Suction-assisted lipectomy fails to improve cardiovascular metabolic markers of disease: A meta-analysis

Danilla, Stefan; Longton, Cristobal; Valenzuela, Karen; Cavada, Gabriel; Norambuena, Hernán; Tabilo, C.; Erazo, Cristián; Benítez, Susana; Sepúlveda, Sergio A.; Schulz, Rolando; Andrades, Patricio

doi:10.1016/j.bjps.2013.07.001

Cited by 26 publications

(16 citation statements)

References 33 publications

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“…However, health consequences of liposuction are still poorly understood. Moreover, the results of previous studies dealing with the problem in question are inconclusive [2,3,4,5,6]. Nevertheless, some authors showed that liposuction is safe and beneficial procedure resulting in an amelioration of insulin resistance and decrease in the markers of vascular inflammation [2,3,4,5].…”

Section: Introductionmentioning

confidence: 91%

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Dettlaff-Pokora

Śledziński

Świerczyński

2015

Cell Physiol Biochem

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Background/Aims: The aim of this study was to explain the molecular basis for elevated concentrations of circulating triglycerides (TAGs) after partial surgical removal of adipose tissue (lipectomy) in rats. Methods: The levels of mRNA and protein: a) involved in synthesis of fatty acids and TAGs; b) participating in TAG-rich lipoproteins assembly and secretion; and c) transcription factors essential for maintaining TAG homeostasis were determined by RT-PCR and Western Blot in the livers of control and lipectomized rats. Results: Partial lipectomy was associated with increase: a) in serum and liver concentration of TAGs, and b) in the liver levels of mRNA of microsomal TAG transfer protein (MTP) and apolipoprotein B-100 (ApoB-100). These changes were tightly associated with up-regulation of Hnf1a and Hnf4a gene expression in the liver. Lipectomy was also reflected by a significant increase in the expression of genes encoding: a) fatty acid synthase (FASN), b) glycerol 3-phosphate acyltransferase 1 (GPAT1), diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2), c) spot 14 protein (S14) and SREBP-1 in the liver. Conclusion: Coordinated up-regulation of Mttp, Apob, Hnf1a, Hnf4a, Fasn, Gpam and Dgat (1 and 2) gene expressions may contribute to the increase in circulating and liver concentrations of TAGs after lipectomy in an experimental rat model.

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Section: Introductionmentioning

confidence: 91%

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Dettlaff-Pokora

Śledziński

Świerczyński

2015

Cell Physiol Biochem

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“…Based on the results, authors concluded that there is no evidence to support the hypothesis that subcutaneous fat removal reduces early cardiovascular or metabolic disease, its markers or its risk factors. 27 One hypothesis is that the decrease in abdominal SAT, although substantial after liposuction, may have been insufficient enough to overcome the negative effects of the excess visceral fat on insulin sensitivity, cytokine production and lipid profile in individuals with excess of adiposity. 24 Effects of lipectomy on body fat distribution have been evaluated.…”

Section: Effects Of Adipose Tissue Removalmentioning

confidence: 99%

Different adipose tissue depots: Metabolic implications and effects of surgical removal

Marcadenti

Abreu-Silva

2015

Endocrinología y Nutrición

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“…36 A large meta-analysis concluded that there is no evidence that subcutaneous fat removal reduces early cardiovascular or metabolic disease, its markers, or its risk factors. 37 In contrast, bariatric surgery can lead to beneficial changes in peripheral blood levels of some adipokines and hormones controlling energy turnover and appetite. 38,39 Among patients with type 2 diabetes, bariatric surgery resolved or improved in most patients.…”

Section: Low-level Laser Therapy For Obesity Discussionmentioning

confidence: 99%

Low-Level Laser Therapy for Reducing the Hip, Waist, and Upper Abdomen Circumference of Individuals with Obesity

Roche

Shanks²,

Jackson³

et al. 2017

Photomedicine and Laser Surgery

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Objective: To assess the effectiveness of low-level laser therapy (LLLT) for reducing hip, thigh, and abdomen circumference of individuals with body-mass index (BMI) between 30 and 40 kg/m 2. Background: Previous studies demonstrated the effectiveness of LLLT for reducing body circumference in the hips, thighs, and abdomen of nonobese individuals with a BMI <30 kg/m 2. Methods: In this randomized, double-blind shamcontrolled study, obese, but otherwise healthy, individuals were randomized to undergo 30-min LLLT (n = 28) or sham treatments (n = 25) three times weekly for 4 weeks. Body measurements were obtained after 2 and 4 weeks of treatment and 2 weeks post-treatment (ClinicalTrials.gov Identifier: NCT01821352). Results: After 4 weeks, 20 LLLT-treated subjects (71.43%) achieved ‡7.2 cm decrease in combined measurements versus three sham-treated subjects (12%; p < 0.00005). The mean (standard deviation) decrease in combined measurement for LLLT-treated subjects was 10.52 (7.59) cm (p < 0.0001 vs. baseline) versus 1.80 (3.20) cm for sham-treated subjects. Among subjects with a combined ‡7.2 cm decrease, the mean total decrease 2 weeks post-treatment was 15.21 cm. There were no adverse events. Conclusions: Based on these results, the device was cleared by the U.S. Food and Drug Administration as a noninvasive esthetic treatment for reduction of circumference of hips, waist, and upper abdomen when applied to individuals with a BMI between 30 and 40 kg/m 2 .

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Suction-assisted lipectomy fails to improve cardiovascular metabolic markers of disease: A meta-analysis

Cited by 26 publications

References 33 publications

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia

Different adipose tissue depots: Metabolic implications and effects of surgical removal

Low-Level Laser Therapy for Reducing the Hip, Waist, and Upper Abdomen Circumference of Individuals with Obesity

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