Sudden death during long distance air travel in an Hb S/C disease patient

Nadesan, Kasinathan; Nagaratnam, Menaka

doi:10.1054/jcfm.2001.0476

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…Moderate to severe PH affects about 30% of patients with sickle cell anaemia; its incidence in sickle cell disease is increasing as these patients live longer and is a major risk factor for increased mortality [7,8,12,13]. PH and pulmonary thrombosis promote the development of vasculopathy and may be worsened by splenectomy [6,13,14].…”

Section: Sickle Cell Patientsmentioning

confidence: 99%

Pulmonary endarterectomy is effective and safe in patients with haemoglobinopathies and abnormal red blood cells: the Papworth experience

Mahesh

Besser

Ravaglioli

et al. 2016

Eur J Cardiothorac Surg

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Section: Sickle Cell Patientsmentioning

confidence: 99%

Pulmonary endarterectomy is effective and safe in patients with haemoglobinopathies and abnormal red blood cells: the Papworth experience

Mahesh

Besser

Ravaglioli

et al. 2016

Eur J Cardiothorac Surg

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“…In the appropriate population sickle cell disease should be considered as a cause of sudden death [431], or a contributing factor [432,433], or when death follows exertion [434]. Hemoglobin electrophoresis is commonly used to diagnose the condition, but the diagnosis can be made from histological sections [435].…”

Section: Hematological Conditions Presenting As Sudden Deathmentioning

confidence: 99%

Sudden adult death

Langlois

2009

Forensic Sci Med Pathol

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In the investigation of sudden death in adults, channelopathies, such as long QT syndrome, have risen to the fore in the minds of forensic pathologists in recent years. Examples of these disorders are touched upon in this review as an absence of abnormal findings at postmortem examination is characteristic and the importance of considering the diagnosis lies in the heritable nature of these conditions. Typically, a diagnosis of a possible channelopathy is evoked as an explanation for a 'negative autopsy' in a case of apparent sudden natural death. However, the one potential adverse effect of this approach is that subtle causes of sudden death may be overlooked. The intention of this article is to review and discuss potential causes of sudden adult death (mostly natural) that should be considered before resorting to a diagnosis of possible channelopathy. Nonetheless, it becomes apparent that many of the potential causes of sudden death can have a genetic basis. Thus, it becomes an important consideration that there may be a genetic basis to sudden death that extends beyond the negative autopsy.

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“…Neonatal screening for sickle hemoglobin conducted in the United States of America suggests that consideration should be paid to the increased PE risk of individuals with SCT [3–6, 34]. Whilst PE has been reported with air travel in HbSC disease, we have not found a previous report of PE with HbAS following air travel, suggesting low incidence and/or underdiagnosis [35, 36]. …”

Section: Discussionmentioning

confidence: 75%

Bilateral Pulmonary Embolism after a Short-Haul Flight in a Man with Multiple Risk Factors including Sickle Cell Trait

Abdool

Ramcharan

Reyes

et al. 2017

Case Reports in Emergency Medicine

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We report a case of pulmonary embolism (PE) in an Afro-Caribbean man following a short commercial flight of less than 5,000 kilometers (Km) in economy class with a 1-month interval between journeys. He had an elevated body mass index (BMI) and sickle cell trait (SCT) with hyperhomocysteinemia. No other preexisting source of venous thrombosis was found. We posit that venous thromboembolism (VTE) and/or PE may have been a complication of SCT in an individual with other multiple risk factors. We discuss the possible interaction of these risk factors for VTE and/or PE and the implications for travelers at risk. The need for a PE risk score and guidelines for the prophylaxis of thromboembolism among travelers exists.

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Sudden death during long distance air travel in an Hb S/C disease patient

Cited by 9 publications

References 10 publications

Pulmonary endarterectomy is effective and safe in patients with haemoglobinopathies and abnormal red blood cells: the Papworth experience

Pulmonary endarterectomy is effective and safe in patients with haemoglobinopathies and abnormal red blood cells: the Papworth experience

Sudden adult death

Bilateral Pulmonary Embolism after a Short-Haul Flight in a Man with Multiple Risk Factors including Sickle Cell Trait

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