2021
DOI: 10.21203/rs.3.rs-489428/v1
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Sudden Cessation of Fluoxetine Before Alcohol Drinking Reinstatement Alters Microglial Morphology and TLR4/inflammatory Neuroadaptation in the Rat Brain

Abstract: Preclinical studies on the effects of abrupt cessation of selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results in alcohol consumption escalation after resuming drinking. However, a potential neuroinflammatory component on this escalation remains unexplored despite the immunomodulatory role of serotonin. Here, we utilized a rat model of 14-daily administration of the SSRI fluoxetine (10 mg/kg/day) along alcohol self-admini… Show more

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