Sudden Death in Infants With Chaotic Atrial Rhythm

Yeager, Scott B.; Hougen, Thomas J.; Levy, Arthur M.

doi:10.1001/archpedi.1984.02140450071022

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…In 60 patients with CAR/CAT [Bisset et al, 1981;Liberthson and Colan, 1982;Yeager et al, 1984;Dodo et al, 1995;Fish et al, 1996;Bradley et al, 2001], 10 patients have been reported with possible or known syndromes, including three with Noonan syndrome and one each with Costello and SimpsonGolabi-Behmel syndrome [Dodo et al, 1995;Bradley et al, 2001]. In Simpson-Golabi-Behmel syndrome, cardiomyopathy is rare and includes both dilated and hypertrophic forms [Lin et al, 1999].…”

Section: Syndromes With Similar Facial and Cardiac Phenotypesmentioning

confidence: 99%

Further delineation of cardiac abnormalities in Costello syndrome

et al. 2002

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We review the cardiac abnormalities in 94 patients (27 new, 67 literature) with Costello syndrome, an increasingly recognized syndrome consisting of increased birth weight, postnatal growth retardation, and distinctive facial, skin, and musculoskeletal features (MIM 218040). A cardiac abnormality was found in 59 (63%) patients, with each of three categories occurring in approximately one-third of patients. A cardiovascular malformation (CVM) was noted in 30%, typically pulmonic stenosis (46% of those with a CVM). Cardiac hypertrophy was reported in 34%, which involved the left ventricle in 50% and was usually consistent with classic hypertrophic cardiomyopathy (HCM). A variety of rhythm disturbances were reported in 33%. Most (74%) were atrial tachycardia that was reported as supraventricular, chaotic, multifocal, or ectopic. Of 31 patients with a rhythm abnormality, 22 (68%) had an additional abnormality, i.e., CVM (4), cardiac hypertrophy (12), or both (6). Nine patients had isolated dysrhythmia, five (56%) of whom died. All of the 12 (13%) patients who died had a cardiac abnormality. One patient died of embryonal rhabdomyosarcoma, but in the remainder, a cardiac cause of death could not be disproved. All patients with Costello syndrome need a baseline cardiology evaluation with echocardiography and Holter monitoring. Additional prospective evaluations, even in patients without apparent cardiac abnormalities, would be prudent, although data are insufficient to propose a specific schedule.

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Section: Syndromes With Similar Facial and Cardiac Phenotypesmentioning

confidence: 99%

Further delineation of cardiac abnormalities in Costello syndrome

et al. 2002

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“…Though typically seen in adults with advanced chronic obstructive lung disease, it may be seen in infants and in children with or without heart disease. [69] …”

Section: Chaotic Atrial Tachycardia (Cat)mentioning

confidence: 99%

Pharmacologic Management of Arrhythmias in Patients with Congenital Heart Disease

Batra

Luna

Silka

2001

American Journal of Cardiovascular Drugs

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The management of cardiac arrhythmias has evolved rapidly over the past decade. This includes the development of more effective antiarrhythmic medications as well as catheter- and device-based therapies. Antiarrhythmic medications remain the primary treatment modality for most acute arrhythmias; however, the long term use of these medications may be accompanied by severe adverse effects. For this reason, antiarrhythmic medications are increasingly used in conjunction with other forms of therapy, such as catheter ablation or pacemaker implantation. Patients with congenital heart disease often have an increased propensity for cardiac arrhythmias due to both inherent conduction system abnormalities and impaired ventricular function. The purpose of this review is to examine the currently available antiarrhythmic drugs and assess their role in the treatment of arrhythmias in patients with congenital heart disease. It is important to emphasize that patients with congenital heart disease often have hemodynamic limitations and may be at an increased risk for developing adverse effects with antiarrhythmic agents. An awareness of the arrhythmias associated with congenital heart disease, the natural history of these arrhythmias, and the potential benefit of treatment with antiarrhythmic medications versus other forms of therapy provides a rational basis for therapy in this challenging population of patients.

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“…Im Kindesund speziell Kleinkindes-oder Säug-lingsalter scheint die chaotische Vorhoftachykardie eine deutlich bessere Prognose zu besitzen (Tabelle 2). Auch wenn Yeager et al [50] über 3 Patienten mit chaotischer Vorhoftachykardie berichteten, welche plötzlich verstorben waren, erschien hier eine direkte Kausalität allerdings nicht wahrscheinlich. Weiterhin berichteten Bisset et al über einen akuten Todesfall [10], wobei hier eine Digoxintoxizität vorgelegen haben dürfte.…”

Section: Prognoseunclassified