Sudden Deafness Due to Virus Infection

Lindsay, John R.

doi:10.1001/archotol.1959.00730030017003

Cited by 42 publications

(3 citation statements)

References 3 publications

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“…One of the earliest accounts of a viral infection causing sudden deafness was in 1860, when Toynbee wrote that “the peculiar poison which causes the disease generally known by the name of mumps is very often the source of complete deafness, which, however, usually occurs in one ear only” (32). In the mid-1900s, several reports proposed that ISSNHL was caused by a viral infection (33–35). This theory was further supported by histopathological studies, which suggested a possible direct viral infection from the meninges or via a hematogenous route (4,5).…”

Section: Historical Circumstance 1: Attempts To Identify the Etiology...mentioning

confidence: 99%

Roid Rage: Historical Perspective on the Emergence of Oral Steroids as a Treatment of Idiopathic Sudden Sensorineural Hearing Loss

et al. 2023

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ObjectivesTo review the historical circumstances that led to the emergence of corticosteroid therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) and to discuss how this history has influenced current perspectives on the condition.MethodsPubMed and Google scholar were used to identify articles of ISSNHL and oral corticoid steroid use. Historical articles accessed through our institutional medical library were also reviewed.ResultsThe use oral corticosteroids as a treatment for ISSNHL was seemingly influenced by three key historical circumstances that, together, provided the substrate for the treatment’s use in ISSNHL. First, ISSNHL was a frustrating condition with uncertainty regarding its etiology and few reliable treatment options. Second, the discovery of corticosteroids was awarded the Nobel Prize in 1950, which led to widespread application of this therapy. Third historical circumstance was the evolution and emergence of more rigorous methodological study designs in clinical research. In 1980, these events culminated in a double-blind study evaluating the effectiveness of oral steroids for treatment of ISSNHL. Interestingly, this study is often misrepresented as a randomized controlled trial, which ultimately contributed to adoption of a new standard for treatment in ISSNHL. Research subsequent to these historical events has challenged the notion of corticosteroids as a gold standard but has not altered the historically established paradigm of corticosteroid treatment.ConclusionsThe use of steroids as a treatment for ISSNHL evolved from our specialty’s need to address a complex condition, a novel therapeutic discovery, and a landmark study that met emerging methodological standards. Despite these strong historical foundations, ISSNHL remains a condition with an unknown etiology and the therapeutic value of corticosteroids remains unpredictable despite their gold standard label.

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Section: Historical Circumstance 1: Attempts To Identify the Etiology...mentioning

confidence: 99%

Roid Rage: Historical Perspective on the Emergence of Oral Steroids as a Treatment of Idiopathic Sudden Sensorineural Hearing Loss

et al. 2023

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“…neuropathy applies equally well to ISHL and facial palsy. 10 Activation of latent HSV-1 is known to follow stress, fever, sunburn, and immunosuppression, but it is of particular interest that in 90% of patients undergoing retrogasserian rhizotomy (transection of the sensory root fibers of the trigeminal nerve) fol' the relief of trigeminal neuralgia, there is a mucocutaneous HSV-1 eruption within the distribution of the nerve within a few days. The interruption of the path of descent by distal nerve section at the time of manipulation of the ganglion will prevent the development of HSV·I lesions.…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

The Relationship of the Herpesvirus Family to Sudden Hearing Loss: A Prospective Clinical Study and Literature Review

Wilson¹

1986

The Laryngoscope

102

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The herpesvirus family is associated with sudden hearing loss syndrome and the evidence includes clinical findings (HV-Z), temporal bone studies (CMV and HV-Z), and serologic studies. The data presented demonstrate that herpes infections, in association with sudden viral hearing loss, occur as part of a multiple viral infection in 70% of instances. This feature is unique to the herpesvirus infections when compared to other neurotropic viral agents. The study also demonstrates that the variables of viral hearing loss, such as degree of hearing loss, percentage of recovery, or the incidence of vertigo are unaffected by the presence of herpesvirus infection. Mechanisms for inner ear injury may be influenced by temporary alterations in cellular immunity secondary to simultaneous viral infections as well as the native virulence of the infecting herpesvirus.

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“…Hearing loss with mumps is usually unilateral, whereas the loss with rubella is bilateral. In both cases the temporal bone pathology includes extensive degneration of sensory cells, stria vascularis, and tectorial membrane as well as the nerve supply (46,47). Recently, the cytomegalovirus (CMV), a member of the herpes group, has been isolated from the perilymph and has been shown to cause congenital deafness.…”

Section: Ototoxic Drugs and Viral Infectionsmentioning

confidence: 99%

Review of environmental factors affecting hearing.

Mills¹,

Going²

1982

Environ Health Perspect

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The major nongenetic causes of sensorineural hearing loss are exposure to noise, aging, ototoxic drugs, viral and bacterial infections, and interactions between these factors. Regarding exposure to continuous noise, the data base from laboratory and field studies indicates that a risk of hearing loss is present when noise levels exceed 75-80 dBA. As noise level, duration and number of exposures increase so does risk. The data base for other forms of noise (intermittent, impact) is not as established. Risk of hearing loss due to impulse noise increases as the peak SPL exceeds 145-155 dB and as the duration of the impulse, the number of impulses and the number of exposures increase. High-level acoustic impulses can cause severe, permanent hearing loss.

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Sudden Deafness Due to Virus Infection

Cited by 42 publications

References 3 publications

Roid Rage: Historical Perspective on the Emergence of Oral Steroids as a Treatment of Idiopathic Sudden Sensorineural Hearing Loss

Roid Rage: Historical Perspective on the Emergence of Oral Steroids as a Treatment of Idiopathic Sudden Sensorineural Hearing Loss

The Relationship of the Herpesvirus Family to Sudden Hearing Loss: A Prospective Clinical Study and Literature Review

Review of environmental factors affecting hearing.

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