Sudden death due to gas gangrene caused by Clostridium septicum in goats

Gazioğlu, Abdullah; Karagülle, Burcu; Yüksel, Hayati; Açık, Mehmet Nuri; Keçeci, Hakan; Dörtbudak, Muhammet Bahaeddi̇n; Çetinkaya, Burhan

doi:10.1186/s12917-018-1747-y

Cited by 15 publications

(11 citation statements)

References 15 publications

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“…1, 2), and horses (Fig. 3), 20,53,65,70 it has also been described in other domestic mammals, including goats, 27,30 pigs (Fig. 4), 54 dogs, and cats.…”

Section: Introductionmentioning

confidence: 85%

Gas gangrene in mammals: a review

et al. 2020

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Gas gangrene is a necrotizing infection of subcutaneous tissue and muscle that affects mainly ruminants and horses, but also other domestic and wild mammals. Clostridium chauvoei, C. septicum, C. novyi type A, C. perfringens type A, and C. sordellii are the etiologic agents of this disease, acting singly or in combination. Although a presumptive diagnosis of gas gangrene can be established based on clinical history, clinical signs, and gross and microscopic changes, identification of the clostridia involved is required for confirmatory diagnosis. Gross and microscopic lesions are, however, highly suggestive of the disease. Although the disease has a worldwide distribution and can cause significant economic losses, the literature is limited mostly to case reports. Thus, we have reviewed the current knowledge of gas gangrene in mammals.

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“…1, 2), and horses (Fig. 3), 20,53,65,70 it has also been described in other domestic mammals, including goats, 27,30 pigs (Fig. 4), 54 dogs, and cats.…”

Section: Introductionmentioning

confidence: 85%

Gas gangrene in mammals: a review

et al. 2020

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“…31 In addition, gas gangrene caused by C septicum is reported in goats, considering endogenous infection due to pregnancy-induced immunosuppression due to the absence of skin lesions. 32 Similar lesions occur in blackleg disease of ruminants after oral infection with C chauvoei. In contrast to C septicum, C chauvoei spores reach the muscles through hematogenous spread from the intestine.…”

Section: Discussionmentioning

confidence: 87%

“…There is also a case report about myonecrosis due to C septicum infection in a dog with myiasis 31. In addition, gas gangrene caused by C septicum is reported in goats, considering endogenous infection due to pregnancy‐induced immunosuppression due to the absence of skin lesions 32…”

Section: Discussionmentioning

confidence: 99%

Fatal bacterial septicaemia after immobilisation of a captive brown bear (Ursus arctos)

Schlohsarczyk

Schmidt

Prenger‐Berninghoff

et al. 2020

Vet Record Case Reports

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A four‐year‐old female brown bear (Ursus arctos) was immobilised via blowpipe targeting the right hind limb to perform a chemical contraception. Few days after anaesthesia, the animal developed lameness and a reduced general condition, and died 1 week after immobilisation when alopecia and swelling of the injection area were observed for the first time. Besides a severe azotaemia, alopecia and reddening of the craniomedial skin, subcutis and skeletal muscles of the entire right hind limb showed a phlegmon, oedema and haemorrhage. Additional widespread haemorrhages were found. Histology revealed a suppurative and necrohaemorrhagic myositis of the affected limb, a suppurative iliofemoral lymphadenitis, blood resorption in the mesenteric lymph nodes and haemorrhage in the adrenal gland cortex. Microbiological investigation revealed high amounts of Escherichia coli, Streptococcus dysgalactiae and Clostridium septicum in skin, musculature, heart, lung, liver and spleen, indicating septicaemia, which led to death due to toxaemic shock.

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“…C. septicum is causes severe economic losses in livestock and poultry industries. C. septicum is responsible for braxy in sheep and cattle [69], malignant edema (gas gangrene) in ruminants [70] and Clostridial dermatitis in birds [71]. In 1969, three strains of C. septicum were isolated from malignant oedema in cattle in Iran.…”

Section: Clostridium Septicummentioning

confidence: 99%

Clostridial Vaccine for Veterinary Use in Iran: A Review

Khiav

Paradise

Langroudi

et al. 2020

MRJI

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Clostridia are Gram-positive anaerobic, spore-forming rods, found in soil, water as well as gastro-intestinal tract of human and animals worldwide. Clostridial infections are among the most prevalent diseases in Iran. Clostridium causes botulism, tetanus, food poisoning, wound infections, enterotoxaemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg and black disease. Clostridium also causes several diseases affecting the livestock and poultry industries throughout the world. Vaccination against clostridial infection is effective in immunization of domestic animals and birds. This review discusses clostridial infection and the development of vaccines against their infection in Iran. The last reported outbreaks of blackleg, black disease and enterotoxaemia occurred years ago, so these vaccines have been produced since the 1960s using traditional and conventional methods. In recent years, molecular biology methods have been developed and applied to the identification of clostridial diseases among animals. In this study, molecular cloning strategies for the major toxins of Clostridium species, for development of recombinant vaccines, were designed and evaluated. In vivo studies indicate that the recombinant vaccines will increase immunity against disease in laboratory animals. These experimental vaccines can thus be used in future pilot studies in Iran. This review article presents current knowledge regarding C. perfringens, C. novyi, C. septicum and C. chauvoei in the veterinary industry in Iran.

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Sudden death due to gas gangrene caused by Clostridium septicum in goats

Cited by 15 publications

References 15 publications

Gas gangrene in mammals: a review

Gas gangrene in mammals: a review

Fatal bacterial septicaemia after immobilisation of a captive brown bear (Ursus arctos)

Clostridial Vaccine for Veterinary Use in Iran: A Review

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