Sudden Infant Death Syndrome and Apnea of Infancy

Hunt, Carl E.

doi:10.1055/s-2007-1006201

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…19 Even without multiple episodes of apnea, the group of infants with AOP have a higher incidence of SIDS. 20 Considerable attention has focused on possible central nervous system (CNS) dysfunction in infants with prolonged apnea. Hypoxia and hypoventilation have been hypothesized as a primary events leading to apnea, 21 and abnormalities of the cerebral circulation have been demonstrated during apneic events.…”

Section: Discussionmentioning

confidence: 99%

Neurodevelopmental Outcome of Infants with Apnea of Infancy

Koons¹,

Mojica²,

Jadeja³

et al. 2008

Amer J Perinatol

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The neurodevelopmental outcome of premature infants with persistent apnea of prematurity (AOP) is reported. Sixty premature infants (birthweight [BW], 1469 +/- 533 gm; gestational age [GA , 31 +/- 3 weeks) with AOP were compared to 47 control infants (BW, 1586 +/- 581 gm; GA, 31 +/- 3 weeks) matched for gestational age and degree of neonatal illness. The infants were enrolled in a multidisciplinary follow-up program, and outcome data between 12 and 24 months are reported. Assessments included the Bayley Scores of Infant Development, neurologic examinations, speech and hearing examinations. There were no significant differences in the cognitive outcome between the premature infants with AOP and the premature control group. In 50 of 60 infants the Bayley Mental Developmental Index was in the normal range (112 +/- 18) as was 39 of 47 of the control group (112 +/- 13). Delays in motor development were seen in both premature groups, although a greater percentage of premature infants with persistent apnea had mild motor delays than did control infants. There was a comparable incidence of cerebral palsy (8% vs 11%), speech delays (20% vs 23%), retinopathy (8% vs 13%), and esotropia (7% vs 4%) between the infants with AOP and the premature control infants. The presence of persistent neonatal apnea without additional adverse perinatal events did not appear to be associated with a higher incidence of significant developmental problems.

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Section: Discussionmentioning

confidence: 99%

Neurodevelopmental Outcome of Infants with Apnea of Infancy

Koons¹,

Mojica²,

Jadeja³

et al. 2008

Amer J Perinatol

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show abstract

“…The studies using the CHIME memory monitor and extensive database 1,[5][6][7][8] are unique in comparison to other studies [9][10][11][12][13] because the CHIME monitor provides data for substantially longer periods of time preceding events, and for periods when there are no events. Across a broader range of postmenstrual and postnatal ages, the CHIME data base includes not only a substantial number of events exceeding the threshold for a CE but also a subset of more severe or extreme events (EE) of potentially greater clinical significance (Table 1A).…”

Section: Discussionmentioning

confidence: 99%

“…5 Although it is not possible to compare directly these results to other studies, it is nevertheless important to consider the extent to which our results may be consistent with prior studies or may enhance our knowledge regarding apnea and bradycardia-related events in at-risk-for-SIDS groups, As recently reviewed, numerous studies have been conducted in infants born premature, SIDS-sibs, and ALTE infants, and have included comparisons with healthy full term infants. [9][10][11][12][13][14][15] These earlier studies indicate evidence of impaired autonomic regulation of cardiorespiratory systems, including increased frequency of mixed and central apneas and respiratory pauses, periodic breathing, differences in resting respiratory or heart rate, and altered heart rate variability or decreases in sustained heart rate changes to respiratory events. Although our threshold criteria for defining a bradycardia event were more stringent than what is typically used to trigger a monitor alarm for bradycardia, heart rate decelerations or more brief bradycardias associated with shorter periods of apnea were not ignored since they were included in the analyses of each recorded event.…”

Section: Discussionmentioning

confidence: 99%

Precursors of cardiorespiratory events in infants detected by home memory monitor

Hunt

Corwin

Lister³

et al. 2007

Pediatric Pulmonology

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Summary. In 1,079 infants monitored for >700,000 hr at home for apnea or bradycardia, we found an association between infants having multiple events exceeding conventional or a priori defined more extreme thresholds and less favorable developmental outcome at 1 year of age than infants with few or no events. If it is necessary to prevent such events to minimize risk for developmental morbidity, there is reason to determine whether there are disturbances in advance of the apnea or bradycardia that herald their onset. In the 85 infants with at least 1 extreme event and 1 conventional event, we hypothesized that apnea and bradycardia do not occur de novo but rather are preceded by cardiorespiratory and hemoglobin O 2 saturation changes. We compared recorded time intervals preceding these events, and we analyzed three preceding time intervals for each conventional and extreme event, and each non-event recording: Time-2 hr: up to 2 hr before; Time-1 hr: up to 1 hr before; and Time-75 sec: the 75 sec immediately preceding each event. O 2 saturation progressively decreased preceding both conventional and extreme events, and progressive increases occurred in heart and breathing rate variability. Duration of respiratory pauses and of periodic breathing progressively increased preceding conventional events, respiratory rate variability increased immediately preceding conventional events and at 1 hr preceding extreme events, and O 2 saturation decreased immediately preceding both conventional and extreme events. Thus, conventional and extreme events do not occur de novo but rather are preceded by autonomic instability of the cardiorespiratory system. Pediatr Pulmonol. 2008; 43:87-98. ß 2007 Wiley-Liss, Inc.

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Sudden infant death syndrome: The neurobehavioral perspective

Hunt

1991

Journal of Applied Developmental Psychology

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Sudden Infant Death Syndrome and Apnea of Infancy

Cited by 5 publications

References 43 publications

Neurodevelopmental Outcome of Infants with Apnea of Infancy

Neurodevelopmental Outcome of Infants with Apnea of Infancy

Precursors of cardiorespiratory events in infants detected by home memory monitor

Sudden infant death syndrome: The neurobehavioral perspective

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