Sudden Death and Ischemic Heart Disease

Anderson, Terence W.; Riche, W. Harding le; MacKay, Jock

doi:10.1056/nejm196904102801504

Cited by 120 publications

(12 citation statements)

References 7 publications

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“…The increased risk of IHD associated with low urinary magnesium excretion complements and extends previous dietary studies showing weak inverse associations (7)(8)(9)(10)12) and autopsy reports of low intracellular magnesium in myocardial tissue after ischemic heart disease (31)(32)(33)(34). Several pathways could explain the beneficial role of magnesium on the heart.…”

Section: Discussionsupporting

confidence: 80%

Urinary and plasma magnesium and risk of ischemic heart disease

Joosten¹,

Gansevoort²,

Mukamal³

et al. 2013

The American Journal of Clinical Nutrition

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Background: Previous studies on dietary magnesium and risk of ischemic heart disease (IHD) have yielded inconsistent results, in part because of a lack of direct measures of actual magnesium uptake. Urinary excretion of magnesium, an indicator of dietary magnesium uptake, might provide more consistent results. Objective: The objective was to investigate whether urinary magnesium excretion and plasma magnesium are associated with IHD risk. Design: We examined 7664 adult participants free of known cardiovascular disease in the Prevention of Renal and Vascular EndStage Disease (PREVEND) study-a prospective population-based cohort study. Urinary magnesium excretion was measured in 2 baseline 24-h urine collections. Results: Mean 6 SD urinary magnesium excretion was 4.24 6 1.65 mmol/24 h for men and 3.54 6 1.40 mmol/24 h for women. During a median follow-up of 10.5 y (IQR: 9.9-10.8 y), 462 fatal and nonfatal IHD events occurred. After multivariable adjustment, urinary magnesium excretion had a nonlinear relation with IHD risk (P-curvature = 0.01). The lowest sex-specific quintile (men: ,2.93 mmol/24 h; women: ,2.45 mmol/24 h) had an increased risk of fatal and nonfatal IHD (multivariable HR: 1.60; 95% CI: 1.28, 2.00) compared with the upper 4 quintiles of urinary magnesium excretion. A similar increase in risk of the lowest quintile was observed for mortality related to IHD (HR: 1.70; 95% CI: 1.10, 2.61). No associations were observed between circulating magnesium and risk of IHD. Conclusions: Low urinary magnesium excretion was independently associated with a higher risk of IHD incidence. An increased dietary intake of magnesium, particularly in those with the lowest urinary magnesium, could reduce the risk of IHD.

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Section: Discussionsupporting

confidence: 80%

Urinary and plasma magnesium and risk of ischemic heart disease

Joosten¹,

Gansevoort²,

Mukamal³

et al. 2013

The American Journal of Clinical Nutrition

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“…Associations between hardness of drinking water and mortality from coronary heart disease are well established (2,9,20,23). These remarkable findings have been explained by the different content of calcium and magnesium in the drinking water (6,8,9,10,20,23).…”

mentioning

confidence: 98%

Serum and Erythrocyte Magnesium in Normal Elderly Danish People

Petersen

Schroll

Christiansen

et al. 1977

Journal of Internal Medicine

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Serum lipids, blood pressure, and magnesium levels in serum and erythrocytes have been measured in 73 men and women, aged 60. The purpose was to evaluate the relationship between the serum and erythrocyte magnesium and indicators of ischaemic heart disease. The results showed significant inverse correlations between serum magnesium levels and PB, and positive significant correlation between erythrocyte magnesium and serum cholesterol.

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“…Epidemiologie studies have shown that the consump tion of mineral rich "hard" drinking water protects against CVD, including stroke and hypertension [96,99,100,124,125]. Seelig [96] and Durlach et al [126] have pre sented evidence that water Mg (a component of water hardness) actually correlates better than total water hard ness with protection against CVD.…”

Section: Possible Influence Of Magnesium In Heart Diseasementioning

confidence: 99%

“…Other groups at risk would be those with poor dietary Mg intake, chronic alcoholics [136] and those in a state of severe malnutrition [137][138][139], those with bowel disease and malabsorption, alterations of long-chain FFA and Mg concentrations in acute myocar dial infarction [140], glucose-insulin-K infusion in acute myocardial infarction [141], and those receiving Mg-inadequate tube feeding [142,143]. In these settings, Mg depletion may cause severe tetany, coma and death [96,125].…”

Section: Possible Influence Of Magnesium In Heart Diseasementioning

confidence: 99%

Hypothesis: possible role of magnesium and calcium in the development of structure and function of the plasma membrane in mammalian cells and in human diseases.

Kummerow¹

1992

Journal of the American College of Nutrition

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Sudden Death and Ischemic Heart Disease

Cited by 120 publications

References 7 publications

Urinary and plasma magnesium and risk of ischemic heart disease

Urinary and plasma magnesium and risk of ischemic heart disease

Serum and Erythrocyte Magnesium in Normal Elderly Danish People

Hypothesis: possible role of magnesium and calcium in the development of structure and function of the plasma membrane in mammalian cells and in human diseases.

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