Suction Blister Epidermal Grafts Combined with CO2 Laser Superficial Ablation as a Good Method for Treating Small-Sized Vitiligo

Ko, Wang-Cheng

doi:10.1111/j.1524-4725.2009.01098.x

Cited by 16 publications

(25 citation statements)

References 20 publications

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“…45 Additionally, BG has a repigmentation rate ranging from 80 to 90%. 14,16,17 PG is no longer recommended as it has the highest rate of adverse effects and poor cosmetic results. The suction blister procedure is an alternative, but is less effective than STSG, being time-consuming and suited to the treatment of small areas.…”

Section: Discussionmentioning

confidence: 99%

“…Grafts, harvested by cutting the roof of the blisters, are grafted onto the recipient site, which has been prepared by dermabrasion, 13 laser abrasion, 14 producing blisters induced by suction, 15 liquid nitrogen 7 or psoralen plus ultraviolet A. 16 Various types of suction apparatus are used to produce blisters depending upon the preference of the operating surgeon.…”

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confidence: 99%

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Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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SummaryBackground Vitiligo is a disfiguring disease, characterized frequently by the presence of de-pigmented macules and/or patches. Traditional therapies are essentially medical and are most preferred by dermatologists. Surgical therapies, however, are amongst the most effective interventions for vitiligo but are limited by their invasive nature, as well as the training and expertise needed to perform specific procedures. Objectives To assess the evidence for the effectiveness, safety and applicability of the various surgical methods in the treatment of vitiligo. Methods For this systematic review of vitiligo surgical therapies, our searches included: PubMed, MEDLINE and Cochrane databases. Results We reviewed research studies reporting on split thickness skin grafts (STSG), punch/mini-graft, blister roof grafting, cultured and non-cultured cellular transplantation (MKTP). While all methods vary in their repigmentation outcomes, STSG is found to have the highest repigmentation success rate. Overall, post-operative complications included milia, scarring, cobblestone appearance or hyperpigmentation of treated areas. Conclusion This review highlights the need for more randomized controlled trials in this field, underpinned by a more standardized objective approach to the assessment of repigmentation following surgical interventions.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Surgical interventions for vitiligo: an evidence-based review

Mulekar¹,

Isedeh

2013

Br J Dermatol

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“…Manual dermabrasion is simple and has the advantage of being cheap, but can be very tedious and time-consuming by itself. [1–3] We describe a simple method of combining radiofrequency ablation with manual dermabrasion for preparation of graft recipient sites in vitiligo surgery.…”

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confidence: 99%

Using the ball-shaped attachment of a radiofrequency ablation device for preparation of recipient site in vitiligo surgery

Kaliyadan

2011

Indian J Dermatol

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“…Although many medical therapeutic modalities have been improved recently, only limited successes in the treatment of vitiligo have been reported 6 . For patients who have recalcitrant and stable vitiligo, various surgical therapies can be applied, such as SBEG, split-thickness grafting, punch skin grafting, and transplantation of cultured melanocytes 7 . According to the literature, split-thickness grafting has a high success rate (>50% stable repigmentation for at least 6 months) of 78%~91%, which is comparable to that of SBEG.…”

Section: Discussionmentioning

confidence: 99%

“…Various adverse effects, including hyperpigmentation, milia formation, curling of the graft, scar formation at the recipient site, and scar or keloid formation at the donor site, were also reported 2 . Punch skin grafting is an effective method for the treatment of stable vitiligo; however, it can also induce scarring and a cobblestone appearance 7 . Transplantation of cultured melanocytes can provide a new source of melanocytes for larger vitiligous lesions; however, this method is not cost-effective 7 .…”

Section: Discussionmentioning

confidence: 99%

Fibrin Glue Fixation for Suction Blister Epidermal Grafting in Two Patients with Stable Vitiligo

et al. 2014

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Vitiligo is a chronic disorder characterized by depigmented macules which can slowly enlarge with the concurrent development of new lesions. Although autologous suction blister epidermal grafting is an established technique for the treatment of recalcitrant, stable vitiligo, the donor tissue graft is not easy to fix at the recipient site, especially in areas such as the joints, face, cutaneous folds, hands, feet, and hair-bearing areas. Therefore, various methods of donor tissue fixation have been attempted. We report two cases of vitiligo treated with suction blister epidermal grafting, with fibrin tissue adhesion. The first case is that of 16-year-old female patient presented with hypopigmented patches on the forehead and frontal scalp area. The other case is that of 32-year-old female patient presented with hypopigmented patches on the chin. We treated them with phototherapy for 1~4 years; however, the lesions were recalcitrant. Therefore, we tried treatment with a suction blister epidermal graft. Because graft fixation is difficult at the recipient sites, fibrin glue was sprayed on the grafts. Thereafter, we applied a porous silicone wound contact layer over the graft area and applied sterile gauze dressing that was left for a week. One week after the procedure, firm fixation of the donor tissue was observed in both cases. Fibrin glue seemed to improve the graft fixation, providng protection against infection and an optimal environment for wound healing. This report suggests that the application of an epidermal graft with fibrin glufixation, can provide the best result in the surgical treatment of stable vitiligo.

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Suction Blister Epidermal Grafts Combined with CO2 Laser Superficial Ablation as a Good Method for Treating Small-Sized Vitiligo

Abstract: This study suggests that SBEG combined with CO2 laser ablation is a rapid, simple, and safe method to treat vitiligo, especially for patients with small and stable vitiliginous lesions.

Cited by 16 publications

References 20 publications

Surgical interventions for vitiligo: an evidence-based review

Surgical interventions for vitiligo: an evidence-based review

Using the ball-shaped attachment of a radiofrequency ablation device for preparation of recipient site in vitiligo surgery

Fibrin Glue Fixation for Suction Blister Epidermal Grafting in Two Patients with Stable Vitiligo

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