2008
DOI: 10.1097/paf.0b013e318177eab7
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Sudden Cardiac Death and Myocardial Ischemia Indicators

Abstract: The postmortem diagnosis of acute myocardial infarction represents a current challenge for forensic pathologists, particularly when death occurs within minutes to a few hours after the ischemic insult. Among the adult population the single most important cause of sudden cardiac death (SCD) is the well-known atherosclerotic coronary artery disease, commonly asymptomatic or unrecognized. The recognition of early myocardial damage using routine hematoxylin and eosin (H&E) staining is possible only if death has oc… Show more

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Cited by 73 publications
(21 citation statements)
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“…The temporal release pattern of these cellular proteins is dependent on the extent of hypoxia, their subcellular localization, and their physicochemical characteristics, especially molecular weight. Therefore, cellular antigens, such as MB [4], cTnI [26], and H-FABP [17], can indicate early myocardial infarction based on the loss of staining in infarcted areas.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The temporal release pattern of these cellular proteins is dependent on the extent of hypoxia, their subcellular localization, and their physicochemical characteristics, especially molecular weight. Therefore, cellular antigens, such as MB [4], cTnI [26], and H-FABP [17], can indicate early myocardial infarction based on the loss of staining in infarcted areas.…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately, the postmortem diagnosis of AMI for forensic and clinical pathologists is difficult. Myocardial cell death does not occur instantaneously at the onset of ischemia, but takes at least 6 h before myocardial necrosis can be identified by standard macroscopic or microscopic postmortem examination, depending on the sensitivity of the cardiomyocytes [4]. Although many markers and various techniques have been introduced for postmortem diagnosis of AMI, currently, there is neither a marker nor a technique in routine medicolegal use that can solve this problem satisfactorily [4-6].…”
Section: Introductionmentioning
confidence: 99%
“…Human and experimental models of atherosclerosis have identified monocyte recruitment as an early event in atherogenesis. The processes of cellular adhesion, monocyte and macrophage attachment, and transmigration of immune cells across the endothelium are crucial steps in early atherogenesis and in the later stages of mature plaque rupture [1517], as well as in inflammatory airway cell trafficking at the epithelium level [1820]. …”
Section: Endothelial Dysfunction and Inflammationmentioning
confidence: 99%
“…A greater myocardial dysfunction induced by ischemia-reperfusion injury [19] represents another feature of aging process, then reinforcing the association with oxidative stress. The oxidative stress has been suggested to be also responsible for some metabolic changes.…”
Section: Aging and Oxidative Stressmentioning
confidence: 99%