Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets

Ivanov, Dmitry O.; Mironova, Ekaterina; Polyakova, V. O.; Evsyukova, I. I.; Osetrov, Michail; Kvetnoy, I. M.; Nasyrov, Ruslan A.

doi:10.1371/journal.pone.0256197

Cited by 7 publications

(5 citation statements)

References 82 publications

(90 reference statements)

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“…The presented results of this study have significant value regarding the development of endothelium investigation methods, the production and usage of new endotheliumprotective therapy in COVID-19 medical practice, and the prevention of other diseases, even those of non-infectious origin [44].…”

Section: Discussionmentioning

confidence: 87%

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COVID-19 in Children: Molecular Profile and Pathological Features

Nasyrov,

Ivanov,

Krasnogorskaya

et al. 2023

IJMS

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Although the World Health Organization has declared the end of the COVID-19 pandemic, doctors continue to register new cases of the disease among both adults and children. Unfortunately, the course of COVID-19 in children can have a severe form, with death being a potential outcome. The absence of published works discussing the pathological morphology of COVID-19 in children prevents the objective analysis of the disease’s pathogenesis, including among the adult population. In this vein, the objective of our study is to identify the morphological features of the lungs’ involvement and evaluate virus–host interactions in the case of COVID-19 in patients at a pediatric medical practice. We present the results of the study of the lungs of three children who died due to COVID-19, highlighting the predominant involvement of their respiratory organs at different stages of the disease (5, 21, and 50 days). This article presents data obtained from histopathological and immunohistochemical investigations, taking into account the results of clinical and laboratory indicators and intravital and postmortem SARS-CoV-2 PCR investigations. The common finding of all of the examined COVID-19 cases is the involvement of the endothelium in microcirculation vessels, which are considered to be a primary target of various pathogenic influencing factors. We also discuss both the significance of apoptosis as a result of virus–host interactions and the most likely cause of endothelium cell destruction. The results of this study could be useful for the development of endothelium-protective therapy to prevent the progression of disseminated intravascular coagulation syndrome.

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Section: Discussionmentioning

confidence: 87%

“…The Mouse/Rabbit UnoVue HRP/DAB Detection System (manufactured by Diagnostic BioSystems, Pleasanton, CA, USA) was used for the IHC procedure. IHC staining was carried out according to both the recommendations of the manufacturers and our own experience [43][44][45]. CD95 is one of the most informative apoptosis markers.…”

Section: Methodsmentioning

confidence: 99%

COVID-19 in Children: Molecular Profile and Pathological Features

Nasyrov,

Ivanov,

Krasnogorskaya

et al. 2023

IJMS

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“…By the time of birth it provides optimal functioning of the cardiovascular system by synchronizing the circadian oscillators in the heart, vessels, and their coordinating brain centers. This synchronizing effect of melatonin depends on the density of its receptors in various structures that control the volume and vascular resistance [103].…”

Section: Melatonin In Other Visceral Organsmentioning

confidence: 99%

“…Numerous studies in the fields of neurology, endocrinology, cardiology, oncology, reproductive and perinatal medicine have demonstrated the key role of MT in the protection of tissues against damage through beneficial effects on oxidative phosphorylation of mitochondria, antioxidant, and free radical activity, through immunomodulatory and antiapoptotic effects, as well as maintenance of chronobiological homeostasis [103,[163][164][165][166][167]. MT treatment of brain ischemia increases survivability and reduces neurodegeneration and postischemic neuron loss, providing evidence for MTs' potential as a neuron protector in both adults and children [152,168].…”

Section: Melatonin As a Neuroimmunoendocrine Marker And Molecular Tar...mentioning

confidence: 99%

Melatonin as the Cornerstone of Neuroimmunoendocrinology

Kvetnoy

Ivanov

Mironova

et al. 2022

IJMS

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Much attention has been recently drawn to studying melatonin – a hormone whose synthesis was first found in the epiphysis (pineal gland). This interest can be due to discovering the role of melatonin in numerous physiological processes. It was the discovery of melatonin synthesis in endocrine organs (pineal gland), neural structures (Purkinje cells in the cerebellum, retinal photoreceptors), and immunocompetent cells (T lymphocytes, NK cells, mast cells) that triggered the evolution of new approaches to the unifield signal regulation of homeostasis, which, at the turn of the 21st century, lead to the creation of a new integral biomedical discipline—neuroimmunoendocrinology. While numerous hormones have been verified over the last decade outside the “classical” locations of their formation, melatonin occupies an exclusive position with regard to the diversity of locations where it is synthesized and secreted. This review provides an overview and discussion of the major data regarding the role of melatonin in various physiological and pathological processes, which affords grounds for considering melatonin as the “cornerstone” on which neuroimmunoendocrinology has been built as an integral concept of homeostasis regulation.

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“…Following the publication of this article [ 1 ], concerns were raised regarding Figs 1, 5, and 6 Specifically,…”

mentioning

confidence: 99%