Sudden Deafness

Kanzaki, Jin

doi:10.1159/000027908

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…The evaluation of the hearing recovery was performed in accordance to the Research Group on Sudden Deafness of the Japanese Ministry of Health and Welfare [ 13 ] as done in a former study [ 12 ]. Recovery was defined as an average hearing gain of at least 10 dB in five frequencies (250, 500, 1,000, 2,000, and 4,000 Hz).…”

Section: Methodsmentioning

confidence: 99%

Critical Evaluation of Round Window Membrane Sealing in the Treatment of Idiopathic Sudden Unilateral Hearing Loss

Hoch

Vomhof

Teymoortash

2015

Clin Exp Otorhinolaryngol

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ObjectivesRupture of the round window membrane with consecutive development of a perilymphatic fistula (PLF) is still a matter of controversial debate in the pathogenesis of idiopathic sudden sensorineural hearing loss (SSHL). Until now no consensus exists about whether these patients benefit from performing an exploratory tympanotomy with sealing of the round window. The aim of the present study was to analyze critically the effectiveness of sealing the round window membrane in patients with SSHL.MethodsThe clinical data of 51 patients with SSHL and a mean hearing decline of at least 60 dB over 5 frequencies who were treated with tympanotomy and sealing of the round window membrane were retrospectively analyzed. The results have been compared to the current state of the literature.ResultsIntraoperatively a round window membrane rupture or fluid leak was observed in none of the patients. After performing tympanotomy the mean improvement of hearing level was 32.7 dB. Twenty of 51 examined patients (39.2%) showed a mean improvement of the hearing level of more than 30 dB and a complete remission could be detected in 12 patients (23.5%). Reviewing the literature revealed no standard guidelines for definition or treatment of SSHL as well as for evaluation of hearing loss and its recovery.ConclusionThe results of the present study and the literature should be discussed critically. It is unclear whether tympanotomy and sealing of the round window membrane may be a meaningful treatment for SSHL. Therefore this procedure should be discussed as a therapeutic option only in selected patients with sudden deafness or profound hearing loss in which PLF is strongly suspicious or conservative treatment failed.

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Section: Methodsmentioning

confidence: 99%

Critical Evaluation of Round Window Membrane Sealing in the Treatment of Idiopathic Sudden Unilateral Hearing Loss

Hoch

Vomhof

Teymoortash

2015

Clin Exp Otorhinolaryngol

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“…Notably, all have been suggested to be causes of ISHL (42Y44). Kanzaki (45) suggested the association of depletion of NKCA followed by systemic stress with the onset of ISHL. The decrease of NKCA observed in the present study might also be induced by systemic stress in ISHL patients, although GHQ scores did not have a significant correlation with biomarkers.…”

Section: Decreased Nkca and Elevated Neutrophils May Reflect The Systmentioning

confidence: 99%

Correlations of Inflammatory Biomarkers With the Onset and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

Masuda¹,

Kanzaki²,

Minami³

et al. 2012

Otology &Amp; Neurotology

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132

129

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Neutrophil counts above the reference range of a facility will be a useful indicator of poor prognosis of ISHL. Synchronism of different types of NF-κB activation pathways could be required to cause severe ISHL. An NKCA decrease, an acute neutrophil count increase, and an IL-6 increase can induce NF-κB activation in the cochlea and cause severe ISHL. Further epidemiologic surveys should be conducted to evaluate whether stressful life events increase the risk of severe ISHL onset.

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“…Pure-tone averages (at 0.25, 0.5, 1, 2, and 4 kHz, respectively) at octave or semioctave frequencies under air conduction and 0.25–4 kHz under bone conduction were measured two times per week during treatment and once every 2 weeks after the completion of treatment. The average air-conduction PTAs were obtained through the thresholds at frequencies of 0.25, 0.5, 1, 2, and 4 kHz, respectively, following the “Kanzaki criteria” ( Kanzaki, 1999 ; Table 1 ). When the hearing thresholds were undetectable, fixed values were applied for calculations as follows: 110–125–125–125–125 (0.25, 0.5, 1, 2, and 4 kHz, respectively, maximum outputs of our hospital audiometer were 105–115–115–115–115 dB, plus 5, respectively) ( Fontenot et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…When the hearing thresholds were undetectable, fixed values were applied for calculations as follows: 110–125–125–125–125 (0.25, 0.5, 1, 2, and 4 kHz, respectively, maximum outputs of our hospital audiometer were 105–115–115–115–115 dB, plus 5, respectively) ( Fontenot et al, 2019 ). Hearing gain was classified into four grades according to the PTA gain ( Kanzaki, 1999 ). Accordingly, we classified patients into the recovery (i.e., complete and marked recovery) and no recovery groups (i.e., slight and no recovery).…”

Section: Methodsmentioning

confidence: 99%

Idiopathic Sudden Sensorineural Hearing Loss in Different Ages: Prognosis of Patients With Initial Total Hearing Loss

et al. 2022

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ObjectiveThis study aimed to analyze the hearing improvement and prognosis factors of idiopathic sudden sensorineural hearing loss (ISSNHL) in different ages with initial total hearing loss.MethodsWe reviewed the medical records of 5,711 hospitalized patients with ISSNHL from 2016 to 2021 in our center. All of the patients had been treated with uniform combination drug therapy. After excluding the patients with initial partial hearing loss and those diagnosed with clear etiology, 188 patients were enrolled in this study and divided into six age groups (18–30, 31–40, 41–50, 51–60, 61–70, ≥ 71 years). In all groups, decreases in pure-tone average (PTA) 1 month posttreatment, effective rate, and clinical characteristics (vertigo, tinnitus, hospital stay, comorbidity, and inner ear magnetic resonance imaging) were analyzed.ResultsAmong the 188 enrolled patients, 86% had vertigo. Complete recovery was seen in 0.5% of patients, and marked recovery was seen in 43% of patients. The mean 1 month posttreatment PTAs were as follows: 18–30 years: 80 ± 7.5 dB; 31–40 years: 100 ± 9.0 dB; 41–50 years: 99 ± 8.3 dB; 51–60 years: 101 ± 8.6 dB; 61–70 years: 96 ± 9.6 dB; and ≥ 71 years: 88 ± 13.0 dB. Compared with the other groups, the 18–30- years group showed better recovery of hearing threshold in five frequencies (0.25, 0.5, 1, 2, and 4 kHz, respectively, at octave or semioctave frequencies under air conduction), and the recovery of hearing threshold at 0.25 and 0.5 Hz was better than the recovery at 1, 2, and 4 kHz. According to the results of the chi-square test statistical analysis, vertigo and comorbidities were associated with a poor prognosis of ISSNHL.ConclusionIn summary, the treatment outcomes of patients with ISSNHL with initial total hearing loss were poor. There was a significant age-related difference with respect to marked recovery 1 month posttreatment, and the 18–30- years group showed better recovery than the other age groups.

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Sudden Deafness

Cited by 7 publications

References 24 publications

Critical Evaluation of Round Window Membrane Sealing in the Treatment of Idiopathic Sudden Unilateral Hearing Loss

Critical Evaluation of Round Window Membrane Sealing in the Treatment of Idiopathic Sudden Unilateral Hearing Loss

Correlations of Inflammatory Biomarkers With the Onset and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss

Idiopathic Sudden Sensorineural Hearing Loss in Different Ages: Prognosis of Patients With Initial Total Hearing Loss

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