Sudden infant and perinatal unexplained death: are we moving forward yet?

Ottaviani, Giulia

doi:10.1016/j.carpath.2010.08.001

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…In 2002, Matturri et al ( 24 ) reported the first anatomo-pathological evidence of hypoplasia or agenesis of the arcuate nucleus in unexpected stillborns, in a similar manner than that detected in SIDS victims. Since then, additional anatomo-pathological studies confirmed similar findings in the autonomic nervous and cardiac conduction systems in both SIDS and SIUDS victims ( 2 , 9 , 11 ).…”

Section: Discussionmentioning

confidence: 52%

“…Over the years, increasing interest has been focused on the possible developmental anomalies of the cardiac conduction and autonomic nervous systems involved in the pathogenesis of SIDS and SIUDS. This interest has led to investigations of a wide number of fetuses and infants from the 25th gestational week through the first year of postnatal life ( 2 , 9 ).…”

Section: Discussionmentioning

confidence: 99%

“…Sudden infant death syndrome and SIUDS are classified as borderline or gray zone when the sudden unexpected death is concomitant to a coexistent disease, such as mild to moderate bronchus-pneumonic infection or chorionamnionitis, itself not enough to cause death, acting as a triggering phenomenon in a vulnerable infant or fetus ( 2 , 9 , 28 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

“…Congenital abnormalities, likely morphological substrates for SIDS and SIUDS, were frequently detected, mainly represented by alterations of the cardiac conduction system, such as accessory pathways and abnormal resorptive degeneration, and hypoplasia/agenesis of the vital brainstem structures ( 2 , 9 , 11 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

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Defining Sudden Infant Death and Sudden Intrauterine Unexpected Death Syndromes with Regard to Anatomo-Pathological Examination

Ottaviani

2016

Front. Pediatr.

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Crib death, or sudden infant death syndrome (SIDS), is the most frequent form of death in the first year of life, striking one baby in every 1,700–2,000. Yet, despite advances in maternal–infant care, sudden intrauterine unexplained/unexpected death syndrome (SIUDS) has a sixfold to eightfold greater incidence than that of SIDS. Frequent congenital abnormalities, likely morphological substrates for SIDS–SIUDS, were detected, mainly represented by alterations of the cardiac conduction system, such as accessory pathways and abnormal resorptive degeneration, and hypoplasia/agenesis of the vital brainstem structures. On the basis of these considerations, the new common definition of the SIDS–SIUDS complex is “The sudden death of a fetus after the 25th gestational week or infant under one year of age which is unexpected by history and remains unexplained after a thorough case investigation, including examination of the death scene, performance of a general autopsy and examination of the fetal adnexa”. Therefore, given that the general autopsy does not disclose any cause of death, a more in-depth histopathological analysis of the cardiac conduction system and autonomic nervous system by specialized pathologists is necessary.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Defining Sudden Infant Death and Sudden Intrauterine Unexpected Death Syndromes with Regard to Anatomo-Pathological Examination

Ottaviani

2016

Front. Pediatr.

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“…Overall, the SIDS–SIUDS victims did not show abnormalities of the common myocardium, while the cardiac conduction system showed pathological findings in almost all cases, such as defective or exaggerated resorptive degeneration, AV dispersion or septation, accessory pathways, mainly Mahaim fibres, cartilaginous meta/hyperplasia of the central fibrous body, dualism of the AV junction, etc, as morphological substrates for potentially deadly arrhythmias 68 103 113 114. Genetic mutations underlying cardiac arrhythmias, including the long-QT syndrome, have been detected in no more than 10% of cases of SIDS 115 116.…”

Section: Sudden Unexpected Infant and Perinatal Deathmentioning

confidence: 99%

Update on congenital heart disease and sudden infant/perinatal death: from history to future trends

Ottaviani

Buja

2017

J Clin Pathol

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During the 20th century, expert pathologists contributed an in-depth characterisation of the anatomical pathology and associated pathophysiology of congenital heart disease (CHD). Starting in the 1970s, the reported CHD birth prevalence has been increasing, owing to advances in diagnostic methods. Over the years, surgical treatments have been associated with an enormous reduction of CHD mortality. Advances also have been made in understanding the developmental biology and molecular pathogenesis of CHD. In developed countries, sudden infant death syndrome (SIDS) is the most frequent form of death during the first year of life, with a death rate of 0.42 every 1000 births. Unexpected stillbirth has a six- to eightfold greater incidence than that of SIDS and remains unexplained in 40-80% of cases even after autopsy. Specific environmental risk factors, such as maternal smoking, air and water pollution, food contamination, pesticides, etc, can interact with the genetic constitution in complex ways, which may lead to polymorphisms and/or mutations of specific genes, such as polymorphisms in the serotonin transporter gene , the regulator of the synaptic serotonin concentration. Current directions of research in this area are reviewed.

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Introduction to Sudden Infant and Perinatal Unexplained Death

Ottaviani

2014

Crib Death - Sudden Infant Death Syndrome (SIDS)

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Sudden infant and perinatal unexplained death: are we moving forward yet?

Cited by 10 publications

References 32 publications

Defining Sudden Infant Death and Sudden Intrauterine Unexpected Death Syndromes with Regard to Anatomo-Pathological Examination

Defining Sudden Infant Death and Sudden Intrauterine Unexpected Death Syndromes with Regard to Anatomo-Pathological Examination

Update on congenital heart disease and sudden infant/perinatal death: from history to future trends

Introduction to Sudden Infant and Perinatal Unexplained Death

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