the newborn is too immature to feel pain [5]. It is known that the knowledge about the presence of pain in newborns has greatly increased among health providers who are responsible for neonatal care [6], but it is not known how each professional puts such knowledge into practice [7].…”

Section: Introductionmentioning

confidence: 99%

“…Although infant's pain is not expressed as conscious memory, memories of pain may be recorded biologically and alter brain development and subsequent behavior. Some recent studies have reported that simple and benign interventions such as oral sweet solutions [5,8,9], milk [10] or sucking a paciier [11] reduce pain in neonates during procedures. Pain relieving efects of sweet solutions such as sucrose have been examined in term and preterm neonates [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Sweet Solution Analgesia

Nuseir¹,

Kassab²,

Al-Azzani³

2017

Pain Relief - From Analgesics to Alternative Therapies

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“…Even sucrose analgesia, which is extremely widespread and effective for minor procedures, has never been assessed for its long-term outcome [90], although one study reported no change in short-term outcomes [91]. On the other hand, despite the need for large trials of analgesics and/or sedatives designed to assess long-term neurodevelopment as the primary outcome, these would be considered ethically unacceptable in light of the short-term effectiveness in providing pain relief of most of these drugs.…”

Section: Pain Analgesia and Sedationmentioning

confidence: 99%

Impact of Common Treatments Given in the Perinatal Period on the Developing Brain

et al. 2014

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Background: Over the last decades, considerable progress has been made in the perinatal management of high-risk preterm neonates, changing the landscape of pathological conditions associated with neurological impairments. Major focal destructive lesions are now less common, and the predominant neuropathological lesion is diffuse white-matter damage in the most immature infants. Similarly, over the last few years, we have observed a trend towards a decrease in neurological impairment in the absence of treatments specifically aimed at neuroprotection. Objectives: We examined whether recent changes in treatment strategies in perinatal care during the perinatal period could have had an indirect beneficial impact on the occurrence of brain lesions and their consequences. Methods: Thus, we reviewed the effects of the most common treatments administered during the perinatal period to the mother or to very preterm infants on brain damage and neurocognitive follow-up. Results: Antenatal steroids and exogenous surfactant are the two main treatments capable of leading to neuroprotection in very preterm infants. Randomized controlled trials are currently investigating the effects of inhaled nitric oxide and erythropoietin, while antenatal magnesium sulphate and caffeine are also likely to provide some neuroprotection, but this needs to be further investigated. Finally, other common treatments against pain, haemodynamic failure and patent ductus arteriosus have conflicting or no effects on the developing brain. Conclusion: While specific neuroprotective drugs are still awaited, recent advances in perinatal care have been associated with an unexpected but significant decrease in the incidence of both severe brain lesions and neurological impairment.

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Sucrose for analgesia in newborn infants undergoing painful procedures

Cited by 144 publications

References 105 publications

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

European Consensus Guidelines on the Management of Respiratory Distress Syndrome - 2016 Update

Sweet Solution Analgesia

Impact of Common Treatments Given in the Perinatal Period on the Developing Brain

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