Sudden Cardiac Death in Women

Haukilahti, M. Anette E.; Holmström, Lauri; Vähätalo, Juha; Kenttä, Tuomas; Tikkanen, Jani T.; Pakanen, Lasse; Kortelainen, Marja-Leena; Perkiömäki, Juha S.; Huikuri, Heikki V.; Myerburg, Robert J.; Junttila, M. Juhani

doi:10.1161/circulationaha.118.037702

Cited by 120 publications

(90 citation statements)

References 26 publications

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“…Arrhythmias have been found to increase with aging and are a major risk factor for sudden cardiac death (SCD). While ischemia is the major cause of SCD [49], women are more likely to have a nonischemic cause of SCD and female subjects with SCD are older than men [50].…”

Section: Cardiac Senescencementioning

confidence: 99%

Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging

Lin

Kerkelä

2020

IJMS

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Aging is a major risk factor for cardiovascular diseases (CVDs), the major cause of death worldwide. Cardiac myocytes, which hold the most abundant mitochondrial population, are terminally differentiated cells with diminished regenerative capacity in the adult. Cardiomyocyte mitochondrial dysfunction is a characteristic feature of the aging heart and one out of the nine features of cellular aging. Aging and cardiac pathologies are also associated with increased senescence in the heart. However, the cause and consequences of cardiac senescence during aging or in cardiac pathologies are mostly unrecognized. Further, despite recent advancement in anti-senescence therapy, the targeted cell type and the effect on cardiac structure and function have been largely overlooked. The unique cellular composition of the heart, and especially the functional properties of cardiomyocytes, need to be considered when designing therapeutics to target cardiac aging. Here we review recent findings regarding key factors regulating cell senescence, mitochondrial health as well as cardiomyocyte rejuvenation.

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Section: Cardiac Senescencementioning

confidence: 99%

Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging

Lin

Kerkelä

2020

IJMS

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“…Further definitions of these conditions have been previously described. 5 The "other" SCD victims included individuals with the following conditions: myocarditis, cardiac anomaly, and normal autopsy individuals (e.g. individuals with a channelopathy).…”

Section: Fingesturementioning

confidence: 99%

“…By contrast, nonischemic pathology, such as primary myocardial fibrosis, valvular heart disease, and arrhythmogenic right ventricular cardiomyopathy, occurs more commonly in women with SCD compared to men with SCD. [5][6][7] SCD is often the first manifestation of heart disease, particularly for women; several studies have found that women are less likely than men to have a prior history of known cardiac disease. 4,8 It has been hypothesized that SCD is a much more heterogeneous condition in women, potentially due to the different underlying diseases, leading to differences in the associated risk factors.…”

Section: Introductionmentioning

confidence: 99%

The effect of sex and underlying disease on the genetic association of QT interval and sudden cardiac death

Mitchell¹,

Ashar²,

Järvelin

et al. 2019

Preprint

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Short title: Effect of sex and underlying disease on association of QT interval and SCDWord count: 5,226 ABSTRACT Background. Sudden cardiac death (SCD) accounts for ~300,000 deaths annually in the US.Men have a higher risk of SCD and are more likely to have underlying coronary artery disease (CAD) than women. In contrast, women are more likely to have arrhythmic events in the setting of inherited or acquired QT prolongation. Moreover, there is evidence of sex differences in the underlying genetics of QT interval duration. Using sex-and CAD-stratified analyses, we assess differences in genetic association between prolonged QT interval and SCD risk.Methods. We examined 2,282 SCD subjects with autopsy-confirmed underlying disease from the Fingesture cohort and 3,561 Finnish controls. The SCD subjects were stratified by underlying disease (ischemic vs. non-ischemic) and by sex. We used logistic regression to test for association between the top QT interval associated SNP, rs12143842 (in the NOS1AP locus), and SCD risk. We also performed Mendelian randomization to test for causal association of QT interval in the various subgroups.Results. Female SCD victims with underlying non-ischemic disease had the strongest association between rs12143842 and SCD risk (OR=1.37; 95% CI, 1.07-1.75) and the strongest causal association, established using Mendelian randomization, between prolonged QT interval and SCD (OR in SCD risk per SD increase in QT, 3.60; 95% CI, 1.22-10.49). Ischemic SCD victims, irrespective of sex, did not show an association between rs12143842 and SCD risk or a causal association for QT interval. Conclusions.This study provides evidence that the causal effect of QT prolongation on SCD risk differs by sex and underlying disease.

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“…In the Fingesture study, women were considerably older at the time of sudden death, and more commonly had non-ischemic causes. Women were also more likely to have a prior normal clinical nding than men, but an increased biological marker for sudden death risk criteria for left ventricular hypertrophy with repolarization abnormalities was more commonly observed in women [13]. In addition to these non-modi able risk factors (sex, hormones, etc.…”

Section: Discussionmentioning

confidence: 99%

Sudden death in the young adult: A Tunisian autopsy-based series

Saadi

Jomâa

Hadj

et al. 2020

Preprint

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Background: We aim to study the profile, and pathological characteristics of sudden death in young in purpose of recommendations for prevention. Methods: We performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir (Tunisia). A review of all autopsies performed for 28 years was done (August 1990 to December 2018). In each case, clinical information, and circumstances of death were obtained. A complete forensic autopsy and histological, and toxicological investigations were performed. We have included all sudden death in persons aged between 18 years and 35 years.Results: We collected 137 cases of sudden death during the studied period. The mean age of the studied population was 26.47 years. Almost 72% deaths were classified as cardiac death, and was due to ischemic heart disease in 32.32%. Sudden death was attributed to a pleuropulmonary cause in 7.4%, an abdominal cause in 6%, and from a neurological origin in 4.5%. The cause of sudden death in this group was not established by 9.5%.Conclusion: In this series, sudden death in young adults occurs mainly in a smoking male, aged between 18 and 24 years old, occurring at rest, in the morning, and early in the week. It is more common, especially in summer. Sudden death is most often the first manifestation of pathologies, especially unsuspected heart diseases. The predominance of cardiovascular causes is the common denominator of almost all studies reported in the literature. Our findings suggest that prevention of sudden death among young adults under the age of 35 years should also focus on evaluation for causes not associated with structural heart disease.

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Sudden Cardiac Death in Women

Cited by 120 publications

References 26 publications

Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging

Regulatory Mechanisms of Mitochondrial Function and Cardiac Aging

The effect of sex and underlying disease on the genetic association of QT interval and sudden cardiac death

Sudden death in the young adult: A Tunisian autopsy-based series

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